Preparation method of ceftiofur microspheres

Abstract

The invention discloses a preparation method of ceftiofur microspheres, and relates to the field of veterinary drugs, and the preparation method comprises the following steps: 1, dissolving a polylactic acid-polyethylene glycol segmented copolymer as a carrier material in an organic solvent; 2, adding ceftiofur, and stirring and mixing to prepare a dispersion phase; 3, adding the dispersion phaseinto water, adding an emulsifier, and magnetically stirring and emulsifying to obtain an emulsion; 4, rapidly stirring the emulsion for a period of time T1, supplementing water, and continuously stirring for a period of time T2 until the organic solvent is completely volatilized; and 5, centrifuging, washing, collecting and drying in vacuum to obtain the ceftiofur microsphere. According to the ceftiofur sustained-release microsphere disclosed by the invention, a drug is more uniformly dispersed in a carrier material, the drug loading capacity is high, a dispersion system of drug particles is reduced by virtue of a nanoscale microsphere technology, and the ceftiofur sustained-release microsphere has better needle permeability, so that the drug has a stronger sustained-release effect and a longer sustained drug effect.

Description

technical field

[0001] The invention relates to the field of veterinary medicine, in particular to a preparation method of ceftiofur microspheres. Background technique

[0002] Ceftiofur is the third-generation cephalosporin for animals. It is widely used all over the world because of its strong antibacterial activity, broad antibacterial spectrum, excellent pharmacokinetic characteristics, small toxic and side effects, and low residue.

[0003] At present, the ceftiofur-related preparations that have been marketed in China mainly include ceftiofur injection, ceftiofur sodium powder injection, and ceftiofur hydrochloride injection. Since ceftiofur is not well absorbed orally, it is mainly used by injection. To reach the effective therapeutic concentration, multiple injections are required, usually once a day for 3 to 5 consecutive days, which is very inconvenient in the clinical application process. In order to reduce the animal stress response caused by frequent injection ...