3D printed mechanical bionic auricle cartilage tissue engineering scaffold and manufacturing method thereof

A 3D printing and cartilage tissue technology, applied in tissue regeneration, medical science, additive processing, etc., to achieve the effect of saving printing materials, excellent printability, and reducing support structures

Active Publication Date: 2021-02-12
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although personalized scaffolds with fine structures can be obtained by 3D printing technology and used for the construction of tissue-engineered auricular cartilage, a problem that cannot be ignored is that the formation of cartilage tissue is affected by the mechanical properties of the scaffold. The ideal auricular cartilage tissue The engineered scaffold should have mechanical properties similar to those of the natural ear, give seed cells suitable biomechanical signals, and effectively maintain the shape and structural integrity of the engineered auricle tissue

Method used

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  • 3D printed mechanical bionic auricle cartilage tissue engineering scaffold and manufacturing method thereof
  • 3D printed mechanical bionic auricle cartilage tissue engineering scaffold and manufacturing method thereof
  • 3D printed mechanical bionic auricle cartilage tissue engineering scaffold and manufacturing method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] 1. Use 123D Design 2.2.14 to design a cube model of 8mm×8mm×3mm, select the PLCL-PCL blend with a ratio of 90:10 as the raw material (CN201910139657.9), and print it by melt extrusion deposition (FDM) Method, using a desktop 3D printer to print at 170°C, printing speed 2mm / s, and 70% filling conditions, to obtain a cube model with a porous and borderless structure, measure and print to obtain the actual three-dimensional size value of the model, and according to the size data of the original model, Calculate the shrinkage rates on the X, Y and Z axes in 3D printing respectively, and the results are: length (X axis), 6.75%±0.51%; width (Y axis), 10.82%±0.43%; height (Z axis ), 2.35%±0.73%.

[0035] 2. In Materialize Magics24.0, convert the acquired auricle cartilage scan file into a digital model file and adjust its contact angle with the horizontal plane to maximize the contact area with the horizontal plane; according to the X, Y and Z calculated in step 1) The result...

Embodiment 2

[0037] 1. In Magics 24.0, the adjusted auricle cartilage digital model in step 2) of Example 1 is divided into digital model areas of the tragus, antitragus, helix, antihelix, concha and scaphoid according to the anatomical structure, and The maximum area of ​​the cylindrical area with a flat structure can be selected as a reference, and the area of ​​the digital model of the tragus, antitragus, helix, antihelix, concha and scaphoid is selected separately to meet the mechanical performance test requirements of the bracket . According to the shrinkage results of the 90:10 PLCL-PCL blend 3D printed 70% filling rate cube bracket on the X, Y and Z axes, the digital model of the selected area is scaled and adjusted, and the 3D is 3D according to the above process and conditions Print borderless porous scaffolds.

[0038] 2. The model bracket of the selected area of ​​the mechanical test obtained by 3D printing in step 1) is tested on the mechanical performance of compression defor...

Embodiment 3

[0040] 1. Use 123D Design 2.2.14 to design a cube model with a porous frameless structure of 8mm×8mm×3mm, select the PLCL-PCL blend with a ratio of 80:20 as the raw material, and print it by melt extrusion deposition (FDM) , using a desktop 3D printer to print the model with a filling rate of 70% at 170°C and a printing speed of 2mm / s, measure and print the actual 3D size of the model, and calculate the X , Y and Z three-axis shrinkage, the results are: length (X axis), 6.75% ± 0.51%; width (Y axis), 10.82% ± 0.43%; height (Z axis), 2.35% ± 0.73% .

[0041] 2. In Magics24.0, convert the acquired auricular cartilage scan file into a digital model file and adjust its contact angle with the horizontal plane to maximize the contact area with the horizontal plane; according to the X, Y and Z three dimensions calculated in step 1), The shrinkage rate results on the axis, after zooming and adjusting the digital model of the auricle cartilage, output it as a 3D printing STL format fi...

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Abstract

The invention relates to a 3D printed mechanical bionic auricle cartilage tissue engineering scaffold and a manufacturing method thereof. A personalized auricle cartilage scaffold is printed accordingto an individual auricle cartilage structure model of a patient through a 3D printing technology, and the tissue engineering scaffold is formed by printing a biodegradable composite material (PLCL-PCL) of Poly-L-lactide-caprolactone (PLCL) and polycaprolactone (PCL) capable of being subjected to 3D printing disclosed in CN201910139657.9. The frameless, porous and pore-through auricle cartilage tissue engineering scaffold is good in biocompatibility, degradability and thermal stability, has a fine and complex three-dimensional structure of auricle cartilage, has the mechanical property characteristic similar to that of a corresponding anatomical region of natural human auricle cartilage tissue, is adaptive to the mechanical property of the natural auricle cartilage, and can be applied to construction of personalized tissue engineering auricle cartilage.

Description

technical field [0001] The invention relates to a 3D printed mechanical bionic auricle cartilage tissue engineering support and a manufacturing method thereof, belonging to the technical field of tissue engineering. Background technique [0002] There is currently no satisfactory clinical treatment for ear cartilage defects caused by congenital deformities, trauma, infection, tumors, and surgery. Tissue engineering technology provides a very promising approach for the repair and reconstruction of auricular cartilage. Generally, tissue engineering technology is to plant seed cells on tissue engineering scaffolds to construct a three-dimensional complex of cells and biomaterials. Among them, tissue engineering scaffold is one of the three elements of tissue engineering construction. An ideal tissue engineering scaffold should have good biocompatibility and biodegradability, a three-dimensional porous structure with appropriate volume and shape, high porosity, and interpenetr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/56A61L27/26B33Y10/00B33Y70/00B33Y80/00
CPCA61L27/50A61L27/56A61L27/26B33Y10/00B33Y70/00B33Y80/00A61L2430/14C08L67/04
Inventor 李学敏王艺蒙王自强张逸芸段瑞平杜博刘玲蓉
Owner INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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