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Calcium and vitamin K2 tablet and preparation method thereof

A vitamin and tablet technology, applied in the directions of pill delivery, pharmaceutical formulations, aluminum/calcium/magnesium active ingredients, etc., can solve the problems of high requirements for storage methods, insufficient stability of vitamin K2, degradation of vitamin K2, etc. Bioavailability, stable production operation characteristics, easy absorption effect

Pending Publication Date: 2021-02-19
广州富诺营养科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the calcium tablets containing vitamin K2 provided by this invention can supplement a certain amount of calcium and vitamin K2, the vitamin K2 in this invention is not stable enough, easily sensitive to light and heat, and has high requirements for storage methods
[0006] As vitamin K2 has been paid more and more attention and widely used, its instability problem has also become more prominent. Currently, vitamin K2 on the market is a direct product after extraction without embedding and other technologies. Sensitive to light and heat, resulting in rapid degradation of the content, which poses a great challenge to the stability of the product
At the same time, because vitamin K2 is easily degraded by the influence of some metal ions, it also has certain limitations in formula matching.

Method used

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  • Calcium and vitamin K2 tablet and preparation method thereof
  • Calcium and vitamin K2 tablet and preparation method thereof
  • Calcium and vitamin K2 tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1, a kind of calcium adds vitamin K2 tablet

[0034] The calcium plus vitamin K2 tablet consists of the following ingredients and parts by weight: 100 parts of calcium source, 2 parts of embedded vitamin K2 powder, 20 parts of sorbitol, 30 parts of maltodextrin, 0.4 part of silicon dioxide, 1 part of magnesium stearate, 2 parts of aloe vera juice, 150 parts of water.

[0035] The calcium source in the calcium plus vitamin K2 tablet is calcium carbonate.

[0036] The embedded vitamin K2 powder in the calcium plus vitamin K2 tablet consists of the following ingredients and parts by weight: 10 parts of microcapsule wall material, 5 parts of antioxidant, 20 parts of carrier, 70 parts of vitamin K2 powder, 100 parts of water share.

[0037] The microcapsule wall material in the embedded vitamin K2 powder in the calcium plus vitamin K2 tablet is composed of methylcellulose and corn gum in a weight ratio of 1:2, and the antioxidant is composed of vitamin E, tea po...

Embodiment 2

[0046]Embodiment 2, a kind of calcium adds vitamin K2 tablet

[0047] The calcium plus vitamin K2 tablet consists of the following ingredients and parts by weight: 110 parts of calcium source, 4 parts of embedded vitamin K2 powder, 30 parts of sorbitol, 40 parts of maltodextrin, 0.8 parts of silicon dioxide, 1.2 parts of magnesium stearate, 2.5 parts of aloe vera juice, 160 parts of water.

[0048] The calcium source in the calcium plus vitamin K2 tablet is calcium citrate.

[0049] The embedded vitamin K2 powder in the calcium plus vitamin K2 tablet consists of the following ingredients and parts by weight: 12 parts of microcapsule wall material, 6 parts of antioxidant, 25 parts of carrier, 80 parts of vitamin K2 powder, 110 parts of water share.

[0050] The microcapsule wall material in the embedded vitamin K2 powder in the calcium plus vitamin K2 tablet is composed of methylcellulose and corn gum in a weight ratio of 3:4, and the antioxidant is composed of vitamin E, tea...

Embodiment 3

[0059] Embodiment 3, a kind of calcium adds vitamin K2 tablet

[0060] The calcium plus vitamin K2 tablet consists of the following ingredients and parts by weight: 116 parts of calcium source, 14 parts of embedded vitamin K2 powder, 26 parts of sorbitol, 41 parts of maltodextrin, 1.8 parts of silicon dioxide, 1.2 parts of magnesium stearate, 2.8 parts of aloe vera juice, 168 parts of water.

[0061] The calcium source in the calcium plus vitamin K2 tablet is calcium carbonate.

[0062] The embedded vitamin K2 powder in the calcium plus vitamin K2 tablet consists of the following components and parts by weight: 15 parts of microcapsule wall material, 8 parts of antioxidant, 23 parts of carrier, 87 parts of vitamin K2 powder, 125 parts of water share.

[0063] The microcapsule wall material in the embedded vitamin K2 powder in the calcium plus vitamin K2 tablet is composed of methyl cellulose and corn gum in a weight ratio of 2:3, and the antioxidant is composed of vitamin E,...

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Abstract

The invention belongs to the technical field of health care product production, and particularly relates to a calcium and vitamin K2 tablet and a preparation method thereof. The calcium and vitamin K2tablet is mainly prepared from a calcium source, embedded vitamin K2 powder, sorbitol, maltodextrin, silicon dioxide, magnesium stearate, aloe juice and water, wherein the embedded vitamin K2 powderis mainly prepared from of a microcapsule wall material, an antioxidant, a carrier, vitamin K2 powder and water. Calcium carbonate and embedded vitamin K2 are matched, so that instability of vitamin K2 is avoided from the aspect of raw materials; the calcium carbonate serves as a main calcium source, and compared with calcium citrate and the like, the calcium carbonate is higher in calcium content; and the pH value does not need to be adjusted during formula design, and formula design and production operation are facilitated. In addition, the product is prepared through the procedures of mixing, packaging and the like, efficient and stable production operation can be achieved, and production conversion can be achieved easily.

Description

technical field [0001] The invention belongs to the technical field of health product production, and in particular relates to a calcium plus vitamin K2 tablet and a preparation method thereof. Background technique [0002] Calcium is the most abundant mineral in the human body. It participates in the entire life process of the human body and is the foundation of human life. From bone formation, muscle contraction, heart beating, nerve and brain thinking activities, to the growth and development of the human body, eliminating fatigue, strengthening the brain, improving intelligence, and delaying aging, it can be said that all activities of life are inseparable from calcium. Calcium participates in the neuromuscular stress process in the human body; it is necessary to maintain the acid-base balance in the body, maintain and regulate many biochemical processes in the body, it can promote the activities of various enzymes in the body, and is a variety of enzyme activators, such...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/50A61K47/26A61K47/36A61K47/04A61K47/12A61K47/46A61K47/38A61K33/10A61P19/08A61K31/122
CPCA61K9/2018A61K9/2059A61K9/2009A61K9/2013A61K9/2068A61K9/5042A61K9/5036A61K31/122A61K33/10A61P19/08
Inventor 程彦邓颖妍张晓洁
Owner 广州富诺营养科技有限公司
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