Magnetic core-shell microcapsule generation method based on surface acoustic wave microfluidic device

Abstract

The invention discloses a magnetic core-shell microcapsule generation method based on a surface acoustic wave microfluidic device. The surface acoustic wave microfluidic device comprises a piezoelectric substrate, an arc-shaped interdigital transducer is arranged on the piezoelectric substrate, and a PDMS micro-channel system is attached to the upper portion of the piezoelectric substrate; and thePDMS micro-channel system comprises a first-stage T-shaped channel and a second-stage cross-shaped channel. The method comprises the following steps: adjusting the flow rates of an inner phase, an intermediate phase and an outer phase, shearing the inner phase into micro-droplets at a communicating port of a T-shaped flow channel by the intermediate phase, and shearing the intermediate phase containing the inner phase droplets into micro-droplets with a core-shell structure at a communicating port of a cross-shaped flow channel by the outer phase. The arc-shaped interdigital transducer enables sound radiation force generated by surface acoustic waves to act on the interface of the inner phase and the intermediate phase, so that the interface is deformed, the size and the shell thickness of liquid drops of the inner phase are regulated and controlled, and finally, the magnetic core-shell microcapsules are formed after irradiation of an ultraviolet lamp. According to the invention, thegeneration size and the shell thickness of the core-shell magnetic microcapsule can be flexibly regulated and controlled in real time.

Description

technical field [0001] The invention relates to the field of microfluidic technology, in particular to a method for generating magnetic core-shell microcapsules based on a surface acoustic wave microfluidic device. Background technique [0002] Core-shell microcapsules are structured composite particles composed of at least two different materials, and the core step of its formation lies in the generation of core-shell droplets. The traditional method of generating core-shell droplets mostly uses multi-emulsion droplets as templates, and core-shell microcapsules are prepared by methods such as interfacial polymerization, which can only control the size and composition of the microcapsules to a limited extent. Through microfluidics, not only the size of droplets can be precisely controlled by controlling the flow rate, but also a high degree of flexibility in material selection and hierarchical order selection can be achieved, providing versatility in membrane properties and ...

AI Technical Summary

Problems solved by technology

However, no matter whether an air pump or a syringe pump is used as the input liquid phase device, a certain length of pipeline is required to connect with the microfluidic chip, resulting in a time difference in the generation of reaction changes when changing the pressure or flow rate, and real real-time regulation cannot be realized.

Moreover, during the formation of core-shell droplets, often adjusting the flow rate of one inlet will affect the flow rate of other channels at the same time, affecting the precise control of the core-shell structure.

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