Preparation method of L-erythro biopterin compound

A biopterin and compound technology, which is applied in drug combination, organic chemistry, metabolic diseases, etc., can solve the problems of complex operation, difficult purification, expensive raw materials, etc., and achieve the effects of reducing environmental pollution, shortening reaction routes, and reducing production costs
CN112390800AActive Publication Date: 2021-02-23SHANGHAI FOREFRONT PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI FOREFRONT PHARMA CO LTD
Publication Date
2021-02-23

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Abstract

The invention relates to a preparation method of an L-erythro biopterin compound, wherein the L-erythro biopterin compound has a structure as shown in a formula (I), and the L-erythro biopterin compound as shown in the formula (I) is mainly prepared from a compound with a structure as shown in a formula (II) or a formula (III) through a dihydroxylation reaction. The preparation method of the L-erythro biopterin compound is high in production efficiency, low in cost, green, environmentally friendly and suitable for industrial production.
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Description

technical field

[0001] The invention relates to the technical field of medicine preparation, in particular to a preparation method of L-erythrotype biopterin compounds. Background technique

[0002] Formula (I) indicates that L-erythro-biopterin compounds are important intermediates of most drugs at present, especially sapropterin drugs. For example: (R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-4( 3H)-pteridinone (BH4), which is an essential coenzyme in hydroxylation reaction and oxygenase in organisms, is the most important coenzyme of nitric oxide synthase (NOS), and its hydrochloride (i.e. dihydrochloride sapyl Pterin, whose structural formula is formula (I-3)) has been approved by many countries for the treatment of phenylketonuria.

[0003]

[0004] And the main method of synthesizing sapropterin dihydrochloride at present is to obtain by hydrogenation reduction of the compound shown in formula (I-1).

[0005]

[0006] Therefore, how to safely...

Claims

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