Biological polysaccharide for preventing and treating oral diseases and application thereof

A technology for oral diseases and diseases, applied in the field of biological polysaccharides, can solve problems such as side effects and ineffective treatment effects, and achieve good water-soluble effects

Pending Publication Date: 2021-02-26
ZHEJIANG GLLION BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The above-mentioned drugs for the treatment of oral diseases either have ineffective therapeutic effects or have certain side effects. Therefore, it is of great significance to develop new drugs for the prevention and treatment of oral diseases.

Method used

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  • Biological polysaccharide for preventing and treating oral diseases and application thereof
  • Biological polysaccharide for preventing and treating oral diseases and application thereof
  • Biological polysaccharide for preventing and treating oral diseases and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0206] Obtaining and Determination of β-glucan

[0207] This example only takes the β-glucan obtained by fermentation of Schizophyllum as an example, but is not limited thereto.

[0208] 1. Obtaining the fermentation broth of Schizophyllum strains

[0209] The fermented liquid in the following examples is passed through fermentation Schizophyllum strain (Schizophyllum commune Fr-1003, catalogue: 38548 TM , purchased from the American Type Culture Collection [ATCC]), the details are as follows:

[0210] 1. Activation of Schizophyllum strains: 200g / L of potatoes, 30g / L of glucose, 10g / L of sodium chloride, and 20g / L of agar are made into a plate medium, and the strains of Schizophyllum are inoculated on the plate medium , cultured in a constant temperature incubator at 25°C for 7 days to obtain plate mycelium;

[0211] 2. Seed activation: put potato starch 100g / L, glucose 40g / L, yeast extract 2g / L, yeast extract powder 2g / L, and water into a shaker flask, and the liquid vol...

Embodiment 2

[0263] Composition of embodiment 2 toothpaste and preparation method thereof

[0264] (1) Toothpaste formula (%)

[0265] Table 4 Toothpaste formulations for periodontal disease

[0266]

[0267]

[0268] (2) Preparation method

[0269] ① Disperse xanthan gum, sodium carboxymethylcellulose and essence in glycerin according to the formula table;

[0270] ②Add 20ml of 1% Schizophyllum β-glucan solution and 25g of sorbitol, and stir well to dissolve;

[0271] ③ Add 20g of hydrated silica and homogenize with a homogenizer to fully disperse the hydrated silica in the system;

[0272] ④The components of phase B are dissolved in water first, then added to the above system, and fully stirred;

[0273] Use a vacuum pump to defoam and subpackage.

Embodiment 3

[0274] Example 3 Toothpaste containing Schizophyllum β-glucan improves periodontal disease

[0275] (1) Call 20 volunteers to test the improvement of Schizophyllum β-glucan on periodontal disease. Twenty volunteers used the toothpaste containing Schizophyllum β-glucan prepared in Example 2, and compared the improvement of periodontal inflammation and oral hygiene before and after use.

[0276] (2) Experimental method:

[0277] 1. Medical history collection

[0278] Comprehensively inquiring about the periodontal disease history of patients, conducting careful clinical examination and looking for risk factors, and comprehensively analyzing the obtained data are the basis of periodontal disease diagnosis. It should be noted that periodontal disease is closely related to the whole body. During the examination and diagnosis, the patient's general condition and changes in other parts of the oral cavity should be included.

[0279] (1) Systematic medical history

[0280] Systemi...

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Abstract

The invention provides a biological polysaccharide capable of preventing and treating oral diseases and application thereof. Specifically, the invention provides application of beta-glucan to preparation of a preparation or a composition, and the preparation or the composition is used for preventing and / or treating the oral diseases. The beta-glucan has the effects of obviously relieving and improving the oral diseases and controlling the occurrence and development of the oral diseases, and can be used for preparing oral cleaning products.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a biological polysaccharide capable of preventing and treating oral diseases and its application. Background technique [0002] The oral cavity is the starting part of the digestive tract and one of the important organs of the human body. In addition to its own functions, it is also a "window" of the health of the whole body. Some systemic diseases can manifest in the oral cavity, or even manifest in the oral cavity first. Various diseases can occur in periodontal tissue and oral mucosa system, such as acute and chronic non-specific infectious inflammation, some special infections (such as syphilis, tuberculosis, AIDS, etc.), trauma, deformity, tumor, and some systemic diseases (including certain congenital diseases) can also occur in the oral cavity. [0003] Oral mucosal diseases refer to a variety of infectious and non-infectious diseases that occur in the oral mucosa and oral s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/716A61K8/73A61P1/02A61Q11/00
CPCA61K8/73A61K31/716A61Q11/00A61P1/02
Inventor 郭宏亮叶榛吴佳迪庄秀园王轩朱斌念
Owner ZHEJIANG GLLION BIOTECH CO LTD
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