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Traditional Chinese medicine composition prepared for preventing or treating oral diseases and application of traditional Chinese medicine composition

A technology of composition and traditional Chinese medicine, applied in the directions of drug combination, active ingredient of hydroxyl compound, pharmaceutical formula, etc., can solve the problems of not fundamentally removing disease, inconvenient use, dysbacteriosis, etc.

Active Publication Date: 2019-03-19
SHIJIAZHUANG YILING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although basic periodontal treatment is effective in removing plaque and controlling inflammation, it is difficult to control plaque at an ideal level for a long time
Long-term use of antibiotics throughout the body may lead to adverse consequences such as bacterial imbalance and drug resistance, while the local concentration of the drug is relatively low
Although topical periodontal medication can avoid the possible adverse consequences of systemic medication, it also has disadvantages such as inconvenient use, multiple side effects, and drug resistance.
In addition, most of the various periodontal topical dosage forms at present are mainly antibacterial and bactericidal preparations, or some biofilm preparations can only promote the regeneration of gingival tissue
People gradually realize that Western medicine is only symptomatic treatment to a large extent, but does not fundamentally eliminate the disease, and it is easy to relapse
And the extensive use of antibiotics will inevitably bring about this and that discomfort
For example, the emergence of "side effects and drug resistance" has made many patients ineffective after taking medicine, and has become an incurable disease.

Method used

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  • Traditional Chinese medicine composition prepared for preventing or treating oral diseases and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition prepared for preventing or treating oral diseases and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition prepared for preventing or treating oral diseases and application of traditional Chinese medicine composition

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preparation example Construction

[0081] Forsythia 25.5kg, honeysuckle 25.5kg, fried bitter almond 8.5kg, gypsum 25.5kg, Radix isatidis 25.5kg, Houttuynia cordata 25.5kg, patchouli 8.5kg, rhodiola 8.5kg, menthol 0.75kg, licorice 8.5kg , the preparation method comprises the following steps:

[0082] (1) Weighing: Weigh each medicinal flavor one by one according to the formula ratio;

[0083] (2) Alcohol extraction: Forsythia and Houttuynia cordata were extracted twice with 8 times the amount of 70% ethanol, the first time was 2 hours, the second time was 1.5 hours, the extract was filtered, the filtrates were combined, and the ethanol was recovered until there was no alcohol smell. Alcohol extract;

[0084] (3) Oil extraction: add 6 times the amount of water to Patchouli to extract the volatile oil, extract the oil for 4 hours, collect the volatile oil, filter the extract, concentrate until the relative density is 1.10-1.15 when measured at 60°C, and obtain the volatile oil and patchouli perfume extract;

[...

Embodiment 1

[0089] Embodiment 1: the preparation of lozenge

[0090] The raw materials are as follows: the active ingredients of the traditional Chinese medicine composition: 10g, 50g of lactose, 100g of dextrin, 50g of xylitol, 1g of essence, and 1g of magnesium stearate. The preparation method is as follows: (1) the active ingredients of the Chinese medicine composition The extract is spray-dried to obtain spray powder; (2) Take the spray powder obtained in step (1), put it in a wet mixing granulator, add lactose, dextrin, xylitol and mix evenly, and use 70-80% ethanol Make a suitable soft material, granulate with a 16-mesh screen of a swing granulator, and dry at 60°C. The dried granules are crushed and granulated in a granulator, and granulated with a 1.5mm conical sieve to obtain mixed granules; ( 3) Take the active ingredients volatile oil and menthol of the traditional Chinese medicine composition, add an appropriate amount of ethanol to dissolve, spray the ethanol solution into th...

Embodiment 2

[0091] Embodiment 2: preparation of mouthwash

[0092] The raw materials are as follows: 5 g of active ingredients of the traditional Chinese medicine composition, 5 g of sodium benzoate, 1 g of sodium saccharin, 2 g of polysorbate-20, 2 g of essence, 0.1 g of pigment, and 1000 ml of deionized water. The preparation method is as follows: take the active ingredients menthol and volatile oil of the Chinese medicine composition, dissolve them with an appropriate amount of ethanol, add them to the active ingredients clear ointment of the Chinese medicine composition, dissolve sodium benzoate and sodium saccharin with an appropriate amount of water, and add them to the clear ointment. Add polysorbate-20, essence and pigment, add water to the specified amount, adjust the pH value to 5.0-6.0 with phosphoric acid, stir evenly, let stand, and filter to obtain.

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Abstract

The invention aims to provide a traditional Chinese medicine composition for preventing or treating oral diseases. The traditional Chinese medicine composition comprises fructus forsythiae, flos lonicerae, roasted semen armeniacae amarum, gypsum fibrosum, radix isatidis, herba houttuyniae, herba pogostemonis, radix et rhizoma rhodiolae, menthol and radix glycyrrhizae. The traditional Chinese medicine composition has the advantage that the common oral diseases such as periodontitis, gingivitis, oral ulcer and oral mucositis can be treated by the aid of the traditional Chinese medicine composition.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for preventing or treating oral diseases and its application. Background technique [0002] With the development of medical science, more and more attention has been paid to oral problems, and the oral health of all people in our country has been well improved. However, according to recent surveys, almost everyone in our country has suffered from dental diseases. Oral diseases not only cause damage to teeth, gums, and pulp, but also affect the development of the jaw, forming systemic diseases. There are many types of oral diseases, and it is difficult to prevent them comprehensively. The reason is that the food residues left in the teeth are easy to breed various bacteria. Countries in the world are paying more and more attention to oral diseases, but so far not only many causes are still unclear, but also there ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61P1/02A61K33/06A61K31/045
CPCA61K31/045A61K33/06A61K36/195A61K36/315A61K36/355A61K36/41A61K36/484A61K36/532A61K36/634A61K36/736A61K36/78A61K2236/331A61K2236/333A61K2236/39A61K2236/53A61K2300/00
Inventor 王宏涛王永群许红辉郑晓杰
Owner SHIJIAZHUANG YILING PHARMA
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