System for preparing absorbable polyester and method thereof

A polyester and polymer technology, which is applied in the field of systems for preparing absorbable polyesters, can solve the problems of poor melt stability of polyglycolic acid, large internal and external differences of solids, and uneven heat conduction of materials.

Pending Publication Date: 2021-02-26
SHENZHEN ANTMED CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the polyglycolic acid melt obtained by this method has poor stability, and the material in the glass tube is susceptible to uneven heat conduction, resulting in a large difference between the inside and outside of the generated solid, and the residual monomer content is relatively high.

Method used

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  • System for preparing absorbable polyester and method thereof
  • System for preparing absorbable polyester and method thereof
  • System for preparing absorbable polyester and method thereof

Examples

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preparation example Construction

[0044]The method for preparing absorbable polyester of the present invention adopts bulk polymerization, and the advantage of bulk polymerization over melt polymerization is lower reaction temperature: due to the moderate temperature, side reactions occur to a much smaller extent. Side reactions during polymerization are detrimental on the one hand, since they cause chain termination in the growth reaction, thereby limiting the molecular weight in the polymer, and the molecular weight distribution as well as the residual monomer content are also broadened. Therefore, absorbable polyesters with very high molecular weight can only be produced by bulk polymerization and not in the molten state. The high reaction temperature of melt polymerization also has the disadvantage that the resulting polymer may have some discoloration. These impurities produced at high temperatures are often bound to the polymer and therefore cannot be removed from the product in subsequent purification s...

Embodiment 1

[0089] First, add 2KG of L-lactide (purity above 99.5%), 0.3g of stannous octoate and 3mL of water into the melting tank, then fill it with nitrogen protection and heat and stir. The heating temperature range is 105-110°C. After the solid powder is completely melted, the molten liquid is evenly discharged into the polymerization reactor, filled with nitrogen protection and the valve of the reactor feed port is closed, and the temperature of the polymerization reaction heating plate is set at 170-175°C. L-lactide melt undergoes ring-opening polymerization under the joint action of temperature, catalyst and initiator. When the temperature rises to a constant value, start counting. After 4 hours of heat preservation at this temperature, switch to a low-temperature oil circuit. The temperature of the low-temperature oil circuit is set at 115-120°C. After 8 hours of heat preservation, the reaction is over, and the temperature is naturally lowered, and the temperature is removed from...

Embodiment 2

[0097] Add 5KG of glycolide (GA), 0.25g of stannous chloride (SnCl2) and 5mL of n-dodecyl alcohol into the melting tank, then fill it with nitrogen protection and heat and stir. The heating temperature ranges from 100 to 105°C. After the solid powder is completely melted, the molten liquid is evenly discharged into the polymerization reactor, filled with nitrogen protection and the valve of the reactor feed port is closed, and the temperature of the polymerization reaction heating plate is set at 175-180°C. Glycolide undergoes ring-opening polymerization under the combined action of temperature, catalyst and initiator. When the temperature rises to a constant value, start timing, and switch to the low-temperature oil circuit after holding at this temperature for 2 hours. The temperature of the low-temperature oil circuit is set at 115-120 °C. Take out the yellow sheet-shaped finished polyglycolide (PGA), and then make the PGA into irregular solid particles through physical cru...

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Abstract

The invention discloses a system and a method for preparing absorbable polyester. The system for preparing absorbable polyester comprises a melting tank; and a polymerization reaction device which comprises a polymerization reactor and a polymerization heating plate which are arranged in a stacked mode, and the heating plate is provided with a heating flow channel so as to exchange heat with the polymerization reactor; the polymerization reactor is provided with a reaction cavity, the reaction cavity is communicated with the melting tank, and the shortest distance between cavity walls of the reaction cavity is less than 4cm. According to the technical scheme, a homopolymer of cyclic ester or a copolymer of different cyclic esters can be prepared, and the obtained polyester is high in molecular weight, narrow in molecular weight distribution and less in coloring.

Description

technical field [0001] The invention relates to the technical field of polymer preparation methods, in particular to a system and method for preparing absorbable polyester. Background technique [0002] In recent years, more and more polymer materials have been used by surgeons and pharmacists. When these polymer materials and their degradation by-products are absorbed or metabolized by the human circulatory system, they are defined as bioabsorbable. For example, the ring-opening copolymer of lactide and glycolide, as a known absorbable polyester, has long been used in the field of surgical sutures. [0003] In absorbable polyester, it can be synthesized by dehydration polycondensation of α-hydroxycarboxylic acid such as lactic acid, glycolic acid, etc., but in this method, the molecular weight of the prepared polymer is low, and the physical properties of the polymer are poor, which cannot reach actual use requirements. In order to obtain high-molecular-weight absorbable ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/78C08G63/08C08G63/64
CPCC08G63/08C08G63/64C08G63/785
Inventor 张平吴姗姗王五星
Owner SHENZHEN ANTMED CO LTD
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