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Preparation method of chitosan/sodium alginate composite hydrogel

A technology of composite hydrogel and sodium alginate is applied in the field of preparation of chitosan/sodium alginate composite hydrogel, which can solve the problems of inability to prepare chitosan hydrogel with mechanical properties, and achieves optimized mechanical properties, improved brittle effect

Active Publication Date: 2021-03-16
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chitosan hydrogels with controllable mechanical properties cannot be prepared by prior art

Method used

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  • Preparation method of chitosan/sodium alginate composite hydrogel
  • Preparation method of chitosan/sodium alginate composite hydrogel

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preparation example Construction

[0020] 1) Preparation of chitosan aqueous solution: dissolving chitosan in water, adding methacrylic anhydride dropwise, adjusting pH to 8-10 with sodium bicarbonate solution, stirring evenly to obtain chitosan aqueous solution. Then the chitosan aqueous solution was dialyzed for 1-3 days using a 5-8KD dialysis bag, and then freeze-dried for future use.

[0021] 2) Preparation of sodium alginate aqueous solution: Dissolve sodium alginate in water, add methacrylic anhydride dropwise, adjust pH to 8-10 with sodium hydroxide solution, stir well to obtain sodium alginate aqueous solution. The sodium alginate aqueous solution was dialyzed for 1-3 days with a 5-8KD dialysis bag, and then freeze-dried for later use.

[0022] 3) Preparation of the composite hydrogel: mix the chitosan aqueous solution and the sodium alginate aqueous solution to obtain a mixed solution, add a photoinitiator to the mixed solution, and use a 100W ultraviolet light lamp (ultraviolet intensity 4800μW / cm 2 ...

Embodiment 1

[0031] 1) Preparation of chitosan aqueous solution: dissolving chitosan in water to prepare a solution with a chitosan concentration of 10 g / L. Add methacrylic anhydride 20 times the amount of chitosan substance dropwise, and adjust the pH to 8 with sodium bicarbonate solution, and stir well to obtain a uniform chitosan aqueous solution. The obtained solution was dialyzed for 1-3 days using a 5-8KD dialysis bag, and freeze-dried for future use.

[0032] 2) Preparation of sodium alginate aqueous solution: dissolving sodium alginate in water to prepare a solution with a sodium alginate concentration of 10 g / L. Add methacrylic anhydride which is twice the amount of alginic acid substance dropwise, adjust the pH to 8 with sodium hydroxide solution, and stir thoroughly to obtain a uniform sodium alginate aqueous solution. The obtained solution was dialyzed for 1 to 3 days using a 5-8KD dialysis bag, and then freeze-dried for future use after dialysis.

[0033] 3) Preparation of c...

Embodiment 2

[0037] 1) Preparation of chitosan aqueous solution: dissolving chitosan in water to prepare a solution with a chitosan concentration of 15 g / L. Add methacrylic anhydride 20 times the amount of chitosan substance dropwise, and adjust the pH to 8 with sodium bicarbonate solution, and stir well to obtain a uniform chitosan aqueous solution. The obtained solution was dialyzed for 1-3 days using a 5-8KD dialysis bag, and freeze-dried for future use.

[0038] 2) Preparation of sodium alginate aqueous solution: dissolving sodium alginate in water to prepare a solution with a sodium alginate concentration of 10 g / L. Add methacrylic anhydride which is twice the amount of alginic acid substance dropwise, adjust the pH to 8 with sodium hydroxide solution, and stir thoroughly to obtain a uniform sodium alginate aqueous solution. The obtained solution was dialyzed for 1 to 3 days using a 5-8KD dialysis bag, and then freeze-dried for future use after dialysis.

[0039] 3) Preparation of c...

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Abstract

The invention discloses a preparation method of chitosan / sodium alginate composite hydrogel, which comprises the following steps: mixing a chitosan water solution and a sodium alginate water solutionto obtain a mixed solution, adding a photoinitiator into the mixed solution, and conducting irradiating under ultraviolet light to obtain the chitosan / sodium alginate composite hydrogel. By adding sodium alginate, the brittleness of the chitosan hydrogel can be improved by utilizing sodium alginate with good plasticity and toughness, and the mechanical property of the gel is optimized; and the mechanical property of the hydrogel can be regulated and controlled by controlling the mixing ratio of the chitosan aqueous solution to the sodium alginate aqueous solution, and the breaking strength ofchitosan can be increased from 2 MPa to 6 MPa to the maximum extent. Meanwhile, the prepared chitosan / sodium alginate composite hydrogel has the antibacterial property of chitosan and the biological activity of sodium alginate. The hydrogel is loaded on the surface or inside an implant, and is expected to be widely applied to the fields of antibacterial dressings and drug controlled release.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a preparation method of chitosan / sodium alginate composite hydrogel. Background technique [0002] Chitosan has good biocompatibility, biodegradability and antibacterial properties, and is often used as a medical dressing and drug sustained-release carrier, but its mechanical properties are poor. Sodium alginate is a good bioactive material, and its hydrogel has certain strength and good toughness. Mixing sodium alginate and chitosan solution to prepare composite hydrogel can improve the mechanical properties of chitosan and endow the gel with more biological functions. The prior art cannot prepare chitosan hydrogel with controllable mechanical properties. Contents of the invention [0003] The purpose of the present invention is to provide a kind of preparation method of chitosan / sodium alginate composite hydrogel in order to solve the problems in the prior art, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F299/00C08F2/48C08J3/075C08L55/00
CPCC08F2/48C08F299/00C08J3/075C08J2355/00
Inventor 周睿周颖李明靳国瑞程嘉辉憨勇
Owner XI AN JIAOTONG UNIV
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