Novel long noncoding RNA gene and application thereof to preparation of reagent for detecting or diagnosing early melanosis

A long-chain non-coding, melanosis technology, applied in the biological field, can solve problems such as the unclear pathogenesis of human melanosis, and achieve the effects of difficult detection, wide application range, and small content of detection objects
CN112553208APending Publication Date: 2021-03-26CHONGQING ACAD OF ANIMAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHONGQING ACAD OF ANIMAL SCI
Publication Date
2021-03-26

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Abstract

The invention also provides a novel long noncoding RNA gene, and the sequence of the novel long noncoding RNA gene is shown as SEQ ID NO.1. The invention also provides an application of the novel longnoncoding RNA gene to preparation of a reagent for detecting or diagnosing early melanosis, and also provides tissue expression characteristics, melanogenesis promoting effect and action mechanism ofthe new gene, thereby providing a theoretical basis for development of clinical medicines for treating melanosis in the next step. The novel long noncoding RNA provided by the invention can be used for early clinical detection of various melanosis diseases so as to facilitate early intervention of diseases, is not limited to melanoma, can also be used for early clinical detection and prevention of various melanosis diseases with tissue melanin hyperplasia, and is wider in application range.
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Description

technical field

[0001] The invention belongs to the field of biology, and in particular relates to a long-chain non-coding RNA and its application. Background technique

[0002] Long noncoding RNA (long noncoding RNA, lncRNA) is a class of transcripts longer than 200 nucleotides that cannot encode proteins, and is mainly involved in the regulation of gene expression. Studies have shown that it can participate in many important regulatory processes such as X chromosome inactivation and transcription, chromatin modification, genome imprinting, interfering with gene promoters, inducing histone modification, protein activity regulation, and nuclear transport. Gene regulation, signal pathways, transcriptional and post-transcriptional regulation of protein-coding gene expression are involved in gene expression and regulation. At present, it has been confirmed that the occurrence and development of various diseases, the transformation, invasion and metastasis of different tumor ce...

Claims

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