A kind of multi-component double-layer composite nano film dressing and its production method

Abstract

The invention discloses a multi-component double-layer composite nano film dressing and a production method thereof, comprising: an upper layer dressing and a lower layer dressing, the upper layer dressing is arranged above the lower layer dressing, and the upper layer dressing includes polylactic acid and tea polyphenols , wherein polylactic acid and tea polyphenols are electrospun to obtain a nano-film-like upper dressing, and the lower dressing includes polylactic acid and hyaluronic acid, wherein polylactic acid and hyaluronic acid are electrospun to obtain a nano-film-like dressing Lower dressing. Through the above method, the multi-component double-layer composite nano-film dressing and its production method according to the present invention, the addition of tea polyphenols in the upper dressing makes up for the deficiency in the function of single polylactic acid nanofibers, and gives excellent broad-spectrum antibacterial properties. , anti-oxidation, anti-mutation and other properties, the addition of hyaluronic acid in the lower dressing improves the deficiency of the upper dressing in terms of water absorption and ventilation, making the material more skin-friendly, and its good biological activity can effectively promote wound healing.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a multi-component double-layer composite nano film dressing and a production method thereof. Background technique [0002] With the development of medical technology, there are many kinds of wound dressings, such as silver dressings, chitin dressings, hydrogel and alginic acid dressings, natural polymer dressings and synthetic polymer dressings, etc. Wound dressings have their own advantages. But there are also deficiencies. [0003] Among them, silver-containing dressings can be in direct contact with the wound, and have outstanding anti-infection effects, but are relatively expensive; chitin-based dressings can actively promote the growth of wound cells and are easy to use, but the penetration effect of chitin-based dressings is not good, and the anti-infection The effect is average; hydrogel and alginic acid dressings are safe and convenient to use, and have good absorptio...

AI Technical Summary

Problems solved by technology

[0003] Among them, silver-containing dressings can be in direct contact with the wound, and have outstanding anti-infection effects, but are relatively expensive; chitin-based dressings can actively promote the growth of wound cells and are easy to use, but the penetration effect of chitin-based dressings is not good, and the anti-infection The effect is average; hydrogel and alginic acid dressings are safe and convenient to use, and have good absorption and moisturizing effect, but the antibacterial effect is average, and the cost performance is not high; although natural polymer dressings are biocompatible, biodegradable, moisture-absorbing and breathable, they are There are still deficiencies in mechanical properties and multifunctionality; although synthetic polymer dressings have good formability, easy processing, and excellent mechanical properties, they are deficient in biocompatibility and cytotoxicity and need to be improved.