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Cefaclor bulk drug

A technology of cefaclor and raw materials, applied in the field of cefaclor raw materials, can solve the problems of incomplete crystallization, poor fluidity and compressibility of raw materials, and poor crystallization effect, so as to improve mixing efficiency and crystallization Full, good fluidity and compressibility effect

Inactive Publication Date: 2021-03-30
苏州盛达药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide cefaclor bulk drug, to solve the problem of insufficient crystallization in the preparation process of the existing cefaclor bulk drug proposed in the above-mentioned background technology, poor crystallization effect and the fluidity and compressibility of the prepared bulk drug. sexual problems

Method used

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Embodiment Construction

[0019] Next, the technical solutions in the embodiments of the present invention will be described below in conjunction with the embodiments of the present invention, and it is clear that the described embodiments are merely the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, there are all other embodiments obtained without making creative labor without making creative labor premises.

[0020] The present invention provides a technical solution: a cefaclo raw material, consisting of a component: 7-amino-3-chlorophyric acid, nitrogen-containing organic alkali salt, phenylene dermnate and specialty chloride, characterized in that The production steps are as follows:

[0021] S1: 7-amino-3-chlorophyric acid with nitrogen-containing organic alkali-containing salts and dissolved in an organic solvent, mixed with the organic solvent using a stirring equipment, stir for 5 min, resulting in 7-amino-3-chlorine Cephara-sol...

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PUM

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Abstract

The invention discloses a cefaclor bulk drug, which is produced by the following steps: S1, salifying 7-amino-3-chloro cephalosporanic acid and nitrogen-containing organic base, dissolving in an organic solvent, and uniformly stirring the organic solvent by using stirring equipment for 5 minutes to obtain a 7-amino-3-chloro cephalosporanic acid solution; S2, dissolving phenylglycine dane salt andpivaloyl chloride which serve as raw materials into an organic solvent, adding a catalyst into the organic solvent to obtain a mixed anhydride solution, and pressurizing and injecting the catalyst into the organic solvent under the action of a water pump; and S3, carrying out acylation condensation reaction on the 7-amino-3-chloro cephalosporanic acid dissolving solution and the mixed anhydride solution under the action of a catalyst, adding acid for hydrolysis, and carrying out phase splitting to obtain an aqueous solution of cefaclor and acid salifying. According to the cefaclor raw materialmedicine, the superfine silica powder and the magnesium stearate are added, so that prepared particles have good fluidity and compressibility; and a double crystallization mode is adopted, so that the crystallization effect of the medicine is ensured, and the crystallization is more complete.

Description

Technical field [0001] The present invention relates to the technical field of cefaclo raw materials, and is specifically a cefaclo raw material. Background technique [0002] Cefocilo raw materials are white to micro-yellow powder or crystalline powder; smear. The product is slightly soluble in water, almost insoluble in methanol, ethanol, chloroform or dichloromethane, the action mechanism of the product is to inhibit the synthesis of bacterial cell walls. [0003] The existing crystallization in the preparation of Ceantoli raw materials is not complete, and the fluidity and pressure resistance of the crystallization effect are not good and the raw material is poor. Inventive content [0004] It is an object of the present invention to provide a cephalo raw material to solve the crystallization in the presence of the conventional cefaclo raw materials proposed in the above background, and the crystallization of the crystalline is not complete, the crystalline effect is not goo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D501/59C07D501/06
CPCC07D501/06C07D501/59
Inventor 周自金黄军豪
Owner 苏州盛达药业有限公司
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