Antibody targeting BCMA, bispecific antibody and uses of antibody targeting BCMA and bispecific antibody

A bispecific antibody and targeting technology, applied in the direction of antibodies, antibody medical components, anti-receptor/cell surface antigen/cell surface determinant immunoglobulin, etc., can solve light chain mismatch and heterodimerization and other issues to achieve the effect of optimizing activity, reducing toxicity and long half-life
CN112574308AInactive Publication Date: 2021-03-30NONA BIOSCIENCES CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NONA BIOSCIENCES CO LTD
Publication Date
2021-03-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an antibody targeting BCMA, a bispecific antibody targeting BCMA and CD3, and applications of the antibody and the bispecific antibody. The antibody targeting the BCMA comprises two heavy chain variable regions, wherein the heavy chain variable regions comprise HCDR1, HCDR2 and HCDR3 which are respectively shown as amino acid sequences of SEQ ID NO: 22, SEQ ID NO: 33 and SEQ ID NO: 42, or HCDR1, HCDR2 and HCDR3 shown as amino acid sequences of SEQ ID NO: 26, SEQ ID NO: 37 and SEQ ID NO: 41 respectively. The antibody provided by the invention effectively targets human BCMA and is combined with cynomolgus monkey BCMA; and the bispecific antibody effectively targets human BCMA and human CD3 at the same time, and can be combined with cynomolgus monkey BCMA and cynomolgus monkey CD3.
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Description

technical field

[0001] The invention relates to the field of biopharmaceuticals, in particular to an antibody targeting BCMA, a bispecific antibody and uses thereof. Background technique

[0002] BCMA (B-cell maturation antigen, TNFRSF17, CD269) is a transmembrane protein belonging to the TNF receptor superfamily. BCMA is a non-glycosylated transmembrane protein involved in B cell maturation, growth and survival. BCMA is the receptor for two ligands of the TNF superfamily: the high-affinity ligand APRIL (proliferation-inducing ligand) and the low-affinity ligand BAFF (B-cell activating factor). BCMA is a highly differentiated plasma cell-selective protein whose expression is restricted to the B-cell lineage and is present primarily on plasma cells and plasmablasts and to some extent on memory B-cells, but not in the periphery on B-cells. BCMA is expressed in malignant plasma cells of multiple myeloma (MM) patients and supports the growth and survival of MM cells. [0003...

Claims

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