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A kind of modified hydrogel, modified hydrogel microsphere and preparation method and application thereof

A technology of gel microspheres and modified water, applied in the field of hydrogel, to achieve the effects of good biocompatibility, free radical scavenging, good biocompatibility and degradability

Active Publication Date: 2021-11-09
SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far, this technology is still blank in the direction of exosome transplantation for the treatment of NIED

Method used

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  • A kind of modified hydrogel, modified hydrogel microsphere and preparation method and application thereof
  • A kind of modified hydrogel, modified hydrogel microsphere and preparation method and application thereof
  • A kind of modified hydrogel, modified hydrogel microsphere and preparation method and application thereof

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Effect test

Embodiment 1

[0037] Prepare 100mL 2%w / v sodium alginate solution, add 100mL 1%w / v fucoidan, stir to dissolve, add dropwise 50mL 3%w / v calcium chloride solution, prepare calcium alginate / fucoidan with a double-barreled syringe Sugar hydrogel (AF1). figure 1 It is a schematic diagram of the formation of alginic acid / fucose gel hydrogel.

Embodiment 2

[0039]Prepare 100mL 2%w / v sodium alginate solution, add 100mL 3%w / v fucoidan, stir to dissolve, add dropwise 50mL 3%w / v calcium chloride solution, prepare calcium alginate / fucoidan with a double-barreled syringe Sugar hydrogel (AF2).

Embodiment 3

[0041] Prepare 100mL 2%w / v sodium alginate solution, add 100mL 5%w / v fucoidan, stir to dissolve, add dropwise 50mL3%w / v calcium chloride solution, prepare calcium alginate / fucoidan with a double-barreled syringe Sugar hydrogel (AF3).

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Abstract

The invention proposes a modified hydrogel, a modified hydrogel microsphere and its preparation method and application, belonging to the field of hydrogel technology, and the modified hydrogel is calcium alginate / fucoidan hydrogel Gel, obtained by cross-linking sodium alginate and fucoidan in the presence of calcium ions; the mass ratio of sodium alginate and fucoidan is 2: (1‑5), and the modified hydrogel microsphere , the modified hydrogel has a shell-core structure, with silica as the shell and calcium alginate / fucoidan hydrogel as the core, and the particle size of the microspheres is between 200-250nm, preferably 220nm -240nm. The preparation method of the invention is simple, the source of raw materials is wide, the prepared modified hydrogel has biocompatibility and degradability, and after microsphereization, the storage time of the hydrogel can be significantly improved, and the transportation is convenient.

Description

technical field [0001] The invention relates to the technical field of hydrogels, in particular to a modified hydrogel, modified hydrogel microspheres and a preparation method and application thereof. Background technique [0002] Mesenchymal stem cell therapy can effectively improve nerve-injured erectile dysfunction (NIED), which plays a role by improving endothelial cells, smooth muscle, and promoting cavernous nerve repair; injecting DDAH2 gene-modified stem cells into erectile dysfunction (erectile dysfunction) , ED) The corpus cavernosum of rats, which can effectively improve their erectile function. Studies have confirmed that stem cells function more through paracrine effects than their own differentiation functions. There is a certain substance in the culture supernatant of stem cells, which is even stronger than the stem cells themselves to exert a powerful function. At present, it is believed that the active ingredient is mainly exosomes, which transduce biologic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/36A61K35/28A61P25/00A61P15/10
CPCA61K9/0019A61K9/06A61K35/28A61K47/36A61P15/10A61P25/00
Inventor 刘帅
Owner SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY
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