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Modified hydrogel, modified hydrogel microsphere and preparation method and application thereof

A technology of gel microspheres and modified water, applied in the field of hydrogel, to achieve the effect of promoting the formation of typical granulation tissue, good biocompatibility and degradability, and good degradability

Active Publication Date: 2021-04-09
SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far, this technology is still blank in the direction of exosome transplantation for the treatment of NIED

Method used

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  • Modified hydrogel, modified hydrogel microsphere and preparation method and application thereof
  • Modified hydrogel, modified hydrogel microsphere and preparation method and application thereof
  • Modified hydrogel, modified hydrogel microsphere and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Prepare 100mL 2%w / v sodium alginate solution, add 100mL 1%w / v fucoidan, stir to dissolve, add dropwise 50mL 3%w / v calcium chloride solution, prepare calcium alginate / fucoidan with a double-barreled syringe Sugar hydrogel (AF1). figure 1 It is a schematic diagram of the formation of alginic acid / fucose gel hydrogel.

Embodiment 2

[0039]Prepare 100mL 2%w / v sodium alginate solution, add 100mL 3%w / v fucoidan, stir to dissolve, add dropwise 50mL 3%w / v calcium chloride solution, prepare calcium alginate / fucoidan with a double-barreled syringe Sugar hydrogel (AF2).

Embodiment 3

[0041] Prepare 100mL 2%w / v sodium alginate solution, add 100mL 5%w / v fucoidan, stir to dissolve, add dropwise 50mL3%w / v calcium chloride solution, prepare calcium alginate / fucoidan with a double-barreled syringe Sugar hydrogel (AF3).

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Abstract

The invention provides modified hydrogel, a modified hydrogel microsphere and a preparation method and application thereof, and belongs to the technical field of hydrogel. The modified hydrogel is calcium alginate / fucoidin hydrogel, and is obtained by crosslinking sodium alginate and fucoidin in the presence of calcium ions; and the mass ratio of the sodium alginate to the fucoidin is 2: (1-5), the modified hydrogel microsphere and the modified hydrogel are of a shell-core structure, silicon dioxide is used as a shell, the calcium alginate / fucoidin hydrogel is used as a core, and the particle size of the microsphere is 200-250nm, preferably 220-240nm. The preparation method is simple, a raw material source is wide, the prepared modified hydrogel has biocompatibility and degradability, after microballing, the preservation time of the hydrogel can be remarkably prolonged, and transportation is convenient.

Description

technical field [0001] The invention relates to the technical field of hydrogels, in particular to a modified hydrogel, modified hydrogel microspheres and a preparation method and application thereof. Background technique [0002] Mesenchymal stem cell therapy can effectively improve nerve-injured erectile dysfunction (NIED), which plays a role by improving endothelial cells, smooth muscle, and promoting cavernous nerve repair; injecting DDAH2 gene-modified stem cells into erectile dysfunction (erectile dysfunction) , ED) The corpus cavernosum of rats, which can effectively improve their erectile function. Studies have confirmed that stem cells function more through paracrine effects than their own differentiation functions. There is a certain substance in the culture supernatant of stem cells, which is even stronger than the stem cells themselves to exert a powerful function. At present, it is believed that the active ingredient is mainly exosomes, which transduce biologic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/36A61K35/28A61P25/00A61P15/10
CPCA61K9/0019A61K9/06A61K35/28A61K47/36A61P15/10A61P25/00
Inventor 刘帅
Owner SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY
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