Preparation method of thin-wall large-scale soft microcapsule based on bubble method

Abstract

The invention discloses a preparation method of a thin-wall large-scale soft microcapsule based on a bubble method, which belongs to the technical field of biological medicines and comprises the following steps: 1) uniformly dispersing bovine serum albumin microbubbles with negative charges on the surface; and 2) sequentially assembling a polyallylamine hydrochloride solution and a sodium polystyrenesulfonate solution on the surfaces of the microbubbles layer by layer, and leaving the thin-wall large-scale soft microcapsules. The method overcomes the defects that the polymer electrolyte capsule has small size (<15um) and the additional nucleolysis treatment can influence the further use of the capsule; meanwhile, the defects that the large-size capsules prepared by an emulsion method including a micro-flow control method have wall thickness and permeability which are difficult to control are overcome; and according to the preparation method of the thin-wall large-scale soft microcapsule based on the bubble method, the thin-wall large-scale capsule is prepared by a layer-by-layer self-assembly method, the operation is simple and convenient, the preparation time is short, and the required equipment is simple.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a method for preparing thin-walled large-scale soft microcapsules based on an air bubble method. Background technique [0002] As microcapsules are widely used in biomedicine, cosmetics, food and other fields, for example, microcapsules can be used as drug carriers to achieve controlled release of drugs. [0003] Nowadays, a variety of preparation methods of microcapsules have been developed, among which the size of polyelectrolyte capsules prepared by dropping cationic polyelectrolyte solution into anionic polyelectrolyte solution is limited, and it is difficult to exceed 15um. At the same time, the nuclear dissolution operation makes the concentration of the capsule core residue temporarily high, which generates osmotic pressure and expands the capsule, resulting in high mechanical pressure on the polyelectrolyte capsule and nuclear residues that will affect the...

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Problems solved by technology

At the same time, the nuclear dissolution operation makes the concentration of residues in the core of the capsule temporarily higher, which generates osmotic pressure and expands the capsule, resulting in high mechanical pressure on the polyelectrolyte capsule and nuclear residues that will affect the further use of the capsule.

[0004] Although large-sized capsules can be prepared by emulsion methods including microfluidic methods, the walls of the capsules are too thick, usually greater than 20um, and the permeability of such capsules is difficult to control, which limits its application in biomedicine and other fields.

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