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Endogenous photothermal therapy device system with micro-nano quantum dots and preparation method of system

A technology of photothermal therapy and quantum dots, applied in phototherapy, microsphere preparation, chemical instruments and methods, etc., can solve the problems of difficult self-aggregation and low penetration depth of photoconversion reagents, and solve the problem of light transmission loss and light tissue The effect of too short a penetration depth

Pending Publication Date: 2021-04-20
BEIJING UNIV OF TECH
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Problems solved by technology

[0004] In order to solve the problems of low tissue penetration depth of photothermal therapy and difficult self-aggregation of photoconversion reagents, a new photothermal therapy treatment mode mechanism was designed, and a new type of micro-nano quantum dot endogenous photothermal therapy device was invented and developed. system, the system uses the new CdTe@CdSe@ZnS double-shell core-shell quantum dots as the optical gain medium to construct a fiber optic ring resonant cavity to obtain high-intensity near-infrared light radiation output; the light source device can also carry near-infrared photothermal reagents Simultaneously reach the lesion area directly, and realize the controllable micro-area photothermal therapy targeting cancer with high precision through the regulation of the range of action of the photothermal reagent

Method used

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Embodiment 1

[0062] Step 1: Preparation of CdTe core by aqueous phase synthesis

[0063] Add more than 150 μL of 0.5 mmol / mL excess NaHTe solution to the N-containing 2 Saturated 0.25mmolCd(NO 3 ) 2 In the solution, use NaOH to adjust the pH value to 8, and add 0.625mmol glutathione (GSH) as a stabilizer, Cd 2+ / HTe - The molar ratio of GSH / GSH was fixed at 4:1:10; a small amount of ammonia was added to the solution as an additional stabilizer and pH controller to obtain CdTe core nanocrystals;

[0064] Step 2: Preparation of CdSe intermediate shell by continuous ion layer adsorption reaction technique (SILAR)

[0065] 0.4mmol NaBH 4 Excess dissolved in 4ml water, in N 2 Next, add 0.25 mmol of Se powder to obtain NaHSe solution, namely Se precursor solution; the CdTe nuclear nanocrystals purified in step (1) are suspended in degassed water, and the pH value is adjusted to 10 with NaOH; 0.3 mmol of Cd ( NO 3 ) 2 "4H 2 O and greater than 0.75mmol glutathione (GSH) constitute Cd 2+...

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Abstract

The invention discloses an endogenous photothermal therapy device system of micro-nano quantum dots and a preparation method of the system, and belongs to the field of micro-nano quantum dot photoelectric devices for minimally invasive medical treatment. CdTe@CdSe@ZnS double-layer shell core-shell quantum dots are used as an optical gain medium and are used for filling into an optical fiber annular resonant cavity constructed by a liquid core optical fiber or an ultrafine capillary tube to obtain a high-intensity near-infrared light radiation output light source device, namely a CdTe@CdSe@ZnS double-layer shell core-shell quantum dot liquid core optical fiber probe; and the optical fiber with the CdTe@CdSe@ZnS double-layer shell core-shell quantum dot liquid core optical fiber probe is connected with an excitation light source through a light guide optical fiber or a light guide optical fiber and an optical fiber jumper wire to form the endogenous photothermal therapy device system with the CdTe@CdSe@ZnS double-layer shell core-shell quantum dots. The system provides a new thought and a novel micro-nano semiconductor optical device system for photothermal therapy application, and provides a novel optical diagnosis and treatment method and instrument for the field of cancer treatment.

Description

technical field [0001] The invention belongs to the field of micro-nano quantum dot optoelectronic devices for minimally invasive medical treatment, and specifically relates to a novel CdTe@CdSe@ZnS double-shell core-shell quantum dot micro-nano quantum dot endogenous photothermal treatment device system and a preparation method. Background technique [0002] Cancer is the leading cause of morbidity and mortality worldwide, with approximately 14 million cancer patients and 8 million deaths from cancer-related diseases each year. Hyperthermia is widely recognized as a minimally invasive cancer treatment strategy. It refers to the application of different physical factors (radio frequency, microwave, ultrasound, and laser, etc.) to increase the temperature of tumor tissue or the whole body, and to treat tumors by using high-temperature killing and its secondary effects. Tumor hyperthermia is divided into superficial hyperthermia, deep hyperthermia, whole body hyperthermia and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61P35/00B82Y5/00C09K11/02C09K11/88B82Y20/00B82Y30/00B82Y40/00A61N5/06
CPCA61N5/06B01J13/02B82B3/00B82Y20/00C09K11/56C09K11/88G02F1/01A61K41/00A61P35/00B82Y5/00B82Y30/00B82Y40/00C09K11/02
Inventor 苏雪琼王丽王进赵鹏翔吕青鸿
Owner BEIJING UNIV OF TECH
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