Preparation method of vincamine

A technology of vincamine and tabonin, which is applied in the preparation of compounds and the green production of vincamine, which can solve the problems of low production efficiency, long reaction time, and low degree of industrialization, and achieve safety issues and less manual operations , the effect of large specific surface area

Active Publication Date: 2021-04-20
ZHANG JIA GANG VINSCE BIO PHARM
View PDF4 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] (1) When preparing vincamine, the reaction time is longer, the impurities are large, and the purity and yield of the product are not high enough;
[0009] (2) Batch-type production equipment is adopted, and there are many

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of vincamine
  • Preparation method of vincamine
  • Preparation method of vincamine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0043] A preparation method of vincamine, comprising the following steps:

[0044] (1) Reduction: after nitrogen and hydrogen have replaced the microchannel reactor successively, the mixed solution of bonin and methyl alcohol and hydrogen are passed into the microchannel reactor 5 loaded with porous palladium catalyst by the feeding pump to carry out the reduction reaction, Set the reaction pressure to 0.8-1.2MPa, and the reaction temperature to 70-100°C; after the reaction is completed, the reaction liquid enters the neutralization tank 7, adjusts the pH to 6 with acetic acid, then filters through the filter 10, and the filtrate enters the stirring tank 12 to concentrate and mix Dichloromethane carries out extraction twice, obtains extract; Wherein step (1) specific experimental parameter value is as shown in table 1:

[0045] Table 1

[0046]

[0047] (2) Oxidation: the extract in the stirred tank 12 is passed into the reactor 14, then an oxidizing agent is added in the re...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a green preparation method of vincamine, which comprises the following steps: (1) reduction: introducing a tabersonine methanol solution and hydrogen into a micro-channel reactor through a charging pump to react, and filtering, concentrating and extracting the reaction solution twice after the reaction is finished, thereby obtaining an extracting solution; (2) oxidation: catalyzing an organic phase in the extraction liquid in the step (1) by using peroxy acid to carry out oxidation reaction, neutralizing by using a sodium bicarbonate solution after the reaction is finished, extracting and concentrating; and (3) rearrangement: dissolving the concentrated solid obtained in the step (2) with ethanol, rearranging in the presence of a catalyst, adjusting the pH value after the reaction is completed, filtering, washing and crystallizing the filter cake, and separating out the solid, namely vincamine. The preparation method is safe, environmentally friendly and capable of achieving continuous production, the product purity is 99% or above, automatic equipment can be adopted for continuous production, and the industrial production efficiency is improved.

Description

technical field [0001] The invention belongs to the field of organic chemistry or medicinal chemistry, and relates to a preparation method of a compound, in particular to a green preparation method of vincamine. Background technique [0002] Vincamine (vincamine) is a main alkaloid in Vinca minor, and it is a quinine in the monoterpene indole alkaloids. Its chemical name is (3α, 14β, 16α)-14,15-di Hydrogen-14-hydroxyivorene-14-carboxylate methyl ester, white powder. In 1953, Schlittle and Furlenmeier isolated vincamine from V.minor. [0003] Vincamine is suitable for cerebrovascular sclerosis, brain insufficiency, and eye, ear, nose, and laryngeal vascular diseases. It is especially suitable for the early manifestations of progressive brain insufficiency, such as dizziness, headache, memory loss, fatigue, and inability to concentrate. In addition, it also has a certain effect on retinal vascular sclerosis and cochlear disorders caused by blood vessels such as dizziness an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07D461/00B01J19/00
Inventor 彭学东张梅赵金召
Owner ZHANG JIA GANG VINSCE BIO PHARM
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap