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New application of asperulosidic acid in promotion of gastrointestinal peristalsis

A technology of cartilidin and gastrointestinal peristalsis, which is applied in the field of medicine and can solve problems such as unseen

Pending Publication Date: 2021-04-23
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no relevant report on its promotion of gastrointestinal motility

Method used

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  • New application of asperulosidic acid in promotion of gastrointestinal peristalsis
  • New application of asperulosidic acid in promotion of gastrointestinal peristalsis
  • New application of asperulosidic acid in promotion of gastrointestinal peristalsis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Study on the Spectrum-Effect Relationship of Glycyrrhizae Promoting Gastrointestinal Motility

[0029] 1 material

[0030] 1.1 Medicinal materials

[0031] See Table 1 for the information of 20 batches of Tomentosa medicinal materials, which were identified as Paederia scandens (Lour.) Merr. or Paederia scandens (Lour.) Merr.var.tomentosa (Bl. ) Dry aerial part of Hand.-Mazz.

[0032] Table 1 Information of 20 batches of Chiya Teng medicinal materials

[0033]

[0034] 1.2 Reagents and instruments

[0035] 1.2.1 Reagents

[0036] Aspirin enteric-coated tablets (Yabao Pharmaceutical Taiyuan Pharmaceutical Co., Ltd., Zhunzi H14024002); atropine sulfate injection (Henan Runhong Pharmaceutical Co., Ltd., specification 0.5mg / mL, batch number 1409262). Analytical grade ethanol, glacial acetic acid and sodium carboxymethylcellulose (Chengdu Kelong Chemical Reagent Factory); acetonitrile was chromatographically pure (Fisher, USA), and water was homemade ultrap...

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Abstract

The invention provides an application of asperulosidic acid or a pharmaceutically acceptable salt thereof in preparation of a medicine for promoting gastrointestinal peristalsis. The medicine is a common preparation prepared from the asperulosidic acid or the pharmaceutically acceptable salt thereof as an active ingredient by adding pharmaceutically acceptable auxiliary materials or auxiliary ingredients. Spectral effect analysis of paederia scandens shows that the asperulosidic acid can improve the gastric emptying rate and the small intestine propulsion rate, and the clinical prospect is excellent.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a new application of cartilidic acid for promoting gastrointestinal motility. Background technique [0002] Asperulosidic acid (1) is an active substance of iridoid glycosides produced by plant metabolism. It is mainly found in Rubiaceae plants, such as Galliphyllum, Hedyotis diffusa and Morinda officinalis. It has anti-tumor, anti- Oxidation, anti-distortion, hypolipidemic and other activities. [0003] [0004] So far, there are no relevant reports on its promotion of gastrointestinal motility. Through the research on the spectrum-effect relationship of the vine, the present inventors found that glucosidic acid is highly correlated with the gastrointestinal peristalsis-promoting effect of the vine. Contents of the invention [0005] The invention provides a use of pyridinic acid or a pharmaceutically acceptable salt thereof in the preparation of a drug for promoting g...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P1/14A61K36/74G01N30/02G01N30/06
CPCA61K31/7048A61P1/14A61K36/74G01N30/02G01N30/06G01N2030/047
Inventor 蒋桂华胡明勋马羚高天元邓薇蒋运斌梁淞婷黄凤连艳艾莉陈玲尹显梅杜华李凤超李惠敏
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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