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Application of hypericin in preparation of medicines for treating fungal skin diseases

A fungal skin disease, hypericin technology, applied in the field of medicine, can solve problems such as easy recurrence, long treatment cycle, and poor treatment effect

Active Publication Date: 2021-04-30
袁小英 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for some refractory fungal infections such as pyophysis, refractory onychomycosis, fungal infectious granuloma and subcutaneous fungal infection, the response to drug treatment is poor, the treatment cycle is long, drug-induced liver damage and other toxic and side effects are prone to occur, and the therapeutic effect Poor and very repeatable

Method used

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  • Application of hypericin in preparation of medicines for treating fungal skin diseases
  • Application of hypericin in preparation of medicines for treating fungal skin diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Utilizing hypericin to prepare a drug for treating fungal skin diseases-hypericin nano-micelle silk gel, the preparation method comprises the following process steps:

[0037] a, the hypericin and vitamin E succinate-graft-ε-polylysine polymer that mass ratio is 1:2 are dissolved in the dimethylformamide solution that concentration is 5mg / ml, obtain gold A mixed solution with a sericin concentration of 1 wt%; slowly drop the mixed solution into deionized water equivalent to 50 times the volume of the mixed solution, self-assemble at 1000r / min, 25°C under light-proof conditions for 10h, after the assembly is completed Move to the dialysis bag (the relative molecular mass cut-off is 3600D), dialyze and centrifuge with distilled water, remove unwrapped free hypericin and vitamin E succinate-graft-ε-polylysine polymer, and obtain the Hypericin nano-micelle;

[0038] b. Boil silkworm cocoons in 12g / L sodium carbonate solution, then wash with distilled water to remove impuri...

Embodiment 2

[0041] Utilizing hypericin to prepare a drug for treating fungal skin diseases-hypericin nano-micelle silk gel, the preparation method comprises the following process steps:

[0042] a, the hypericin and vitamin E succinate-graft-ε-polylysine polymer that mass ratio is 1:4 are dissolved in the dimethylformamide solution that concentration is 10mg / ml, obtain gold A mixed solution with a sericin concentration of 2wt%; slowly drop the mixed solution into deionized water equivalent to 100 times the volume of the mixed solution, self-assemble at 1100r / min, 28°C under dark conditions for 12h, after the assembly is completed Move to the dialysis bag (the relative molecular mass cut-off is 3600D), dialyze and centrifuge with distilled water, remove unwrapped free hypericin and vitamin E succinate-graft-ε-polylysine polymer, and obtain the Hypericin nano-micelle;

[0043] b. Boil silkworm cocoons in 15g / L sodium carbonate solution, then wash with distilled water to remove impurities t...

Embodiment 3

[0046] Utilizing hypericin to prepare a drug for treating fungal skin diseases-hypericin nano-micelle silk gel, the preparation method comprises the following process steps:

[0047] a, the hypericin and vitamin E succinate-graft-ε-polylysine polymer that mass ratio is 1:8 are dissolved in the dimethylformamide solution that concentration is 20mg / ml, obtain gold A mixed solution with a sericin concentration of 4wt%; slowly drop the mixed solution into deionized water equivalent to 200 times the volume of the mixed solution, self-assemble at 1200r / min, 30°C under light-proof conditions for 15h, after the assembly is completed Move to the dialysis bag (the relative molecular mass cut-off is 3600D), dialyze and centrifuge with distilled water, remove unwrapped free hypericin and vitamin E succinate-graft-ε-polylysine polymer, and obtain the Hypericin nano-micelle;

[0048] b. Boil silkworm cocoons in 17g / L sodium carbonate solution, then wash with distilled water to remove impurit...

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Abstract

The invention relates to the technical field of medicines, and particularly discloses application of hypericin in preparation of medicines for treating fungal skin diseases. The invention provides a new application of hypericin in preparation of a medicine for treating fungal skin diseases, and researches find that the medicine for treating fungal skin diseases prepared from hypericin not only has a high cure rate on fungal skin diseases, but also has the advantages of small side effect and low recurrence rate compared with other oral and external medicines, and has a wide application prospect in the field of medicine for treating fungal skin diseases. A new breakthrough point is provided for treatment of fungal skin diseases.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of hypericin in the preparation of medicines for treating fungal skin diseases. Background technique [0002] Hypericin is a natural photosensitizer isolated from Hypericum plants, which can induce apoptosis of cancer cells and inhibit their growth after light activation to produce peroxides. At the same time, it has a special affinity for tumor tissues. It can preferentially accumulate in tumor tissue, and this physiological activity has been widely used in optical diagnosis. At present, hypericin is mainly used in the treatment of tumor diseases such as liver cancer and laryngeal cancer. [0003] Fungal dermatosis refers to superficial infectious diseases of human skin, mucous membranes, hair, and nail and other skin appendages caused by fungi, which are mostly vesicular and scaly clinically. The common features of these diseases are: high incidence, contagio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K31/122A61K36/38A61K9/06A61K47/34A61K47/42A61P17/00A61P31/10
CPCA61K41/0057A61K31/122A61K36/38A61K9/06A61K47/34A61K47/42A61P17/00A61P31/10Y02A50/30
Inventor 袁小英张国强邵丽芳王千陈睿康
Owner 袁小英
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