Degradable chitosan-based composite hemostatic film

A chitosan and film technology, applied in coating, medical science, absorbent pads, etc., can solve the problems of easy aggregation of powder, hemostatic effect, secondary injury material comfort, leakage, etc., achieve excellent anti-infection function, promote The effect of wound healing and avoidance of vascular embolism

Active Publication Date: 2021-04-30
HENAN YADU IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, in order to improve the mechanical strength of the material when preparing chitosan composite materials, most of them need to use cross-linking agents, such as terephthalaldehyde, adipaldehyde or glutaraldehyde, etc., and the residual cross-linking agents will affect the wound. Causes irritation and is not conducive to wound healing
Powdered minerals have good hemostasis and water absorption properties, and are also commonly used components in the preparation of composite hemostatic materials. However, powders are easy to aggregate and cause a decrease in hemostatic effect, and there is also a risk of powder falling off into blood vessels and causing vascular embolism. Powder can be immobilized Making it play the role of hemostasis and coagulation while avoiding leakage is a difficult problem facing the research and development of composite hemostatic materials
In order to improve the fit and adhesion of the composite hemostatic material and avoid the leakage of powdered minerals, researchers usually use the method of increasing the viscosity of the material or improving the compactness of the material, which in turn causes the hemostatic material to be difficult to separate from the wound, causing serious damage when it is removed. Problems with secondary damage or deterioration of material comfort

Method used

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  • Degradable chitosan-based composite hemostatic film
  • Degradable chitosan-based composite hemostatic film
  • Degradable chitosan-based composite hemostatic film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A degradable chitosan-based composite hemostatic film, comprising a substrate layer and a functional layer; the substrate layer is polycarbonate fiber cloth; the functional layer is modified chitosan, polyethylene glycol 2000, gelatin, Xanthan gum, Ag / Fe 2 o 3 The composite hydrogel prepared by magnetic nanoparticles, wrought stamen, and oleic acid amide, the functional layer is combined with the substrate layer through polydopamine; the ratio of parts by weight of the raw materials for the preparation of the functional layer is: modified chitosan 150 parts, polyethylene glycol 2000 10 parts, gelatin 40 parts, xanthan gum 20 parts, Ag / Fe 2 o 3 14 parts of magnetic nanoparticles, 25 parts of wrought stamen, and 0.2 parts of oleic acid amide.

[0032] The preparation method of the modified chitosan is: dissolving the chitosan powder in 1wt% acetic acid to form a 1wt% chitosan-acetic acid solution, adding hexanal, stirring at room temperature for 12 hours, adjusting the...

Embodiment 2

[0040] A degradable chitosan-based composite hemostatic film, comprising a substrate layer and a functional layer; the substrate layer is polylactic acid fiber cloth; the functional layer is modified chitosan, polyethylene glycol 2000, gelatin, Xanthan gum, Ag / Fe 2 o 3 The composite hydrogel prepared by magnetic nanoparticles, wrought stamen, and oleic acid amide, the functional layer is combined with the substrate layer through polydopamine; the ratio of parts by weight of the raw materials for the preparation of the functional layer is: modified chitosan 120 parts, polyethylene glycol 2000 8 parts, gelatin 32 parts, xanthan gum 16 parts, Ag / Fe 2 o 3 10 parts of magnetic nanoparticles, 18 parts of wrought stamen, and 0.15 parts of oleic acid amide.

[0041] The preparation method of the modified chitosan is: dissolving the chitosan powder in 1wt% acetic acid to form a 1wt% chitosan-acetic acid solution, adding dodecanal, stirring at room temperature for 12 hours, adjusting...

Embodiment 3

[0049] A degradable chitosan-based composite hemostatic film, comprising a substrate layer and a functional layer; the substrate layer is polycaprolactone fiber cloth; the functional layer is modified chitosan, polyethylene glycol 2000, Gelatin, Xanthan Gum, Ag / Fe 2 o 3 The composite hydrogel prepared by magnetic nanoparticles, wrought stamen, and oleic acid amide, the functional layer is combined with the substrate layer through polydopamine; the ratio of parts by weight of the raw materials for the preparation of the functional layer is: modified chitosan 90 parts, polyethylene glycol 2000 6 parts, gelatin 24 parts, xanthan gum 12 parts, Ag / Fe 2 o 3 6 parts of magnetic nanoparticles, 12 parts of wrought stamen, and 0.1 part of oleic acid amide.

[0050] The preparation method of the modified chitosan is as follows: dissolving the chitosan powder in 1wt% acetic acid to form a 1wt% chitosan-acetic acid solution, adding octadecanal, stirring at room temperature for 12 hours,...

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Abstract

The invention discloses a degradable chitosan-based composite hemostatic film which comprises a base material layer and a functional layer, and is characterized in that the base material layer is degradable fiber cloth; the functional layer is composite hydrogel prepared from modified chitosan, polyethylene glycol 2000, gelatin, xanthan gum, Ag / Fe2O3 magnetic nanoparticles, forged ophicalcitum and oleamide, and the functional layer is combined with the base material layer through polydopamine. The degradable chitosan-based composite hemostatic film provided by the invention has the advantages of softness, air permeability, high safety, good mechanical properties, strong water absorption and retention capacity, capability of being tightly attached to a wound, easiness in stripping, hemostasis, good anti-infection effect and no side effect of vascular embolism.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a degradable chitosan-based composite hemostatic film. Background technique [0002] Studies have shown that chitosan can adhere to and aggregate red blood cells and platelets, activate the coagulation pathway through the activation of platelets, accelerate the synthesis of fibrin glue, stimulate vasoconstriction, and finally seal the wound. At the same time, chitosan also has certain antibacterial, pain relieving, promoting wound healing and reducing scar effects, and is an ideal hemostatic material. However, pure chitosan materials, including gels and fibers, tend to have weak mechanical strength. Therefore, the research and development of chitosan-based composite hemostatic materials with stable properties, safety and non-toxicity, and good mechanical strength has become a hot spot. In the prior art, in order to improve the mechanical strength of the material wh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/22A61L15/26A61L15/40A61L15/44A61L15/46C08B37/08
CPCA61L15/425A61L15/40A61L15/225A61L15/26A61L15/44A61L15/46C08B37/003A61L2300/236A61L2300/608A61L2300/404A61L2300/418A61L2300/102A61L2400/04A61L2300/624C08L5/08C08L71/02C08L89/00C08L79/04
Inventor 张正男段书霞潘红福闫钧付迎坤常聪周静储旭何孜翰柳小军田林奇林建香郭文远
Owner HENAN YADU IND
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