Degradable chitosan-based composite hemostatic film

Abstract

The invention discloses a degradable chitosan-based composite hemostatic film which comprises a base material layer and a functional layer, and is characterized in that the base material layer is degradable fiber cloth; the functional layer is composite hydrogel prepared from modified chitosan, polyethylene glycol 2000, gelatin, xanthan gum, Ag / Fe2O3 magnetic nanoparticles, forged ophicalcitum and oleamide, and the functional layer is combined with the base material layer through polydopamine. The degradable chitosan-based composite hemostatic film provided by the invention has the advantages of softness, air permeability, high safety, good mechanical properties, strong water absorption and retention capacity, capability of being tightly attached to a wound, easiness in stripping, hemostasis, good anti-infection effect and no side effect of vascular embolism.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a degradable chitosan-based composite hemostatic film. Background technique [0002] Studies have shown that chitosan can adhere to and aggregate red blood cells and platelets, activate the coagulation pathway through the activation of platelets, accelerate the synthesis of fibrin glue, stimulate vasoconstriction, and finally seal the wound. At the same time, chitosan also has certain antibacterial, pain relieving, promoting wound healing and reducing scar effects, and is an ideal hemostatic material. However, pure chitosan materials, including gels and fibers, tend to have weak mechanical strength. Therefore, the research and development of chitosan-based composite hemostatic materials with stable properties, safety and non-toxicity, and good mechanical strength has become a hot spot. In the prior art, in order to improve the mechanical strength of the material wh...

AI Technical Summary

Problems solved by technology

In the prior art, in order to improve the mechanical strength of the material when preparing chitosan composite materials, most of them need to use cross-linking agents, such as terephthalaldehyde, adipaldehyde or glutaraldehyde, etc., and the residual cross-linking agents will affect the wound. Causes irritation and is not conducive to wound healing

Powdered minerals have good hemostasis and water absorption properties, and are also commonly used components in the preparation of composite hemostatic materials. However, powders are easy to aggregate and cause a decrease in hemostatic effect, and there is also a risk of powder falling off into blood vessels and causing vascular embolism. Powder can be immobilized Making it play the role of hemostasis and coagulation while avoiding leakage is a difficult problem facing the research and development of composite hemostatic materials

In order to improve the fit and adhesion of the composite hemostatic material and avoid the leakage of powdered minerals, researchers usually use the method of increasing the viscosity of the material or improving the compactness of the material, which in turn causes the hemostatic material to be difficult to separate from the wound, causing serious damage when it is removed. Problems with secondary damage or deterioration of material comfort

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