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Traditional Chinese medicine effective chemical component composition for treating primary dysmenorrhea and application thereof

A primary dysmenorrhea, chemical composition technology, applied in the direction of medical preparations containing active ingredients, drug combinations, organic active ingredients, etc., can solve problems such as interference with hormone levels in the body, adverse reactions in the central system, etc. No drug resistance phenomenon, the effect of simple preparation method

Pending Publication Date: 2021-05-07
CHINA PHARM UNIV
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, non-steroidal anti-inflammatory drugs and oral contraceptives are the first-line and second-line drugs for the clinical treatment of primary dysmenorrhea, and the effect is obvious, but the disadvantage is that non-steroidal anti-inflammatory drugs are likely to cause adverse reactions in the central system and gastrointestinal tract. Oral contraceptives can interfere with hormone levels in the body

Method used

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  • Traditional Chinese medicine effective chemical component composition for treating primary dysmenorrhea and application thereof
  • Traditional Chinese medicine effective chemical component composition for treating primary dysmenorrhea and application thereof
  • Traditional Chinese medicine effective chemical component composition for treating primary dysmenorrhea and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0032] Embodiment: 1. Detection of blood components of Gegen Decoction:

[0033] Experimental method: Wistar rats were randomly divided into a blank group, a low-dose administration group, and a high-dose administration group, with 4 rats in each group; fasting for 12 hours (free drinking water) before administration, and a low dose of 10g kg -1 , high dose 40g·kg -1 The amount of the crude drug was given to rats by intragastric administration; the blank group was given distilled water, and the treatment group was given low and high concentrations of Gegen decoction extract; 0.5mL of blood was collected from the orbits at 0.5h and 24h after administration, respectively, on pre-coated 1% Centrifuge for 10 min (3500r·min-1) in an EP tube of heparin sodium saline, and take the supernatant to obtain a plasma sample; freeze and store at -70°C.

[0034] After the plasma samples were treated with acetonitrile protein precipitation method, HPLC-DAD-TOF / MS technology was used to study...

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Abstract

The invention discloses a traditional Chinese medicine effective chemical component composition for treating primary dysmenorrhea and application thereof, and relates to the field of natural medicine components and medicine health care. Chemical components (puerarin, daidzin, daidzein, ephedrine, pseudoephedrine, paeoniflorin, albiflorin, liquiritin and liquiritigenin) in traditional Chinese medicine compound radix puerariae decoction are screened by virtue of a modern analysis technology and network pharmacology analysis; based on the hypothesis that effect substances contained in traditional Chinese medicines should enter blood or reach target organs to achieve the treatment effect, the blood-entering components of the radix puerariae decoction are detected by applying the modern analysis technology; furthermore, main active components and action targets are screened through network pharmacology; several or more compounds with the best combined drug effect are selected for composition; and the effects of definite components, definite drug effect, measurable mechanism and controllable quality are achieved.

Description

technical field [0001] The invention relates to the fields of natural medicine components and medical care, in particular to a composition of effective chemical components of traditional Chinese medicine for treating primary dysmenorrhea and its application. Background technique [0002] Primary dysmenorrhea (primary dysmenorrhea, PD) refers to a group of diseases without obvious pelvic organic lesions that cause cramping pain in the lower abdomen during menstruation, often accompanied by sweating, headache, nausea, vomiting, diarrhea, tremor, fatigue, etc. For other symptoms, syncope may occur in severe cases and require emergency medical treatment. It is a major public health problem that affects the normal study, work, social interaction and physical and mental health of adolescent and childbearing women. According to statistics, about 1 / 3 to 1 / 2 of women with dysmenorrhea will be absent from school or work at least once in each menstrual cycle, and 7.7% to 57.8% of adole...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K31/7048A61K31/137A61K31/704A61P15/00A61P29/00
CPCA61K31/352A61K31/7048A61K31/137A61K31/704A61P15/00A61P29/00
Inventor 余伯阳柴程芝闫艳
Owner CHINA PHARM UNIV
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