Preparation method of calcium gluconate suitable for industrial production

Abstract

The invention belongs to the technical field of calcium gluconate preparation, and particularly relates to a preparation method of calcium gluconate suitable for industrial production, which comprises the following steps of: (1) adding glucose and distilled water into a reaction container, then adding a catalytic amount of Tempo and a phase transfer catalyst, heating in a water bath environment at 40-50 DEG C, and continuously stirring; (2) gradually dropwise adding a sodium chlorate aqueous solution in a stirring state, and reacting for 4-5 hours; (3) continuing to dropwise add a calcium hydroxide aqueous solution in a stirring state, and reacting for 1-2 hours; (4) heating to 80-90 DEG C in a water bath, continuing to add a flocculant polyacrylamide, and reacting for 1-2 hours; and (5) concentrating to 1 / 3-1 / 2 of the original volume, finally adding H2O2, uniformly stirring, standing for 8-12 hours, and performing filtering and drying to obtain the white calcium gluconate. The preparation process is simple, the method is suitable for industrial production, and the yield is high.

Description

[0001] Technical field Suitable for industrial production [0002] The invention belongs to the technical field of calcium gluconate preparation, in particular to a preparation method of calcium gluconate suitable for industrial production. Background technique [0003] The production methods of calcium gluconate raw materials mainly include three methods: electrolytic oxidation, catalytic oxidation and fermentation. At present, most domestic manufacturers adopt the fermentation method, but there are still problems such as the cultivation and separation of black mold and the difficulty in controlling the by-products; electrolysis The oxidation method has disadvantages such as large investment, high cost, high energy consumption, and long cycle; catalytic oxidation is a relatively new chemical synthesis method at present, but the catalytic oxidation method requires expensive precious metal reagents, and the cost is not easy to control. In addition, the laboratory generally uses...

AI Technical Summary

Problems solved by technology

[0003] The production methods of calcium gluconate raw materials mainly include three methods: electrolytic oxidation, catalytic oxidation and fermentation. At present, most domestic manufacturers adopt the fermentation method, but there are still problems such as the cultivation and separation of black mold and the difficulty in controlling the by-products; electrolysis The oxidation method has disadvantages such as large investment, high cost, high energy consumption, and long cycle; catalytic oxidation is a relatively new chemical synthesis method at present, but the catalytic oxidation method requires expensive precious metal reagents, and the cost is not easy to control

In addition, the laboratory generally uses hydrogen peroxide or bromine water to oxidize glucose into gluconic acid, and calcium gluconate can be obtained after adding calcium carbonate for neutralization, but the synthesis yield of this method remains unchanged and low