Whitening skin care product and preparation method thereof
A whitening and hyaluronic technology, applied in the field of skin care products, can solve the problems that do not involve the absorption and carcinogenicity of kojic acid derivatives
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Embodiment 1
[0027] Synthesis of 2,4,6-trihydroxybenzoic acid-hyaluronic acid kojate-ester.
[0028] The synthesis method is as follows:
[0029] (1) Synthesis of hyaluronic acid kojate
[0030] Using kojic acid and hyaluronic acid as raw materials, carry out esterification reaction to obtain hyaluronic acid kojic acid ester;
[0031] Dissolving hyaluronic acid in water and stirring to obtain a hyaluronic acid solution with a mass volume concentration of 50 g / L, dissolving kojic acid in water and stirring to obtain a kojic acid solution with a mass volume concentration of 50 g / L; the hyaluronic acid solution and The kojic acid solution was mixed according to the volume ratio of 1:1.3, and the cation exchange resin-ferric chloride complex was used as a catalyst to perform an esterification reaction in a water bath environment at 42°C to obtain hyaluronic acid kojic acid ester. The structural formula of hyaluronic acid kojic acid ester is shown in formula (I):
[0032]
[0033] (2) Syn...
Embodiment 2
[0045] The 2,4,6-trihydroxybenzoic acid-hyaluronic acid kojic acid ester-ester prepared in Example 1 was applied to whitening skin care products, and corresponding mask and cream products were prepared respectively. See Table 2 and Table 3 for the ingredients and content of facial mask and cream products. In order to evaluate the efficacy of the prepared whitening skin care product, volunteers are selected to try out the product, and then the efficacy of the product is evaluated. Among them, the number of volunteers is 120, aged 25-30, divided into 4 groups, and evaluated after using the product continuously for one month. Evaluation indicators include: whitening effect, repairing effect, moisturizing effect. The score ranges from 1 to 10, with 1 being the worst and 10 being the best. See Table 2 and Table 3 for the evaluation results.
[0046] Table 2
[0047] whitening skin care mask Control group 1 2,4,6-Trihydroxybenzoic acid-hyaluronic acid kojate-es...
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