Application of arctiin and arctigenin in preparation of medicine for treating and/or preventing skin inflammations

A technology of arctigenin and arctiside, which is applied in the directions of skin diseases, drug combinations, and pharmaceutical formulations, can solve problems such as studies that have not yet been reported, and achieves increased system stability, improved stability, enhanced skin permeability and lingering effect

Inactive Publication Date: 2021-05-21
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Arctiin and aglycon in burdock fruit are its main active ingredients. At present, many studies have shown that arctiin or aglycon has certain curative effects in antibacterial, antiviral, and treatment of obesity, diabetes, inflammatory diseases and cancer. However, no one has reported on arctiin and arctigenin in the treatment of psoriasis, atopic dermatitis, etc.

Method used

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  • Application of arctiin and arctigenin in preparation of medicine for treating and/or preventing skin inflammations
  • Application of arctiin and arctigenin in preparation of medicine for treating and/or preventing skin inflammations
  • Application of arctiin and arctigenin in preparation of medicine for treating and/or preventing skin inflammations

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0113] The preparation of embodiment 1 arctiin or arctigenin ointment

[0114] A. Preparation of Ointment Base

[0115] 1) 15 parts of liquid paraffin, 50 parts of vaseline, 50 parts of glyceryl monostearate, and 100 parts of monostearic acid were mixed and heated to 70°C to obtain oil phase A;

[0116] 2) Dissolve 100 parts of glycerin, 2 parts of triethanolamine, 2 parts of sodium lauryl sulfate, and 1 part of ethylparaben in 450 parts of purified water, and heat to 70°C to obtain aqueous phase B;

[0117] 3) Slowly add the oil phase A into the water phase B, and keep stirring to make an ointment base, let stand, and cool.

[0118] B. Preparation of arctiin or arctigenin ointment

[0119] 1) 15 parts of liquid paraffin, 50 parts of vaseline, 50 parts of glyceryl monostearate, and 100 parts of monostearic acid were mixed and heated to 70°C to obtain oil phase A;

[0120] 2) Dissolve 100 parts of glycerin, 2 parts of triethanolamine, 2 parts of sodium lauryl sulfate, and 1 ...

Embodiment 2

[0123] The preparation of embodiment 2 arctiin or arctigenin ointment

[0124] 1) 15 parts of liquid paraffin, 50 parts of vaseline, 50 parts of glyceryl monostearate, and 100 parts of monostearic acid were mixed and heated to 70°C to obtain oil phase A;

[0125] 2) Dissolve 100 parts of glycerin, 2 parts of triethanolamine, 2 parts of sodium lauryl sulfate, and 1 part of ethyl paraben in 450 parts of purified water, heat to 70°C, and add 15 parts of arctiin or arctigenin , to obtain water phase B; stir rapidly to dissolve; slowly add oil phase A to water phase B, and keep stirring to make arctiin or arctigenin ointment, let stand, and cool.

[0126] The specifications of the ointment can be selected according to the actual needs, usually unit formulations, 20g, 30g, 40g and other specifications. In this embodiment, the concentration of arctiin or arctigenin ointment preparation is 2% (wt).

Embodiment 3

[0127] The preparation of embodiment 3 arctiin or arctiin emulsion

[0128] An arctigenin emulsion comprising:

[0129] Arctigenin 5g, 244FP 1.5g, diethylene glycol monoethyl ether 11.5g, hydroxypropyl cellulose 2g, light liquid paraffin 25g, water 60g.

[0130] The preparation method of above-mentioned external preparation comprises the steps:

[0131] Dissolving arctigenin in the prescription amount in diethylene glycol monoethyl ether, adding water and hydroxypropyl cellulose, fully swelling, and obtaining the water phase; Disperse 244FP in light liquid paraffin to obtain an oil phase; add the oil phase to the water phase and homogenize at a speed of 15,000 rpm for 5 minutes to obtain the product.

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Abstract

The embodiment of the invention relates to novel application of arctiin and arctigenin, in particular to application of arctiin and arctigenin in preparation of a medicine for treating and/or preventing skin inflammations. More specifically, the invention relates to application of arctiin and/or arctigenin and/or an analogue of one of the arctiin and the arctigenin in preparation of the medicine for treating and/or preventing psoriasis, atopic dermatitis and other skin inflammations. The embodiment of the invention discloses the application of the arctiin and/or the arctigenin and/or the analogue of one of the arctiin and the arctigenin in preparation of the medicine for treating and/or preventing the skin inflammations for the first time. It is proved that the arctiin and the arctigenin have good treatment effects on skin inflammations such as psoriasis and atopic dermatitis, and have good clinical application prospects. Besides, it is found that through a local administration mode, the curative effect and convenience of the arctiin or arctigenin for treating the psoriasis and the atopic dermatitis can be improved, and adverse reactions are reduced.

Description

technical field [0001] The present invention relates to new uses of arctiin and arctigenin, in particular to the application of arctiin and arctigenin in the preparation of medicines for treating and / or preventing skin inflammation, more specifically to arctiin and arctiin Use of the element in the preparation of medicines for treating and / or preventing skin inflammations such as psoriasis and atopic dermatitis. Background technique [0002] Psoriasis is a common chronic relapsing inflammatory skin disease. The typical clinical manifestations are erythema, rash, plaque, and scales with clear boundaries. The pathogenesis of the disease is complex and the etiology is unknown. At present, the treatment of psoriasis is mainly based on local treatment. Steroid hormones such as hydrocortisone butyrate and mometasone furoate are widely used in the treatment of psoriasis, but long-term use has large side effects, which affects its wide application; Limus, carbotriol, etc. also limi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/365A61P17/00A61P17/06A61P17/04
CPCA61K31/7048A61K31/365A61P17/00A61P17/06A61P17/04A61K2300/00
Inventor 许叶春唐炜张向磊李恒范晨
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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