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Preparation method of cannabidiol powder, prepared cannabidiol powder and application thereof

A technology of cannabidiol and cannabidiol oil, which is applied in the directions of powder delivery, preparations for skin care, and medical preparations of inactive ingredients, etc. The effect of application efficiency

Pending Publication Date: 2021-06-04
CHENGUANG BIOTECH GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the technical problems still existing in the above-mentioned prior art, the inventors found that by using the method for preparing cannabidiol powder described in this application, by adding emulsifier in the described way, combined with adding biological Acceptable carrier or excipient can obtain cannabidiol powder with specific combination form and microstructure, solve the problem that cannabidiol is insoluble in water, and make it have good dispersion performance in water, and the obtained water dispersion system Achieve good uniform stability; and the resulting cannabidiol powder product has good stability and is convenient for storage and use

Method used

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  • Preparation method of cannabidiol powder, prepared cannabidiol powder and application thereof
  • Preparation method of cannabidiol powder, prepared cannabidiol powder and application thereof
  • Preparation method of cannabidiol powder, prepared cannabidiol powder and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] (1) Accurately weigh 10g of full-spectrum oil (cannabidiol content: 50wt%), weigh 5g of poloxamer 188, add it, and melt it in a water bath at 70°C.

[0056] (2) Weigh 65g of hydroxypropyl β-cyclodextrin and dissolve it in 1000mL of 95% ethanol until it is completely dissolved.

[0057] (3) Mix the solution prepared in (1) with the solution prepared in (2), and react in a water bath at 40°C for 3 hours;

[0058] (4) The reaction solution is dried under reduced pressure to obtain an inclusion compound of cannabidiol, which can be pulverized to obtain a powder, and the content of cannabidiol is detected to be 6.05%.

Embodiment 2

[0061] (1) Accurately weigh 10 g of cannabidiol oil (CBD content 83wt%, THC not detected), add 10 mL of 95% ethanol to dissolve completely;

[0062] (2) Dissolve 5g of sucrose fatty acid ester and 1g of phospholipid in the solution described in (1), and dissolve evenly;

[0063] (3) Weigh 64g of modified starch into a 500mL beaker, add 200mL of pure water, and heat evenly in a 60°C water bath until it dissolves completely.

[0064] (4) Add the solution prepared in (2) into (3), and shear emulsify.

[0065] (5) Spray-dry the uniformly emulsified emulsion to obtain powder, and detect that the content of cannabidiol is 10.01%. Comparative example 2: In the above-mentioned embodiment, step (2) is removed, and 70 g of modified starch is directly added to (3), The rest of the steps are the same, and the powder is obtained, and the detected cannabidiol content is 10.03%.

Embodiment 3

[0067] (1) Accurately weigh 10g of cannabidiol oil (CBD content 80wt%), and use 100mL of absolute ethanol to dissolve it ultrasonically.

[0068] (2) Weigh 50 g of hydroxypropyl β-cyclodextrin, dissolve it in the solution in (1), and sonicate until it is completely dissolved.

[0069] (3) Dry the solution prepared in (2) under reduced pressure to obtain clathrate, and pulverize to obtain powder.

[0070] (4) Dissolve the prepared powder in 210 mL of purified water, react in a water bath at 70°C for 10 min, add 30 g of sucrose ester, dissolve completely, and shear emulsify.

[0071] (5) The emulsified aqueous solution is spray-dried to obtain a powder, and the detected cannabidiol content is 8.62%.

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Abstract

The invention provides a preparation method of cannabidiol powder. The cannabidiol powder is prepared from cannabidiol oil, an emulsifier and a biologically acceptable carrier or excipient; the emulsifier and the biologically acceptable carrier or excipient are compounded in a certain way to obtain the cannabidiol powder with a specific combination form and a microstructure; the problem that cannabidiol is insoluble in water is solved, the dispersion performance of the cannabidiol in water is good, and an obtained aqueous dispersion system achieves high uniform stability; and the obtained cannabidiol powder product has high stability and is convenient to store and use.

Description

technical field [0001] The invention belongs to the field of preparation preparation and application, and relates to a method for preparing cannabidiol powder with improved water solubility, the cannabidiol powder prepared by the method and its application. Background technique [0002] Cannabidiol is a natural active ingredient from the stems, leaves, and seeds of the annual herb Cannabis genus Cannabis, which has a variety of pharmacological activities and is effective in epilepsy, inflammation, Alzheimer's disease, and multiple sclerosis (MS). , Parkinson's disease, amyotrophic lateral sclerosis and other neurodegenerative diseases have therapeutic effects, in addition, it has therapeutic and alleviating effects on mental diseases such as schizophrenia, depression, anxiety, etc. In addition, it has significant analgesic effects Advantage. The numerous pharmacological effects of cannabidiol can be used in many aspects such as medicine, food, skin care products, health car...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K9/10A61K31/05A61K47/10A61K47/40A61K47/26A61K47/24A61K47/36A61K47/69A61P25/08A61P29/00A61P25/28A61P25/00A61P37/02A61P25/16A61P25/18A61P25/24A61P25/22A61K8/34A61K8/86A61K8/73A61K8/60A61K8/55A61Q19/10A61Q19/00A61Q17/04A23L33/105A23L29/10A23L2/52
CPCA61K9/14A61K9/10A61K31/05A61K47/10A61K47/40A61K47/26A61K47/24A61K47/36A61K47/6951A61P25/08A61P29/00A61P25/28A61P25/00A61P37/02A61P25/16A61P25/18A61P25/24A61P25/22A61K8/347A61K8/86A61K8/738A61K8/60A61K8/553A61K8/732A61K8/73A61Q19/10A61Q19/00A61Q17/04A23L33/105A23L29/10A23L2/52A23V2002/00A23V2200/222A23V2250/21A23V2250/2132A23V2250/18
Inventor 高伟焦丽娟徐建中任婷婷
Owner CHENGUANG BIOTECH GRP CO LTD
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