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Antibacterial application of purple phosphorus and its two-dimensional nanosheets

A two-dimensional nanometer and antibacterial agent technology, which is applied in the direction of antibacterial drugs, medical preparations containing active ingredients, active ingredients of phosphorus compounds, etc., can solve the problem of no antibacterial research and achieve excellent antibacterial performance, high antibacterial activity, The effect of accelerating wound healing

Active Publication Date: 2022-02-01
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, at present, there is no research on the antibacterial aspects of purple phosphorus and purple phosphorene

Method used

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  • Antibacterial application of purple phosphorus and its two-dimensional nanosheets
  • Antibacterial application of purple phosphorus and its two-dimensional nanosheets
  • Antibacterial application of purple phosphorus and its two-dimensional nanosheets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] An antibacterial application of a novel two-dimensional material purple phosphorus nanosheet, comprising the following steps:

[0028] Step 1: Put 100mg bulk purple phosphorus (VP) and 180mL ethanol solvent into a 250mL round bottom flask together;

[0029] Step 2: Put the above-mentioned round-bottomed flask into an ultrasonic cleaning machine, ultrasonically treat it for 2 hours under the condition of 500W, and then put it into a cell pulverizer under the condition of ice bath, 25KHz, 650W, and ultrasonicate for 10h to obtain Dispersions;

[0030] Step 3: Centrifuge the dispersion obtained above by a two-step method: first centrifuge the dispersion at 1000rpm for 20min, and then centrifuge the separated supernatant at 15000rpm for 30mim to obtain two kinds of 1-9nm and larger than 9nm Purple phosphorus nanosheets with different thicknesses;

[0031] Step 4: Wash the above-mentioned purple phosphorus nanosheets with different thicknesses 3-4 times with deionized wate...

Embodiment 2

[0039] The difference from the parameter conditions in Example 1 is that neither purple phosphorus nor black phosphorus solids are subjected to liquid stripping treatment, and after simple grinding, the antibacterial effect on Escherichia coli is tested. Other conditional parameters are with embodiment 1.

[0040] The test results are as follows:

[0041] The antibacterial effects of black phosphorus and purple phosphorus are as follows: figure 2 As shown, it can be seen from the figure that the survival rate of E. coli after treatment with blocky purple phosphorus is far lower than that of blocky black phosphorus, which proves that the antibacterial effect of purple phosphorus is better.

Embodiment 3

[0043] The difference from the parameter conditions of Example 1 is that the antibacterial test is performed under dark and natural light conditions, and other condition parameters are the same as in Example 1.

[0044] The test results are as follows: the antibacterial rate of purple phosphorus two-dimensional nanosheets under dark and natural light conditions is less than that under LED lights, such as Figure 5 shown.

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Abstract

The invention discloses the antibacterial application of purple phosphorus and two-dimensional nanosheets based on it, and belongs to the technical field of biomedicine preparation. The present invention reveals for the first time that purple phosphorus block and purple phosphorus nanosheets have excellent antibacterial properties, without modification, the pure purple phosphorus raw material has excellent antibacterial properties, can be well applied to the preparation of antibacterial agents, and has no antibiotic resistance sex issue. The present invention proves through bacterial experiments that purple phosphorus has higher antibacterial activity than black phosphorus after a series of antibacterial tests are carried out against two common pathogens (ie, Escherichia coli and Staphylococcus aureus).

Description

technical field [0001] The invention belongs to the technical field of biomedicine preparation and relates to a bactericidal reagent, in particular to the antibacterial application of purple phosphorus and two-dimensional nanosheets based thereon. Background technique [0002] With the global spread of antibiotic resistance, finding new antibiotics that can avoid antibiotic resistance poses unprecedented challenges to antimicrobial research. In recent years, the research on non-antibiotic antibacterial substances has become a hot spot and development direction of scientific research. Antimicrobial nanomaterials are considered as a promising material as a strategy to overcome the problem of bacterial resistance. [0003] Two-dimensional phosphorus (eg, black phosphorus) is an antimicrobial agent that has attracted increasing interest in antimicrobial-related fields due to its high pathogen elimination efficiency, biosafety, and on-demand degradability. However, black phosph...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/42A61K41/00A61P31/04A61P17/02
CPCA61K33/42A61K41/00A61P31/04A61P17/02A61K2300/00Y02A50/30
Inventor 张锦英董阿力德尔图张丽辉沈秋狄
Owner XI AN JIAOTONG UNIV
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