Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method of hernia patch with antibacterial effect

An antibacterial effect and hernia technology, which is applied in the field of medical devices, can solve the problems of easy shedding, coating or electrospun membrane and hernia patch are not so tightly bonded, and the antibacterial effect is poor in durability, so that it is not easy to fall off and long-term release Effect, long-acting antibacterial effect

Active Publication Date: 2021-06-04
HENAN AGRICULTURAL UNIVERSITY
View PDF5 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In view of the above situation, in order to solve the defects of the prior art, the purpose of the present invention is to provide a method for preparing a hernia patch with antibacterial effect, which can effectively solve the problem of the existing coating or electrospun membrane and the hernia patch. The combination is not so tight, and it is often easy to fall off; on the other hand, the antibacterial effect is relatively poor in durability

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of hernia patch with antibacterial effect
  • Preparation method of hernia patch with antibacterial effect
  • Preparation method of hernia patch with antibacterial effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] When the present invention is implemented, the preparation method of the PLA electrospinning hollow tube containing filler comprises the following steps:

[0021] 1) Preparation of electrospinning hollow tube:

[0022] Taking the 5mL electrospinning liquid system as an example, accurately measure 2.5mL of N,N dimethylformamide, 1.67mL of chloroform, and 0.83mL of acetone in a graduated cylinder, weigh 0.5g of PLA material with an electronic balance, and then pour the weighed PLA into Put it into the mixed chloroform / acetone / N,N dimethylformamide solution, oscillate and stir for 1.5h until the PLA is completely dissolved to obtain the spinning solution, and then put the spinning solution on the electrospinning machine. The spraying conditions are: voltage 20kV, receiving distance 7cm, the advancing rate of the syringe is 0.5mL / h, the ambient temperature is 23°C, the humidity is 60%, and a drum with a diameter of 5mm is used for receiving; the preparation mass concentrati...

Embodiment 2

[0028] When the present invention is concretely implemented, the preparation method of the PLGA electrospinning hollow tube containing filler comprises the following steps:

[0029] 1) Preparation of electrospinning hollow tube:

[0030] Taking the 10mL electrospinning liquid system as an example, accurately measure 5mL of N,N dimethylformamide, 3.33mL of chloroform, and 1.67mL of acetone in a measuring cylinder, weigh 1g of PLGA material with an electronic balance, and then pour the weighed PLGA into the mixing In a good chloroform / acetone / N,N dimethylformamide solution, shake and stir for 1.5h until the PLGA is completely dissolved to obtain a spinning solution, and then put the spinning solution on the electrospinning machine. Be: voltage 25kV, receiving distance 10cm, the advancing rate of syringe is 0.5mL / h, ambient temperature is 25 ℃, humidity is 65%, adopts the roller that diameter is 5mm to receive; Preparation mass concentration is 0.35% norfloxacin Solution, stop e...

Embodiment 3

[0036] When the present invention is implemented, the preparation method of the PLA electrospinning hollow tube containing filler comprises the following steps:

[0037] 1) Preparation of electrospinning hollow tube:

[0038]Taking the 15mL electrospinning liquid system as an example, accurately measure 7.5mL of N,N dimethylformamide, 5mL of chloroform, and 2.5mL of acetone in a graduated cylinder, weigh 1.8g of PLA material with an electronic balance, and then pour the weighed PLA into In the mixed chloroform / acetone / N,N dimethylformamide solution, shake and stir for 1.5h until the PLA is completely dissolved to obtain a spinning solution, and then put the spinning solution on the electrospinning machine, and the electrospinning machine is electro-sprayed The conditions are: the voltage is 30kV, the receiving distance is 12cm, the advancing rate of the syringe is 0.5mL / h, the ambient temperature is 27°C, the humidity is 70%, and a roller with a diameter of 5mm is used for rec...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a preparation method of a hernia patch with an antibacterial effect, which can effectively solve the problems that the existing coating or electrostatic spinning membrane is not tightly combined with the hernia patch and is easy to fall off; and on the other hand, the persistence of antibacterial effect is poor. The technical scheme is that, the hernia patch with the antibacterial effect provided by the invention is prepared through the following steps: 1) a hollow electrostatic spinning hollow tube with the antibacterial effect is obtained through an electrostatic spinning method; 2) cutting up an electrostatic spinning membrane with the antibacterial effect which is obtained by an electrostatic spinning method, and placing the cut electrostatic spinning membrane as a filler into the electrostatic spinning hollow tube; 3) holes with proper sizes and depths are formed in a common hernia patch; 4) the hollow tube containing the filler and a common hernia patch are compounded. According to the invention, the hollow tube containing the filler is fixed to the surface of the hernia patch in an embedded mode, so that the hollow tube containing the filler is not prone to falling off and has a long-acting antibacterial effect. The hernia patch with antibacterial effect provided by the invention is an innovation of the hernia patch.

Description

technical field [0001] The invention relates to a medical device, in particular to a method for preparing a hernia patch with antibacterial effect. Background technique [0002] At present, the process of clinically implanting hernia mesh is prone to infection due to various factors. At present, hernia mesh is made of polymer materials, which often do not have antibacterial function. Cause infection, antibacterial effect is particularly important, the traditional coating method or the hernia patch modified by functional electrospun membrane, on the one hand, the combination of coating or electrospun membrane and hernia patch It is not so tight and tends to fall off easily; on the other hand, the antibacterial effect is less durable. Therefore, the improvement and innovation of hernia mesh is an urgent problem to be solved at present. Contents of the invention [0003] In view of the above situation, in order to solve the defects of the prior art, the purpose of the prese...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/54A61L27/18D01D5/00D04H1/728D01F6/62D01F6/84D01F11/08
CPCA61L27/54A61L27/18D01D5/0015D04H1/728D01F6/62D01F6/84D01F11/08A61L2400/18A61L2300/204A61L2300/602A61L2300/404C08L67/04
Inventor 马振玲杨军政刘薇
Owner HENAN AGRICULTURAL UNIVERSITY