A kind of bacterial cellulose membrane and breast patch and preparation method thereof

A technology of bacterial cellulose membrane and patch, which is applied in the field of medical biomaterials, can solve the problem that cells cannot grow ideally on it, and achieve the goal of helping breast repair, improving the safety of clinical use, and enhancing clinical compliance Effect

Active Publication Date: 2022-07-01
NKD PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The existing bacterial cellulose membrane, as a biofilm with good mechanical properties, has no immunogenicity in the process of being applied to the human body, but when it is applied to the breast patch, the cells cannot grow ideally on it, so it is urgently needed A bacterial cellulose membrane that can be used as a breast patch, and use it as a base material to develop breast patches with better performance to meet clinical needs

Method used

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  • A kind of bacterial cellulose membrane and breast patch and preparation method thereof
  • A kind of bacterial cellulose membrane and breast patch and preparation method thereof
  • A kind of bacterial cellulose membrane and breast patch and preparation method thereof

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preparation example Construction

[0037] In view of the problems existing in breast patches in the prior art, the present invention first provides a bacterial cellulose film for preparing breast patches, and the preparation method of the bacterial cellulose film includes the following steps: preparing bacterial fibers by rotary fermentation In the process of fermentation, macromolecular substances with a particle size of 10-500 μm are sprayed onto the bacterial cellulose film, so that the macromolecular substances are distributed in the bacterial cellulose film.

[0038] The bacterial cellulose membrane has good compatibility with the human body, but the pore size of the surface of the bacterial cellulose membrane prepared by the existing method is usually micron, and cells cannot ideally grow on its surface. The addition of the above substances in the process of the plain film is conducive to the formation of certain gaps between the bacterial cellulose films of different layers, which is conducive to the grow...

Embodiment 1

[0068] The present embodiment relates to a method for preparing a breast patch, comprising the following steps:

[0069] 1) To the rotary fermenter (its schematic diagram is as figure 1 ) in the tank body 1, add a fermentation medium, to its height and the surface of the bacterial cellulose film formation frame 2; , yeast extract 2.5g, citric acid 0.5g, disodium hydrogen phosphate 1g, dipotassium hydrogen phosphate 0.5g and the balance of distilled water;

[0070] 2) by activating the Acetobacter xylinum producing cellulose film to obtain an activated bacterial classification, the activated bacterial classification is expanded and cultivated to obtain a seed liquid, the seed liquid is inoculated into a fermentation medium and fermented to obtain a bacterial cellulose fermentation liquid, which is fermented for 5 days. Then, a bacterial cellulose film is formed on the surface of the bacterial cellulose forming frame;

[0071] 3) Rotate the rotating shaft, make the bacterial c...

Embodiment 2

[0083] The present embodiment relates to a method for preparing a breast patch, comprising the following steps:

[0084] 1) To the rotary fermenter (its schematic diagram is as figure 1 ), add the fermentation medium to its height and the surface of the bacterial cellulose membrane to form the frame; the formula of the fermentation medium is to contain in every 500mL: glucose 20g, maltose 15g, peptone 2.5g, yeast extract 2.5g , citric acid 0.5g, disodium hydrogen phosphate 1g, dipotassium hydrogen phosphate 0.5g and the balance of distilled water;

[0085] 2) activating the Acetobacter xylinum producing cellulose film, obtaining activated bacterial classification, expanding the activated bacterial classification to obtain seed liquid, inoculating the seed liquid into the fermentation medium and fermenting to obtain bacterial cellulose fermentation liquid, fermenting through 6 days Then, a bacterial cellulose film is formed on the surface of the bacterial cellulose forming fra...

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Abstract

The invention belongs to the technical field of medical biological materials, and in particular relates to a bacterial cellulose membrane, a breast patch and a preparation method thereof. The preparation method of the bacterial cellulose membrane includes the following steps: preparing the bacterial cellulose membrane by rotary fermentation, and spraying macromolecular substances with a particle size of 10-500 μm on the bacterial cellulose membrane during the fermentation to make the bacterial cellulose membrane. Molecular species are distributed in the bacterial cellulose membrane. The breast patch prepared by using the bacterial cellulose membrane of the present invention has no immunogenicity, has good compatibility with the human body, has good mechanical properties, meets clinical suture strength requirements, and can well fix breast prostheses body and help with breast repair.

Description

technical field [0001] The invention belongs to the technical field of medical biological materials, and in particular relates to a bacterial cellulose membrane, a breast patch and a preparation method thereof. Background technique [0002] Breast cancer is the most common malignant tumor among women in the world, and nearly half of women choose to have their breasts removed during treatment. However, breast removal will bring enormous psychological pressure to the patient's normal life. Therefore, many people choose to have breast cancer. Repair and rebuild. In the process of breast reconstruction, due to the original defect, the implantation of the prosthesis may easily lead to the displacement of the prosthesis, which requires a biological patch for fixed repair and reduces related complications such as cysts. [0003] In response to this problem, breast patches on the market are currently divided into synthetic material patches and biological material patches. Syntheti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P19/04A61F2/00
CPCC12P19/04A61F2/0063A61F2/0059
Inventor 石凌锋张璋刘廷薇陶秀梅
Owner NKD PHARMA CO LTD
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