Preparation method of composite styptic powder

A technology of hemostatic powder and starch, which is applied in medical science, bandages, absorbent pads, etc., can solve the problems of uneven particle size distribution of hemostatic powder particles, affecting the particle size of microporous polysaccharides, affecting the hemostatic performance of materials, etc. Coagulation effect, the effect of promoting uniform porosity and improving hemostatic properties

Inactive Publication Date: 2015-11-18
SHAANXI BOYU REGENERATIVE MEDICINE CO LTD
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  • Summary
  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

The composite microporous polysaccharide hemostatic powder uses starch in combination with other absorbable hemostatic materials. Since carboxymethyl chitosan is a hydrophilic substance, the hydrophilic property of the material is increased. At the same time, chitosan itself can interact with blood cells. However, the hemostatic powder prepared by this method also has the problem of uneven particle size distribution, which affects the hemostatic performance of the material.
[0007] In the above-mentioned patents, the main process is to use starch or composite cross-linking modification with other hemostatic materials. Since the above-mentioned starch granules are usually prepared by emulsifying starch or its blends to form micropores, physical, chemical or Enzymatic hydrolysis cross-linking, the existing problem is that its structure is easily damaged in the process of preparing microporous starch or other microporous polysaccharides, and a good cross-linking effect cannot be achieved. diameter control
In addition, there are still potential safety hazards in the use of cross-linking agents in the preparation process of microporous polysaccharide hemostatic powder

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0028] The preparation method of a hemostatic powder provided by the present invention, the main process is: 1) starch cross-linking; 2) blending liquid preparation; 3) blending and emulsifying; 4) preparing hydrogel microspheres; 5) washing, dehydrating and drying; 6) Screening. Specific steps are as follows:

[0029] Step 1: Starch cross-linking: Take 10-100g of starch, add 100-1000ml deionized water, and preheat it in a water bath at 45-80°C for 10-30 minutes. The starches mainly include potato starch, corn starch, tapioca starch, and wheat starch , Sorghum starch and mung bean starch. At the same time, stir with an electric stirrer at a stirring speed of 500-5000 rpm, and then slowly add 0.1-1% (w / w) crosslinking agent to adjust the pH of the starch emulsion to 8-11, and react for 2 to 4 hours.

[0030] The crosslinking agent is one of sodium trimetaphosphate, polypropylene glycol, trimethylolpropane, calcium chloride, and acrylic acid.

[0031] In the cross-linked starch prep...

specific Embodiment approach

[0042] The present invention will be further described in detail below in conjunction with implementation cases, but the implementation of the present invention is not limited to this.

[0043] 1. Example

[0044] Step 1. Starch cross-linking: Weigh 10g of corn starch, add 100ml of deionized water, preheat in a 60℃ water bath for 20 minutes, while stirring with an electric stirrer, adjust the stirring rate to 1000rpm, and then slowly add 0.5% (w / w ), adjust the pH of the starch emulsion to 11, and react for 4 hours.

[0045] Step 2: Preparation of the blend solution: Weigh 1 g each of carboxymethyl chitosan and sodium carboxymethyl cellulose, and dissolve them in 100 ml of distilled water respectively to prepare an aqueous solution with a concentration of 1%. After mixing the above-prepared solutions, fully stir to prepare an aqueous solution.

[0046] Step 3: Blending and emulsification: Take the blended solution from Step 2 and add it to the cross-linked corn starch solution in Ste...

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PUM

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Abstract

The invention discloses a preparation method of composite styptic powder. The composite styptic powder is obtained by emulsifying and crosslinking carboxymethyl chitosan and sodium carboxymethylcellulose. Specifically, the preparation method comprises the steps of firstly crosslinking starch, then blending the crosslinked starch with carboxymethyl chitosan and sodium carboxymethylcellulose, emulsifying, and crosslinking again to obtain the composite styptic powder. The grain size of the composite styptic powder is 30-100 Mu m, the adsorption property is good, the surface is rippled, the safety is high, and the styptic property is good.

Description

Technical field [0001] The invention belongs to the field of biomedical materials, and specifically relates to a preparation method of a composite hemostatic powder. Background technique [0002] Intraoperative wound bleeding is a common surgical problem, which can lead to blood transfusion and related complications. Excessive intraoperative bleeding makes the operation time longer, and serious complications such as hemorrhagic shock and even death of the patient. Intraoperative bleeding not only causes difficulties for doctors, but also undue losses to patients. Therefore, the development of hemostatic materials has always been one of the focuses of attention in the fields of clinical medicine, biological materials and medical devices. [0003] At present, a variety of new locally absorbable hemostatic materials have been developed at home and abroad. Commonly used local hemostatic materials include traditional gelatin sponge, oxidized regenerated cellulose, fibrin glue, alginate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/42A61L15/44A61L15/64
Inventor 尹晓刚
Owner SHAANXI BOYU REGENERATIVE MEDICINE CO LTD
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