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A kind of arbidol hydrochloride injection emulsion and preparation method thereof

A technology of arbidol hydrochloride and emulsion, which is applied in the field of medicine and can solve the problems of poor stability and low solubility

Active Publication Date: 2022-07-12
SHIJIAZHUANG NO 4 PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the problems of low solubility and poor stability of arbidol hydrochloride injection, the invention provides a kind of arbidol hydrochloride injection emulsion, and also provides a preparation method of the injection emulsion

Method used

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  • A kind of arbidol hydrochloride injection emulsion and preparation method thereof
  • A kind of arbidol hydrochloride injection emulsion and preparation method thereof
  • A kind of arbidol hydrochloride injection emulsion and preparation method thereof

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Embodiment 1

[0038] The embodiment of the present invention provides a kind of arbidol hydrochloride injection emulsion, which is composed of the following components:

[0039] Arbidol hydrochloride 1.2g, soybean lecithin 3g, Tween 80 1g, gum arabic 1g, n-propanol 2g, soybean oil 80g, glucose 15g, vitamin C 2g, appropriate amount of citric acid, and water for injection were added to 1000mL;

[0040] The preparation method of above-mentioned Arbidol hydrochloride injection emulsion is as follows:

[0041] Weigh each component according to the above-mentioned proportion, add Arbidol hydrochloride, soybean lecithin, Tween 80, gum arabic, n-propanol into soybean oil, heat and stir to dissolve as oil phase; add glucose and vitamin C to the soybean oil In 200mL water for injection, heat and stir to dissolve as the water phase; add the oil phase to the water phase under shear and mix to make colostrum, shear speed 5000r / min, shear time 7min; add water for injection to 1000ml and use citron The p...

Embodiment 2

[0043] The embodiment of the present invention provides a kind of arbidol hydrochloride injection emulsion, which is composed of the following components:

[0044]Arbidol hydrochloride 4.8, soybean lecithin 15g, Tween 80 15g, gum arabic 15g, n-propanol 15g, soybean oil 300g, glycerin 45g, vitamin C 5g, acetic acid-sodium acetate buffer appropriate amount, and water for injection added to 1000mL;

[0045] The preparation method of above-mentioned Arbidol hydrochloride injection emulsion is as follows:

[0046] Weigh each component according to the above proportion, add Arbidol hydrochloride, soybean lecithin, Tween 80, gum arabic, n-propanol to soybean oil, heat and stir to dissolve as oil phase; add glycerin and vitamin C to In 500mL water for injection, heat and stir to dissolve as the water phase; add the oil phase to the water phase under shear and mix to make colostrum, the shear speed is 10000r / min, and the shear time is 20min; add water for injection to 1000ml and add a...

Embodiment 3

[0048] The embodiment of the present invention provides a kind of arbidol hydrochloride injection emulsion, which is composed of the following components:

[0049] Arbidol hydrochloride 3g, soybean lecithin 10g, Tween 80 5g, gum arabic 7g, n-propanol 7g, soybean oil 150g, glycerin 30g, vitamin C 3g, an appropriate amount of acetic acid-sodium acetate buffer, and water for injection to 1000mL;

[0050] The preparation method of above-mentioned Arbidol hydrochloride injection emulsion is as follows:

[0051] Weigh each component according to the above proportion, add Arbidol hydrochloride, soybean lecithin, Tween 80, gum arabic, n-propanol to soybean oil, heat and stir to dissolve as oil phase; add glycerin and vitamin C to In 350mL water for injection, heat and stir to dissolve as the water phase; add the oil phase to the water phase under shear and mix to make colostrum, shear speed 7000r / min, shear time 15min; add water for injection to 1000ml and add acetic acid- The sodiu...

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Abstract

The invention relates to the technical field of medicine, in particular to an injection emulsion of arbidol hydrochloride and a preparation method thereof. The arbidol hydrochloride injection emulsion includes the following components: arbidol hydrochloride, emulsifier, co-emulsifier, oil for injection, isotonicity regulator, pH regulator, antioxidant and water for injection; wherein, the The emulsifiers were soybean lecithin and Tween 80, and the co-emulsifiers were gum arabic and n-propanol. The preparation method of the arbidol hydrochloride injection emulsion provided by the invention adopts a high-pressure homogenization process to encapsulate the medicine in the emulsion, the drug loading of the preparation is increased, and the solubility and bioavailability of the arbidol hydrochloride are improved, The number of times of administration is reduced, the side effects and irritation are reduced, and the stability of the preparation is high, which solves the problem of easy precipitation of drugs during storage and use of conventional injection emulsions; Can be used for industrial scale-up production.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an injection emulsion of arbidol hydrochloride and a preparation method thereof. Background technique [0002] Arbidol hydrochloride (also known as Arbidol hydrochloride, Arbidol), its chemical name is: 6-bromo-4-(dimethylaminomethyl)-5-hydroxy-1-methyl-2-(phenylthio) Methyl)-1H-indole-3-carboxylic acid ethyl ester hydrochloride, is an antiviral drug developed by the Soviet Medicinal Chemistry Research Center, as a treatment for A, B influenza virus and other acute respiratory virus infections. Prophylactic and therapeutic drugs can significantly improve the clinical symptoms of patients. [0003] Arbidol hydrochloride is a drug that is insoluble in water. Arbidol hydrochloride injection prepared by conventional preparation methods has low bioavailability due to its low water solubility and short half-life. And the drug is prone to precipitation during use, and the drug stabil...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K31/4045A61K47/10A61K47/24A61K47/26A61K47/36A61K47/44A61P11/00A61P31/12A61P31/16
CPCA61K31/4045A61K9/1075A61K9/0019A61K47/44A61K47/36A61K47/24A61K47/26A61K47/10A61P11/00A61P31/16A61P31/12
Inventor 王立江赵勇征崔永斌刘敬涛安志远刘苗尹灏轩
Owner SHIJIAZHUANG NO 4 PHARMA
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