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Application of bifidobacterium lactis in prevention and treatment of mental disorder

A technology for Bifidobacterium lactis and mental disorders, applied in the field of microorganisms, can solve problems such as unsatisfactory effects of prevention and treatment of mental disorders, and achieve the effects of improving intestinal permeability and preventing and treating mental disorders.

Pending Publication Date: 2021-06-15
ZHONGKE WISBIOM(BEIJING)BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the current effectiveness of prevention and treatment of mental disorders is not satisfactory

Method used

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  • Application of bifidobacterium lactis in prevention and treatment of mental disorder
  • Application of bifidobacterium lactis in prevention and treatment of mental disorder
  • Application of bifidobacterium lactis in prevention and treatment of mental disorder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] This example is used to illustrate Bifidobacterium lactis BL-11 and its performance characteristics.

[0039] 1. Taxonomic characteristics of Bifidobacterium lactis BL-11:

[0040] Observing Bifidobacterium lactis BL-11 under a microscope, the results are as follows figure 1 shown. The physical and chemical test results are shown in Tables 1 and 2.

[0041] Table 1

[0042]

[0043] Table 2

[0044]

[0045]

[0046] + means able to metabolize; - means unable to metabolize.

[0047] 2. Artificial gastric juice and intestinal juice tolerance of Bifidobacterium lactis BL-11:

[0048] Bifidobacteria are a genus of bacteria that are generally not acid fast. In this example, the tolerance of artificial gastric juice and intestinal juice of Bifidobacterium lactis BL-11 of the present invention is tested. At the same time, the Bifidobacterium lactis Bb which is currently preserved in the laboratory has excellent acid resistance and can survive through the gastroin...

Embodiment 2

[0059] This embodiment is used to illustrate the preparation method of BL-11 freeze-dried bacterial powder.

[0060] BL-11 stored bacteria solution was recovered in a water bath at 37°C until the liquid in the cryotube was completely melted; the MRS medium was marked on the MRS medium, and anaerobic culture was carried out at 37°C for 12-24 hours; a single colony was picked and inoculated Put it into an anaerobic culture tube equipped with liquid medium, seal it, and culture it anaerobically at 37°C for 6-12 hours. When the OD600 value of the bacterial liquid is monitored to stop increasing, stop the fermentation; carry out fermentation and production of strains, and culture at a constant temperature of 40°C for 6-12 hours. For 12 hours, maintain the constant pH of the bacterial liquid at 5.4±0.5 until the OD600 value of the bacterial liquid is monitored to stop increasing, and stop the fermentation immediately; collect the bacterial sludge by centrifugation, according to the v...

Embodiment 3

[0062] This embodiment is used to illustrate that BL-11 freeze-dried bacterial powder is used in the production of food.

[0063] The freeze-dried bacteria powder produced by the Bifidobacterium lactis BL-11 provided by the present invention can be used in common food or health food such as yogurt, fermented milk and cheese. Preferably, in the food, the additive dose of Bifidobacterium lactis BL-11 for making yogurt is 1.0×10 6 CFU~1.0×10 8 CFU / kg, more preferably 1.2×10 7 CFU~1.5×10 8 CFU / kg. The production method is direct investment or post-addition. It is used as a fermentation strain for direct injection. After the raw milk is sterilized, it is added in proportion when it is lowered to an appropriate temperature, and then fermented at 40-43°C for 10-48 hours. After stirring and compounding, it is distributed into cups or bags as finished products. When the method of post-addition is added, after the fermentation of yogurt is completed, it is added in a certain propo...

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Abstract

The invention relates to application of bifidobacterium lactis in prevention and treatment of mental disorder, the bifidobacterium lactis is bifidobacterium lactis BL-11, and the preservation number of the bifidobacterium lactis BL-11 is CGMCC (China General Microbiological Culture Collection Center) No.20847. The bifidobacterium lactis provided by the invention can be used for improving the intestinal permeability and reducing the levels of LPS and D-lactic acid in blood, so that the effect of preventing and treating mental disorders is achieved, and the mental disorders comprise anxiety, depression, attention deficit hyperactivity disorder, autism, autism, schizophrenia, hepatic encephalopathy, anorexia nervosa, Tourette disease and Escherberg syndrome.

Description

technical field [0001] The present disclosure relates to the technical field of microbes, and in particular, relates to the use of Bifidobacterium lactis in preventing and treating mental disorders. Background technique [0002] Recent studies have found that gut microbes can regulate brain function and behavior through the gut-brain axis. Gut flora and brain through autonomic nerves, enteric nerves, immune system, olfactory system, enteroendocrine signaling, neurotransmitters, branched-chain amino acids, bile acids, short-chain fatty acids, spinal cord, hypothalamic-pituitary-adrenal axis, peptidoglycan Sugar and other pathways and mediators conduct two-way communication. Bidirectional communication between the gut microbiota and the central nervous system, the microbiota-gut-brain axis, can affect neurodevelopment and function in animals, thereby influencing social behavior. This bidirectional influence of the microbiota-gut-brain axis is affected by internal factors suc...

Claims

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Application Information

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IPC IPC(8): A23L33/135A23C9/123A23C19/00A23C9/16A23L2/52A23G3/36A23G4/12A23G9/36A23K10/16A61K35/745A61P25/18A61P25/14A61P25/22A61P25/24A61P25/00
CPCA23L33/135A23C9/1234A23C19/00A23C9/16A23L2/52A23G3/366A23G4/123A23G9/363A23K10/16A61K35/745A61P25/18A61P25/14A61P25/22A61P25/24A61P25/00A23V2002/00A23V2400/531A23V2200/322Y02A50/30C12N1/20A61P3/04A23V2200/332A23V2200/3204C12R2001/01
Inventor 段云峰张烨梁桦刘智
Owner ZHONGKE WISBIOM(BEIJING)BIOTECHNOLOGY CO LTD
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