Anti-drunkenness, hangover-alleviating and liver-protecting composition and preparation method and application thereof

A technology for relieving alcohol and protecting the liver and a composition, which is applied in the directions of application, drug combination, and pharmaceutical formulation, can solve the problems such as not making substantial progress, and achieve the effects of delaying the absorption rate of ethanol into the blood, increasing the content, and matching rationally.

Pending Publication Date: 2021-06-18
吉林省强参生物技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, no substantial progress has been made in the development of anti-alcohol and liver-protecting drugs through synthetic methods. On the basis of inheriting traditional medicine, vigorously developing natural products for anti-drunk, anti-alcohol, and liver protection has become the current research focus

Method used

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  • Anti-drunkenness, hangover-alleviating and liver-protecting composition and preparation method and application thereof
  • Anti-drunkenness, hangover-alleviating and liver-protecting composition and preparation method and application thereof
  • Anti-drunkenness, hangover-alleviating and liver-protecting composition and preparation method and application thereof

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preparation example Construction

[0034] The present invention also provides a preparation method of the above anti-drunk, anti-alcohol and liver-protecting composition, comprising the following steps:

[0035] A) dissolving pectin and kudzu root extract in deionized water to obtain a mixed aqueous solution;

[0036] B) preparing calcium alginate gel microspheres after dispersing curcumin, citrus flavonoids, and total flavonoids of Hovenia dulcis in sodium alginate solution;

[0037] C) mixing the mixed aqueous solution with calcium alginate gel microspheres to obtain an anti-drunk, anti-alcoholic and liver-protecting composition.

[0038] The invention dissolves pectin and kudzu root extract in deionized water to obtain a mixed aqueous solution. Specifically, pectin and kudzu root extract are dissolved in deionized water, and insoluble impurities are removed by microfiltration.

[0039] The invention prepares calcium alginate gel microspheres after dispersing curcumin, citrus flavonoids and total flavonoids...

Embodiment 1

[0049] 1. A new anti-drunk, anti-drunk and liver-protecting formula provided in this example contains the following components:

[0050] (1) The citrus pectin content is 3% (w / w), the molecular weight is 240kD, and the degree of esterification is 20%;

[0051] (2) Pueraria root extract 1.0% (w / w);

[0052] (3) Curcumin 0.5% (w / w);

[0053] (4) Citrus flavonoids 0.4% (w / w);

[0054] (5) Total flavonoids of Hovenia dulcis 0.35% (w / w);

[0055] The balance is water.

[0056] 2. Preparation method:

[0057] (1) Pectin and kudzu root extract are dissolved in deionized water, and insoluble impurities are removed by microfiltration;

[0058] (2) Curcumin, citrus flavonoids, Hovenia dulcis Fructus total flavonoids are dispersed in a sodium alginate solution with a mass concentration of 1.5wt%, and then the mixed solution is dropped into a calcium chloride solution with a mass concentration of 1.1wt% to form alginic acid Calcium gel microspheres;

[0059] (3) Clean the calcium a...

Embodiment 2

[0081] Example 2 Animal experiments on anti-alcoholic and liver-protecting products:

[0082] 1. Experimental method:

[0083] (1) Experimental animals and groups

[0084] 100 C57BL / 6 mice, male, weighing 15-30g, were adaptively fed for 7 days, and were randomly divided into a blank group (10 mice), a model group (10 mice), and a Neptune Jinzun group (an anti-alcoholic drug sold on the market). , 10), embodiment 1 combined formula group (10), comparative example 1 no pectin combined formula group (10), comparative example 2 pectin group (10), comparative example 3 kudzu root extract group (10 only), comparative example 4 curcumin group: (10), comparative example 5 citrus flavonoids group (10), comparative example 6 hovenia dulcis total flavonoids group (10).

[0085] (2) Modeling and administration

[0086] 1) Modeling method: 90 rats in all groups except the blank group, fasted for 12 hours before the experiment, fed with 0.15mL / 10g body weight with Fuyu Laojiao at 38°.

...

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Abstract

The invention provides an anti-drunkenness, hangover-alleviating and liver-protecting composition. The anti-drunkenness, hangover-alleviating and liver-protecting composition is prepared from the components in percentage: 2%-8% of pectin, 0.5%-2 % of a radix puerariae extract, 0.3%-0.9% of curcumin, 0.1 %-1% of citrus flavones, 0.1%-1% of hovenia dulcis thunb total flavonoids, and the balance of water. According to the anti-drunkenness, hangover-alleviating and liver-protecting composition, the components are reasonable in compatibility and collocation and take effect synergistically, so that the anti-drunkenness effect can be achieved by delaying the speed of ethanol absorption into blood, and the alcoholism-relieving and liver-protecting effects can be achieved by accelerating ethanol decomposition; and meanwhile, the liver-protecting effect is achieved, so that the anti-drunkenness, hangover-alleviating and liver-protecting product can achieve anti-drunkenness, hangover-alleviating and liver-protecting effects.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and in particular relates to an anti-drunk, anti-alcohol and liver-protecting composition, a preparation method and application thereof. Background technique [0002] my country is a big wine consumption country. In 2016, the scale of alcohol consumption was nearly one trillion yuan, of which the consumption of liquor was about 600 billion yuan, and was growing at a rate of about 10%. The consumption of beer was 180 billion yuan. In recent years, the annual consumption was basically the same. Consumption is about 50 billion yuan, with an annual growth rate of about 10%. Alcohol culture permeates the entire history of Chinese civilization. Appropriate drinking can promote blood circulation, dredge collaterals and disperse cold, dispel dampness and relieve pain, adjust mood, eliminate fatigue, relieve tension, etc. However, acute heavy drinking can cause nausea, vomiting, memory loss, att...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K9/16A61K47/36A23L33/125A23L33/105A61P1/16A61P39/02A61K31/12A61K31/732
CPCA61K31/732A61K36/488A61K31/12A61K36/752A61K36/72A61K9/1652A61P39/02A61P1/16A23L33/125A23L33/105A23V2002/00A61K2300/00A23V2200/334A23V2250/5072A23V2250/21A23V2250/2112A23V2250/21162A23V2250/2116
Inventor 张英赵姗贾琳霍虹
Owner 吉林省强参生物技术有限公司
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