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Traditional chinese medicine decoction piece for reducing blood fat and preparation method of traditional chinese medicine decoction piece

A technology of decoction pieces of traditional Chinese medicine and blood lipid lowering, which is applied in the direction of medical formulas, drug combinations, and medical preparations containing active ingredients, etc. The tract absorbs exogenous cholesterol, the body absorbs it well, and the effect of high extract content

Inactive Publication Date: 2021-06-18
王芬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And there are still some patients who have poor curative effect on commonly used blood lipid-lowering drugs, or cannot be applied because of their side effects; and it is inconvenient to carry
Traditional Chinese medicine decoction pieces are a common method of dispensing traditional Chinese medicine in recent years, which has the advantages of convenience, quickness, and portability. However, most of the blood lipid-lowering Chinese medicine decoction pieces in the market are directly compressed from traditional Chinese medicine powder, which has low leaching rate, low absorption rate, and poor curative effect. Not ideal, it can only play the role of auxiliary western medicine in treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Components: 10kg ginkgo leaves, 10kg safflower, 6kg Alisma, 8kg Bupleurum, 15kg Digupi, 3kg mulberry, 6kg medlar, 10kg corn germ, 3kg hawthorn, 0.5kg chitosan, 0.01kg solubilizer. The solubilizer is composed of rhamnolipid and calcium chloride in a mass ratio of 3:1.

[0023] The preparation method of the described blood lipid-lowering Chinese medicinal decoction pieces comprises the following steps:

[0024] (1) Ginkgo biloba, Alisma, Bupleurum, Digupi, and Sangjisi are crushed to 40-60 mesh, and their water content is adjusted to 60-70%, and then fried at 60-70°C with a water content of 30- 40%, cooled to obtain Chinese medicine powder;

[0025] (2) Add 0.01% of its mass aspergillus to the traditional Chinese medicine powder, stir evenly, ferment at 25-30°C for 3 days, and sterilize to obtain a primary fermentation; add 0.03% of its mass to the primary fermentation again. Bacillus, fermented at 22-25°C for 1 day, sterilized to obtain a primary fermented product; obt...

Embodiment 2

[0030] Components: 12kg ginkgo leaves, 10kg safflower, 6kg Alisma, 10kg bupleurum, 18kg Digupi, 5kg mulberry, 8kg medlar, 12kg corn germ, 4kg hawthorn, 0.6kg chitosan, 0.012kg solubilizer. The solubilizer is composed of rhamnolipid and calcium chloride in a mass ratio of 3-4:1.

[0031] The preparation method of the described blood lipid-lowering Chinese medicinal decoction pieces comprises the following steps:

[0032] (1) Ginkgo biloba, Alisma, Bupleurum, Digupi, and Sangjisi are crushed to 40-60 mesh, and their water content is adjusted to 60-70%, and then fried at 60-70°C with a water content of 30- 40%, cooled to obtain Chinese medicine powder;

[0033] (2) Add 0.015% of its mass aspergillus to the traditional Chinese medicine powder, stir evenly, ferment at 25-30°C for 4 days, and sterilize to obtain a primary fermentation product; then add its mass 0.032% waxy product to the primary fermentation product Bacillus, fermented at 22-25°C for 1 day, sterilized to obtain a ...

Embodiment 3

[0038] Components: 15kg ginkgo leaves, 15kg safflower, 8kg alisma, 12kg Bupleurum, 20kg Digupi, 6kg mulberry, 10kg wolfberry, 15kg corn germ, 6kg hawthorn, 1kg chitosan, 0.02kg solubilizer. The solubilizer is composed of rhamnolipid and calcium chloride in a mass ratio of 4:1.

[0039] The preparation method of the described blood lipid-lowering Chinese medicinal decoction pieces comprises the following steps:

[0040] (1) Ginkgo biloba, Alisma, Bupleurum, Digupi, and Sangjisi are crushed to 40-60 mesh, and their water content is adjusted to 60-70%, and then fried at 60-70°C with a water content of 30- 40%, cooled to obtain Chinese medicine powder;

[0041] (2) Add 0.02% of its mass aspergillus to the traditional Chinese medicine powder, stir evenly, ferment at 25-30°C for 4 days, and sterilize to obtain a primary fermentation; then add 0.04% of its mass to the primary fermentation. Bacillus, fermented at 22-25°C for 2 days, sterilized to obtain a primary fermented product; ...

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Abstract

The invention relates to the technical field of hyperlipidemia treatment, in particular to a traditional chinese medicine decoction piece for reducing blood fat and a preparation method of the traditional chinese medicine decoction piece. The traditional chinese medicine decoction piece for reducing blood fat is prepared from the following raw materials of, in parts by weight, 10-15 parts of folium ginkgo, 10-15 parts of flos carthami, 6-8 parts of rhizoma alismatis, 8-12 parts of radix bupleuri, 15-20 parts of cortex lycii radicis, 3-6 parts of herba taxilli, 6-10 parts of fructus lycii, 10-15 parts of corn germ, 3-6 parts of fructus crataegi, 0.5-1 part of an adsorbent and 0.01-0.02 part of a solubilizer. In a preparation process, a microbial inoculum A and a microbial inoculum B are adopted to ferment the raw materials, interaction and conversion between active ingredients in the raw materials can be promoted in a fermentation process, and the bioactive components of a chinese herbal medicine extract are increased; and the prepared traditional chinese medicine decoction piece has a good blood fat reducing effect, meanwhile, the extract content is high, and a body absorption effect is good.

Description

technical field [0001] The invention relates to the technical field of hyperlipidemia treatment, in particular to a blood lipid-lowering traditional Chinese medicine decoction piece and a preparation method thereof. Background technique [0002] Hyperlipidemia is the common name of hyperlipidemia (Hyperlipidemia), also known as "hyperlipoproteinemia" (Hyperlipoproteinemia), refers to excessive blood lipid levels, is the most common form of dyslipidemia (Dyslipidemia). The condition is divided into "primary" and "secondary subtypes". Primary hyperlipidemia usually arises from genetic causes (such as mutations in receptor proteins), while secondary hyperlipidemia arises from other causes, such as diabetes. Lipid and lipoprotein abnormalities are more common in the general population, in addition, some forms of hyperlipidemia may induce acute pancreatitis (Acutepancreatitis). [0003] The clinical manifestations of hyperlipidemia are mainly xanthoma caused by lipid deposition...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K9/20A61P3/06
CPCA61K9/205A61K9/2095A61K36/16A61K36/185A61K36/233A61K36/286A61K36/734A61K36/815A61K36/884A61K36/899A61K2236/19A61K2236/333A61P3/06A61K2300/00
Inventor 王芬
Owner 王芬