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Injectable adhesive hydrogel as well as preparation method and application thereof

A hydrogel, adhesive technology, applied in pharmaceutical formulations, organic active ingredients, non-central analgesics, etc., can solve the problems of low drug availability, short adhesion time, weak adhesion, etc., to achieve superior Effects of treatment, excellent mechanical properties, good biocompatibility

Pending Publication Date: 2021-06-22
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Problems solved by technology

However, due to the weak alkalinity of the intestinal tissue, the adhesion of the above-mentioned hydrogels in the intestinal tract is still weak, mainly in the short adhesion time, weak adhesion, etc.
In addition, since 5-ASA is a hydrophobic drug, after the hydrogel is loaded with 5-ASA in various forms, it still exists in the original insoluble form after being released into the intestinal juice, and the solubility is less than 1 mg / mL, and the drug availability is very low

Method used

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  • Injectable adhesive hydrogel as well as preparation method and application thereof
  • Injectable adhesive hydrogel as well as preparation method and application thereof
  • Injectable adhesive hydrogel as well as preparation method and application thereof

Examples

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Embodiment

[0041] Example (1) Formation of G4-ASA complex and evaluation of drug solubility

[0042] The fourth generation polyamide-amine dendrimers with amino terminals (abbreviated as G4 PAMAM, reference: Peng Xiaochun. et al. Synthesis of low-generation polyamide-amine dendrimers [J]. Journal of Jishou University (Nature Science Edition), 2005 (03): 65-68.) was dissolved in deionized water and then dissolved in different concentrations of 5-ASA, and the mixture was sonicated for 2 hours to form a stable G4-ASA complex. The appearance of the G4-ASA complex and 5-ASA suspension was recorded at a macroscopic perspective with a camera. The morphology of G4 PAMAM and G4-ASA nanoparticles was determined by TEM (Transmission Election Microscopy). Potentials Potentials were determined by and Dynamic light scattering. The absorption spectra of G4PAMAM, 5-ASA and G4-ASA were measured by a spectrometer (UV-vis spectrometer) to confirm the formation of the G4-ASA complex. In order to evaluate...

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Abstract

The invention provides injectable adhesive hydrogel as well as a preparation method and application thereof, and belongs to the technical field of medical drug loading. The preparation method of the injectable adhesive hydrogel comprises the following steps: (1) dissolving fourth-generation dendrimer polyamide-amine in deionized water, adding 5-aminosalicylic acid into the deionized water, and carrying out ultrasonic treatment on the mixed solution to form a stable compound; and (2) mixing an oxidized dextran solution with the compound in the step (1) to form the injectable adhesive hydrogel. The hydrogel has the advantages of being high in injectability, good in adhesion and the like, the solubility and the drug availability of the insoluble drug 5-aminosalicylic acid are greatly improved, the hydrogel can better maintain the length of the intestinal tract and remarkably reduce infiltration of inflammatory cells of the intestinal tract, and the hydrogel is optimal in disease activity index, histological score and immunohistochemical result and can be well used as a drug delivery medium for treating ulcerative colitis.

Description

technical field [0001] The invention belongs to the technical field of medical drug delivery, and in particular relates to an injectable adhesive hydrogel and a preparation method and application thereof. Background technique [0002] Ulcerative colitis (UC) is a chronic nonspecific intestinal disease involving the colon and rectum with clinical manifestations such as abdominal pain, diarrhea, and bloody stool. According to reports, the annual incidence of UC in European and American countries can reach as high as 8-246 cases per 100,000 people. Mild and moderate UC patients usually take oral medication to relieve disease symptoms and improve quality of life. 5-Aminosalicylic acid (5-ASA) is one of the most clinically used drugs for the treatment of ulcerative colitis. [0003] Sulfasalazine (SSZ), as an orally administered prodrug of 5-ASA, is the first-line drug for the treatment of UC in clinical practice. It has the advantages of reducing the loss of 5-ASA in the stomac...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/606A61K47/36A61K47/59A61P1/00A61P1/04A61P29/00
CPCA61K31/606A61K9/06A61K9/0024A61K9/0031A61K47/595A61K47/36A61P1/04A61P1/00A61P29/00
Inventor 崔文国王正廷赵力王非
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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