Thermosensitive Filler Composition

The technology of filler and composition is applied in the field of temperature-sensitive filler composition for injection, which can solve the problems of affecting the treatment effect, destroying the stability and treatment effect of polylactic acid microspheres, and achieving the effect of prolonging the shelf life.

Active Publication Date: 2022-04-29
劢恪瑟(上海)生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because polylactic acid and cross-linked hyaluronic acid hybrid gel are in a mixed state for a long time, that is, polylactic acid is in water for a long time, polylactic acid will gradually hydrolyze during storage, which will affect the therapeutic effect. Bacteria further destroy the stability and therapeutic effect of polylactic acid microspheres

Method used

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  • Thermosensitive Filler Composition
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  • Thermosensitive Filler Composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Add 2 g of L-polylactic acid (PLLA) with a molecular weight of 500,00 to 16 mL of dichloromethane to dissolve, and then add dropwise to 400 mL of 1% polyvinyl alcohol (viscosity of 22.6 mPa.s) aqueous solution. , stirred at room temperature for 1 hour, heated to 45°C, removed dichloromethane to obtain a reaction solution, filtered the reaction solution to collect the filter cake, sieved out microspheres with an average particle size of 20-80 μm, and vacuum-dried to obtain 1.3 g of 20-80 μm polylactic acid Microspheres, which are subpackaged into 60 mg microsphere sample 1 for each bottle for later use. For its optical micrograph, see figure 2 .

[0038] Put 2g of methylcellulose (SM 400) and 0.5g of sodium alginate in a 200ml beaker, add 60mL of 90°C hot water, stir to dissolve, and store in a 4°C refrigerator for later use; add 20mL (0.4g / ml) polyethylene glycol and 14mL (0.25g / ml) of sodium citrate, adjust the pH to 7.4, set the volume to 100mL, stir at 4°C for 12...

Embodiment 2

[0041] Add 2 g of racemic polylactic acid (PDLLA) with a molecular weight of 15,000 to 4 mL of dichloromethane to dissolve, then add dropwise to 200 mL of 1% polyvinyl alcohol (viscosity of 22.6 mPa.s) aqueous solution, and the dropwise addition is complete , stir at room temperature for 1 hour, heat up to 45°C, remove dichloromethane to obtain a reaction solution, filter the reaction solution to collect the filter cake, sieve out microspheres with an average particle size of 20-80 μm, and vacuum-dry to obtain 1.4 g of 20-80 μm polylactic acid The microspheres are used as microsphere sample 2 for later use; or they are subpackaged into 60 mg microsphere sample 2 for each bottle for later use. For its optical micrograph, see image 3 .

[0042]Put 20g of Soluplus in a 100ml beaker, add 80mL of 0.05M PBS with pH7.4, stir to dissolve, and constant volume to obtain 100mL of gel. Heat and sterilize the temperature-sensitive gel to obtain temperature-sensitive gel sample 2, and sto...

Embodiment 3

[0046] Add 2 g of polycaprolactone (PCL) with a molecular weight of 50,000 to 12 mL of dichloromethane to dissolve, then add dropwise to 200 mL of a 1% polyvinyl alcohol (viscosity of 22.6 mPa.s) aqueous solution, and the dropwise addition is complete , stirred at room temperature for 1 hour, heated up to 45°C, removed dichloromethane to obtain a reaction solution, filtered the reaction solution to collect the filter cake, sieved out microspheres with an average particle size of 20-80 μm, and vacuum-dried to obtain 1.5 g of 20-80 μm polyhexene The lactone microspheres are used as the microsphere sample 3 for later use; or it is subpackaged into each bottle of 60 mg microsphere sample 3 for later use. For its optical micrograph, see Figure 4 .

[0047] Place 18g of poloxamer 407, 2g of poloxamer 188, 0.5g of sodium carboxymethylcellulose (viscosity of 12000mPa.s) and 0.25g of polyethylene oxide (PEO) with an average molecular weight of 5 million in a 100ml beaker , add 80mL ...

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Abstract

The present invention provides a temperature-sensitive filler composition. The temperature-sensitive filler composition includes a temperature-sensitive mixed powder that can form a temperature-sensitive gel when added with water. The temperature-sensitive mixed powder is prepared by the following method: injecting Polymer microspheres that can stimulate collagen production in vivo are dispersed in a temperature-sensitive gel, and the temperature-sensitive gel is liquid when the ambient temperature is lower than 34°C and is in a gel state at 34-37°C, wherein the polymer microspheres The dosage ratio of the thermosensitive gel is 60mg: 0.25-6mL, preferably 60mg: 2mL; and the thermosensitive gel dispersed with polymer microspheres is freeze-dried to obtain the mixed powder. Compared with the case of injecting polymer microspheres alone or using gel injection alone, not only can the filling effect be produced immediately with the help of thermosensitive gel, but also the continuous self-filling effect can be continuously produced subsequently.

Description

technical field [0001] The invention relates to an injectable temperature-sensitive filler composition for skin regeneration / filling, a preparation method and application thereof. Background technique [0002] In recent years, with the development of the plastic surgery industry, the products of plastic surgery are constantly increasing, which in turn makes the way of plastic surgery is also constantly upgraded, from the previous mainly based on surgery, is constantly changing to non-invasive injection Mainly fillers. Therefore, injectable filler products are constantly being developed. [0003] At present, dermal fillers on the market are divided into the following three categories according to whether they can be absorbed by the body: 1. Rapidly absorbable dermal fillers, mainly including hyaluronic acid and its derivatives, collagen, etc.; 2. Slowly absorbable dermal fillers Fillers mainly include L-polylactic acid (PLLA), etc.; 3. Non-absorbable dermal fillers mainly i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/50A61L27/26
CPCA61L27/50A61L27/26A61L2400/06A61L2400/12C08L67/04C08L29/04C08L5/04C08L71/02C08L1/286C08L51/08C08L1/28
Inventor 张国华
Owner 劢恪瑟(上海)生物技术有限公司
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