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Litsea cubeba essential oil-hydroxypropyl-beta-cyclodextrin inclusion compound as well as preparation method and application thereof

A technology of cyclodextrin inclusion compound and hydroxypropyl group, which is applied in the field of litsea cubeba essential oil-hydroxypropyl-β-cyclodextrin inclusion compound and its preparation, can solve the problem of poor sterilization effect and citrus green preservative Insufficient stability and other issues

Inactive Publication Date: 2021-07-06
HUNAN AGRI PRODS PROCESSING INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the technical problems of poor stability and poor bactericidal effect of citrus green preservatives in the prior art, and provide a litsea cubeba with better water solubility and stability and better antibacterial effect Essential oil-hydroxypropyl-β-cyclodextrin inclusion complex

Method used

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  • Litsea cubeba essential oil-hydroxypropyl-beta-cyclodextrin inclusion compound as well as preparation method and application thereof
  • Litsea cubeba essential oil-hydroxypropyl-beta-cyclodextrin inclusion compound as well as preparation method and application thereof
  • Litsea cubeba essential oil-hydroxypropyl-beta-cyclodextrin inclusion compound as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A litsea cubeba essential oil-hydroxypropyl-β-cyclodextrin inclusion compound (LCEO-HP-βCD-IC), the formation principle of which can be found in figure 1 ,

[0038] Its preparation method comprises the following steps:

[0039] (1) Slowly add 1 g of litsea cubeba essential oil solution dropwise to 4.2 g of hydroxypropyl-β-cyclodextrin solution; keep stirring at 44°C for 2 hours, cool to room temperature, and place in a refrigerator at 4°C overnight to obtain mixture. The mixed solution was vacuum filtered, and the precipitate was washed twice with double distilled water and absolute ethanol solution respectively.

[0040] (2) The washed precipitate was collected and dried in an oven at 50°C to constant weight to obtain LCEO-HP-βCD-IC powder.

Embodiment 2

[0063] Single factor experiments were used to study the effects of different wall-to-core ratios, inclusion time and inclusion temperature on inclusion yield.

[0064] Effect of wall-core ratio on encapsulation rate: slowly add 1g of Litsea Cubeba essential oil solution dropwise into 1g, 2g, 4g, 6g, 8g, 10g of hydroxypropyl-β-cyclodextrin solutions; at 44℃ Stir continuously for 2 hours, and prepare the litsea cubeba essential oil-hydroxypropyl-β-cyclodextrin inclusion compound according to the method of Example 1.

[0065] Effect of inclusion temperature on inclusion rate: Add 1g of litsea cubeba essential oil solution dropwise slowly to 4g of hydroxypropyl-β-cyclodextrin solution; Stir continuously for 2 hours, and prepare the litsea cubeba essential oil-hydroxypropyl-β-cyclodextrin inclusion compound according to the method of Example 1.

[0066] Influence of inclusion temperature on inclusion rate: slowly add 1g of litsea cubeba essential oil solution dropwise to 4g of hyd...

Embodiment 3

[0069] According to the single factor test results, the level of the response surface factor was set, using the Design-Expert software, according to the Box-Behnken central combination experiment design principle, the wall-to-core ratio (X 1 ), inclusion temperature (X 2 ), inclusion time (X 3 ) as the independent variable, code the above factors respectively, and take the inclusion yield of Litsea Cubeba essential oil-HP-β-CD inclusion compound as the response value, design a response surface analysis with three factors and five levels with a total of 17 experimental points In the experiment, the optimal process conditions for the preparation of Litsea Cubeba Essential Oil-HP-β-CD inclusion compound were screened, and the experimental factors and levels were selected in the following table.

[0070]

[0071]

[0072]

[0073] Regression analysis and significance test were carried out on the above regression equation, and the results are shown in the table above. F...

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Abstract

The invention discloses a litsea cubeba essential oil-hydroxypropyl-beta-cyclodextrin inclusion compound as well as a preparation method and application thereof, the litsea cubeba essential oil-hydroxypropyl-beta-cyclodextrin inclusion compound takes hydroxypropyl-beta-cyclodextrin as a carrier, and litsea cubeba essential oil is included in the hydroxypropyl-beta-cyclodextrin to form the inclusion compound. The preparation method comprises the following steps: adding a litsea cubeba essential oil solution into hydroxypropyl-beta-cyclodextrin for inclusion to obtain an inclusion solution; cooling the inclusion solution, and filtering to obtain a precipitate; and drying the precipitate to obtain the litsea cubeba essential oil-hydroxypropyl-beta-cyclodextrin inclusion compound. The litsea cubeba essential oil-hydroxypropyl-beta-cyclodextrin inclusion compound disclosed by the invention is better in water solubility and stability and better in antibacterial effect, can be used for controlling fungal diseases of citrus, and has a very important significance in the field of green preservation of citrus.

Description

technical field [0001] The invention belongs to the field of agricultural products, and relates to a litsea cubeba essential oil-hydroxypropyl-β-cyclodextrin inclusion compound and a preparation method and application thereof. Background technique [0002] Citrus is the fruit with the largest cultivation area and output in my country; citrus fruit is rich in vitamin C, flavonoids, carotenoids and other nutrients; citrus fruit in my country is mainly sold fresh, and citrus is susceptible to fungal diseases during storage, Penicillium italicum, Penicillium, green mold, and acid rot caused by Penicillium digitatum and Geotrichum candidum are the main postharvest fungal diseases of citrus, and commercial fungicides (imazalil, fludioxonil, prochloraz, etc.) are difficult to effectively Control it; chemical fungicides such as biphenylphenol sodium salt (SOPP) can effectively inhibit citrus fungal diseases, but their side effects are relatively large, they are easy to damage fruits, ...

Claims

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Application Information

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IPC IPC(8): A01N65/24A01N25/10A01N25/18A01P3/00A23B7/144
CPCA01N65/00A01N65/24A01N25/10A01N25/18A23B7/144
Inventor 朱向荣王银红单杨李高阳付复华苏东林陶能国龚亮丁胜华
Owner HUNAN AGRI PRODS PROCESSING INST
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