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A strontium and simvastatin double-loaded bone repair microsphere and its preparation method

A simvastatin, dual-loading technology, applied in the field of biomedical materials, can solve the problems of complex synthesis process of drug-loaded microspheres, complex synthesis process, low drug loading, etc., to improve bone tissue regeneration and repair, with broad application prospects, The effect of good osteogenic activity

Active Publication Date: 2022-02-01
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a strontium and simvastatin double-loaded bone repair microspheres and its preparation method to solve the problem of complex synthetic process and low drug loading of the existing drug-loaded microspheres. and drug burst issues
[0007] The beneficial effects of the present invention are: the present invention prepares double-loaded hydroxyapatite microspheres through a one-step method, the preparation method is simple and easy, and overcomes the problem of complex synthesis process of existing drug-loaded biological materials

Method used

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  • A strontium and simvastatin double-loaded bone repair microsphere and its preparation method
  • A strontium and simvastatin double-loaded bone repair microsphere and its preparation method
  • A strontium and simvastatin double-loaded bone repair microsphere and its preparation method

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Embodiment 1

[0030] A method for preparing strontium and simvastatin double-loaded bone repair microspheres, comprising the following steps:

[0031] Slowly drop 10mL of 93mM creatine phosphate solution into 30mL of 29.00mM CaCl 2 , 4.33mM SrCl 2The solution was stirred magnetically for 30 min at room temperature. The pH value of the above mixed solution was adjusted to 10±0.1 by adding 25 mL of 1M NaOH solution dropwise to obtain a pre-reaction solution of strontium-loaded hydroxyapatite microspheres. Then add 1 mL of 50 mg / mL simvastatin-ethanol solution, ultrasonically disperse for 3 minutes, then put it into an autoclave, and heat to 120 °C in a microwave hydrothermal reactor (MDS-6G, Sineo, Shanghai, China) to keep the reaction 30 minutes to complete self-assembly. Finally, it was cooled to room temperature, washed with deionized water for 30 minutes, centrifuged at 3000 rpm for 10 minutes, and freeze-dried to obtain strontium and simvastatin double-loaded bone repair microspheres,...

Embodiment 2

[0033] A method for preparing strontium and simvastatin double-loaded bone repair microspheres, comprising the following steps:

[0034] Prepare strontium-loaded hydroxyapatite microspheres pre-reaction solution according to the method of Example 1, then add 1mL 50mg / mL simvastatin-water solution, ultrasonically disperse for 5 minutes, then put it in an autoclave, and heat it in a microwave hydrothermal reactor Heating to 120°C in medium temperature and maintaining the reaction for 30 minutes to complete the self-assembly. Cool to room temperature, wash with deionized water for 60 min, centrifuge at 3000 rpm for 10 min, and freeze-dry to obtain strontium and simvastatin double-loaded bone repair microspheres, namely mesoporous hydroxyapatite microspheres.

Embodiment 3

[0036] A method for preparing strontium and simvastatin double-loaded bone repair microspheres, comprising the following steps:

[0037] Prepare the strontium-loaded hydroxyapatite microsphere pre-reaction solution according to the method of Example 1, then add 1mL100mg / mL simvastatin-ethanol solution, ultrasonically disperse for 3 minutes, then put it into an autoclave, and heat it in a microwave hydrothermal reactor Heating to 140°C in medium temperature, keeping the reaction for 60 minutes, to complete the self-assembly. Cool to room temperature, wash with deionized water for 30 minutes, then centrifuge at 3000 rpm for 10 minutes, and freeze-dry to obtain strontium and simvastatin double-loaded bone repair microspheres, namely mesoporous hydroxyapatite microspheres.

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Abstract

The invention discloses a strontium and simvastatin double-loaded bone repair microsphere and a preparation method thereof. The preparation method comprises: preparing strontium by one-step method of microwave hydrothermal reaction with phosphate, calcium salt, strontium salt and simvastatin and simvastatin dual-loaded bone repair microspheres. The method is simple and easy to prepare multifunctional strontium and simvastatin double-loaded bone repair microspheres that promote angiogenesis and osteogenesis, and can realize long-term sustained release of strontium and simvastatin, which is beneficial to the growth of cells and bone tissue. and the encapsulation rate of SIM is as high as 71.9wt%. It can be used as a direct contact treatment of drugs in the repair of large bone defects.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a strontium and simvastatin double-loaded bone repair microsphere and a preparation method thereof. Background technique [0002] Drug-loaded microspheres control the drug release rate and deliver the drug to specific tissues and organs by changing the way the drug enters the human body and the distribution in the body, so as to improve the efficacy and bioavailability of the drug and reduce the side effects . Because of its high drug utilization, controlled release, safety and effectiveness, drug-loaded microspheres are widely used in the manufacture of drug carriers that can release drugs in a targeted manner, and have become the current research topic for biofunctional materials. focus direction. In recent years, a large number of studies have shown that vascularization plays an important role in the process of bone regeneration, and vascularization can provide ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04A61L27/54A61L27/12A61L27/50A61K33/24A61K31/366A61K9/52A61K47/02A61P19/08
CPCA61L27/047A61L27/54A61L27/12A61L27/50A61K33/24A61K31/366A61K9/501A61P19/08A61L2300/412A61L2430/02A61L2300/102A61L2300/216A61L2300/602A61K2300/00
Inventor 李玉宝李根李吉东左奕
Owner SICHUAN UNIV
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