A kind of anti-thrombotic/anti-tumor function vascular covered stent and preparation method thereof

Abstract

The invention discloses an anti-thrombotic / anti-tumor functional vascular covered stent and a preparation method thereof. The anti-thrombotic / anti-tumor functional vascular covered stent is composed of a metal stent and a fabric coating that carries drugs inside and outside respectively. The layer has a capsule interlayer. The film is loaded with anti-thrombotic drugs on the inner layer and anti-tumor drugs on the outer drug capsule interlayer. Using covalent cross-linking technology, the inner layer of the film is coated with an anti-thrombotic coating, so that the inner layer of the film can resist thrombosis and fast Endothelialization meets the treatment requirements of endovascular repair for aortic aneurysms. Curcumin and metformin microspheres are loaded on the outer cavity interlayer of the film, which can be used for anti-tumor treatment of aortic aneurysms, and achieve long-term sustained release of drugs, which is effective It can prevent restenosis, inhibit tumor growth, and reduce the risk of blood vessel rupture, especially for patients with abdominal aortic aneurysm.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to an anti-thrombotic / anti-tumor function vascular covered stent and a preparation method thereof. Background technique [0002] An aneurysm is a persistent dilation of the vessel wall caused by damage to the weakened artery wall. This disease often occurs in the aorta and main arteries of the lower extremities. Vascular stent implantation is one of the effective methods of minimally invasive surgery for the treatment of cardiovascular diseases. The advantages are small trauma, low risk, fast recovery and relatively low cost. Vascular stents refer to implantable medical devices that can provide sufficient mechanical support for blood vessels, maintain patency in blood vessels, and complete blood vessel repair tasks without causing local or systemic tissue damage. [0003] Common vascular stents include bare stents, drug-coated stents, and covered stents. F...

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Problems solved by technology

The method of coating the drug is ultrasonic spraying. Since there are many factors that affect the effect of ultrasonic atomization spraying equipment, such as: liquid viscosity, mixing degree of different components and dynamic characteristics of the liquid, etc., the use of this method has too many restrictions on the drug used. Therefore, the application of the method is difficult

Moreover, the drug coated by this method will burst into release, and has no obvious inhibitory effect on thrombus formation.

Moreover, the covered stent does not have the dual functions of anti-tumor and anti-thrombotic, and it is prone to problems such as poor biocompatibility, restenosis, and poor endothelialization in mid- and long-term clinical trials, resulting in 15-20% of patients with postoperative Complications requiring secondary surgery

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