A kind of cross-linked chitosan hemostatic powder and preparation method thereof

Abstract

The invention provides a cross-linked chitosan hemostatic powder and a preparation method thereof. The liquid absorption of the cross-linked chitosan hemostatic powder is more than 30 times its own weight, and it is prepared by the following method: the shell The polysaccharide raw material is added to the organic solvent for stirring and swelling, and then the acid solution is added dropwise under the stirring state. After reacting for 0.5h to 2h, a crosslinking agent is added to the reaction solution for crosslinking reaction. After the reaction is completed, filter, wash, Dry and serve. The cross-linked chitosan hemostatic powder provided by the invention has a good hemostatic effect on serious local bleeding on the skin surface under emergency conditions, or wounds with a large amount of bleeding such as arterial bleeding; the preparation method provided does not need to dissolve chitosan to make a solution Then carry out the cross-linking reaction, the original powder form of chitosan is well preserved in the preparation process, and the preparation process is simple and the cost is low.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a chitosan hemostatic powder and a preparation method thereof. Background technique [0002] Hemorrhage is one of the causes of death in trauma patients, and rapid and effective control of hemorrhage can significantly reduce mortality. As a natural marine alkaline polysaccharide, chitosan has good biocompatibility, good hemostatic effect, and has the functions of promoting healing and antibacterial, so it is the first choice for hemostatic materials. Chitosan hemostatic powder does not rely on normal coagulation factors and acts independently. Its positively charged product particles cross-combine with negatively charged red blood cells to form blood clots. The coagulation process is a physical action without any adverse reactions. [0003] Chitosan hemostatic powder in the prior art, its composition mainly is chitosan, carboxymethyl chitosan, chitosan lactic acid...

AI Technical Summary

Problems solved by technology

This method needs to add a sufficient amount of cross-linking agent to make the cross-linked chitosan precipitate. When the cross-linking agent is added in a small amount, the formed cross-linked chitosan has a small degree of cross-linking and a high solubility in water, so it cannot be precipitated. It can be made into finished products by freeze-drying, and the cost is relatively high

This application has prepared cross-linked chitosan by adding a sufficient amount of cross-linking agent, but its cross-linking is too large, insoluble in water, and has poor hemostatic effect

[0006] The patent application with application number 2014107301353 discloses a chitosan hemostatic powder formed by covalent cross-linking and its preparation method, specifically: making chitosan into an aqueous solution, and then adding a cross-linking agent to the chitosan aqueous solution , fully stirred and mixed, then freeze-dried to obtain a sponge-like product, the preparation process is complicated and the cost is high

[0007] The above reactions are made of chitosan into a solution, and then a cross-linking agent is added to carry out the cross-linking reaction. Although the uniformity of the reaction is guaranteed, the preparation process is complicated, the cost is high, and the hemostatic effect of the product is also poor.

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