Activated anti-OX40 antibody, production method and application

A technology of antibody and heavy chain antibody, applied in the direction of biochemical equipment and methods, applications, antibodies, etc., can solve problems such as incomplete consistency, difficult to predict adverse reactions, etc., and achieve low heterology, high affinity, and clear amino acid sequence structure Effect
CN113135994APending Publication Date: 2021-07-20MABWELL (SHANGHAI) BIOSCIENCE CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
MABWELL (SHANGHAI) BIOSCIENCE CO LTD
Publication Date
2021-07-20

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Abstract

The present invention provides an antibody or fragment thereof that expresses an activated receptor (OX40) on the surface of activated CD4+T, CD8+T cells, and the use of the antibody or fragment thereof for the prevention or treatment of diseases. The antibody disclosed by the invention is high in affinity to OX40 and obvious in effect of activating an OX40 signal channel; the antibody has a relatively broad-spectrum immunopotentiation effect, and can enhance T cell response immune memory; and good tumor inhibiting and killing effects are achieved in animal model in-vivo experiments, and good clinical application prospects are achieved.
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Description

technical field

[0001] The invention belongs to the field of antibody engineering, and specifically relates to an anti-OX40 antibody, its production method and application, in particular to an anti-human OX40 humanized antibody, its recombinant expression method and its application in the treatment of solid tumors. Background technique

[0002] OX40, also known as CD134, ACT45, TNFRSF4, is a member of the tumor necrosis factor receptor (TNFR) superfamily and is an activating receptor expressed on the surface of activated CD4+T and CD8+T cells. OX40 signaling can activate the downstream NF-κB, PI3K and PKB pathways, and the continuous activation of these pathways can ultimately prolong the survival time of T cells, expand T cell memory, and promote the cell killing ability of T cells; The differentiation and activity of regulatory T cells (Treg) improves the immunosuppressive effect in the tumor microenvironment and further enhances the function of effector T cells.

[0003] ...

Claims

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