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Preparation technology of chlorobenzene glyceryl ether

A technology for the preparation of chlorphenesin, which is applied in the direction of ether preparation, ester reaction to prepare ether, organic compound/hydride/coordination complex catalyst, etc., can solve the problem of inability to effectively control the reaction process and obtain chlorphenesin The problems such as instability of the production rate can be solved, and the effect of easy operation, simple preparation method and improved stability can be achieved.

Active Publication Date: 2021-07-23
菏泽新东方日化科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] In view of the above-mentioned related technologies, the inventor believes that the synthesis process of the above-mentioned technology cannot effectively control the reaction process when synthesizing chlorphenesin, resulting in unstable yield of chlorphenesin

Method used

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  • Preparation technology of chlorobenzene glyceryl ether
  • Preparation technology of chlorobenzene glyceryl ether
  • Preparation technology of chlorobenzene glyceryl ether

Examples

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Effect test

preparation example 1

[0038] A catalyst, the preparation method is: disperse 7g of fumed silicon dioxide and 5g of vitamin E in 15g of absolute ethanol, then add 5g of alkyl ammonium bromide and stir evenly, heat to 40°C and continue stirring until the absolute alcohol is completely volatilized That is, the catalyst is prepared.

[0039] The alkylammonium bromide is tetrapropylammonium bromide, and the specific surface area of ​​the fumed silica is 350-410m 2 / g, the vitamin E is α-tocopherol.

preparation example 2-3

[0041] Preparation examples 2-3 are all based on preparation example 1, and the difference from preparation example 1 is only that the amount of each raw material is different, see Table 2 for details.

[0042] Preparation example Preparation Example 1 Preparation example 2 Preparation example 3 Fumed silica (g) 7 3 12 Vitamin E(g) 5 10 1 Alkyl ammonium bromide (g) 5 3 7

preparation example 4-6

[0044] Preparation Examples 4-6 are all based on Preparation Example 1, and the only difference from Preparation Example 1 is that the types of alkyl ammonium bromide used are different, see Table 3 for details.

[0045] Preparation example Preparation Example 4 Preparation Example 5 Preparation Example 6 Alkyl ammonium bromide Decyltrimethylammonium bromide Octadecyltrimethylammonium bromide cetyltrimethylammonium bromide

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Abstract

The invention relates to the field of synthesis of cosmetic additives, and particularly discloses a preparation technology of chlorobenzene glyceryl ether. 3-chloro-1, 2-propylene glycol and parachlorophenol are adopted as main raw materials, and a catalyst is added to prepare the chlorobenzene glyceryl ether. The catalyst is prepared from, by weight, 3-12 parts of fumed silica, 1-10 parts of vitamin E and 3-7 parts of alkyl ammonium bromide. According to the preparation technology, the reaction process can be effectively controlled, and the stability of the yield of the chlorobenzene glyceryl ether is improved.

Description

technical field [0001] The application relates to the field of synthesis of cosmetic additives, more specifically, it relates to a preparation process of chlorphenesin. Background technique [0002] Chlorphenesin is also known as chlorophenol ether and chlorphenesin, and its chemical name is 3-(4-chlorophenoxy)-1,2-propanediol. Chlorphenesin is widely used in the fields of medicine and cosmetics due to its antifungal effect. [0003] In terms of medicine, chlorphenesin is mainly used as a muscle relaxant, and can also be used as an antifungal drug, and is suitable for anti-bacteria, vaginal mold, trichomonas and other diseases. There are many drug dosage forms and are widely used. [0004] In cosmetics, chlorphenesin can effectively resist gram-positive bacteria and gram-negative bacteria, especially has strong bactericidal activity against Aspergillus niger and Penicillium pinophilum, and is also very effective against Candida albicans and Saccharomyces cerevisiae Therefo...

Claims

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Application Information

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IPC IPC(8): C07C41/16C07C43/23B01J31/02
CPCC07C41/16B01J31/0239B01J2231/4288C07C43/23
Inventor 陈晓辉蔡建陈坤薛天辉
Owner 菏泽新东方日化科技有限公司
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