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Sulfurnegative ion fluorescent probe material as well as preparation method and application thereof

A fluorescent probe and sulfur anion technology, which is applied in the direction of luminescent materials, material analysis and material analysis through optical means, can solve the problem of weakening the interaction between the sensor and the target anion, and achieve the effect of high sensitivity and high selectivity

Active Publication Date: 2021-07-23
GANNAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, due to the strong hydration properties of sulfide anion, the interaction between the sensor and the target anion will be weakened
The fluorescent probes of sulfur anions formed by the above substances still have great difficulties and challenges in the application of fluorescent sensors that expect to obtain high selectivity and high sensitivity; in addition, in order to obtain the best detection effect, it is very necessary The characteristics of rapid response for sulfur anions, and the above-mentioned substances are also lacking in this characteristic when they are used as fluorescent probes for sulfur anions

Method used

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  • Sulfurnegative ion fluorescent probe material as well as preparation method and application thereof
  • Sulfurnegative ion fluorescent probe material as well as preparation method and application thereof
  • Sulfurnegative ion fluorescent probe material as well as preparation method and application thereof

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Embodiment 1

[0042] A sulfide ion fluorescent probe material BZEM, which has the following structure:

[0043]

[0044] The preparation route of the above-mentioned sulfide anion fluorescent probe material BZEM is shown in the following formula:

[0045]

[0046] The preparation method of the sulfide anion fluorescent probe material BZEM is as follows.

[0047] S1. In a three-necked flask provided with a condensing device, dissolve 5mmol of 2-(3,5,5-trimethylcyclohex-2-enyl) malononitrile and 5mmol of p-hydroxybenzaldehyde in 15ml of ethanol Add 5 drops of piperidine and 5 drops of acetic acid, reflux for 4 hours, then cool the resulting mixture, pour it into ice water, collect the filter residue after filtration, and then use column chromatography (stationary phase: 200-300 mesh silica gel, mobile Phase: Petroleum ether: ethyl acetate = 1:2, v / v) purification to obtain compound 1 with a yield of 65%.

[0048] 1 H NMR (400MHz, CDCl 3 )δ7.42(d, J=8.0Hz, 2H), 7.24(s, 1H), 7.01(d, J...

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Abstract

The invention relates to a sulfur negative ion fluorescent probe material which has the following structural general formula: R1 and R2 are independently selected from C1-C22 alkyl groups, and the alkyl groups are selected from linear alkyl groups or branched alkyl groups. The sulfur negative ion fluorescent probe material has the beneficial effects that 1, the sulfur negative ion fluorescent probe material obtained by the invention has good water solubility, so that the sulfur negative ion fluorescent probe material can emit light in a relatively wide near-infrared region; and 2, the obtained sulfurnegative ion fluorescent probe material is successfully applied to detection of sulfide anions in living cells and zebra fish larvae, an obvious fluorescence recognition phenomenon can be observed, and the sulfur anion fluorescent probe material has the characteristics of high selectivity, high sensitivity and quick response.

Description

technical field [0001] The invention belongs to the field of new materials, and in particular relates to a sulfur anion fluorescent probe material and its preparation method and application. Background technique [0002] Sulfide anion is a common by-product in biological systems, which is produced by the reduction of sulfate by anaerobic bacterial microorganisms and the formation of sulfur-containing amino acids in meat proteins. Sulfide ions are widely used in industrial processes, where their roles include conversion to sulfur and sulfuric acid, preparation of dyes and cosmetics, production of wood pulp, etc. However, sulfide anion is highly toxic and is considered to be one of the common anions that are toxic even at low concentrations. May cause mucous membrane irritation, coma and respiratory paralysis at high concentrations in water. Therefore, it is necessary to detect sulfur anions in aqueous media and biological systems by effective means. [0003] Traditional me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D277/82C09K11/06G01N21/64
CPCC07D277/82C09K11/06G01N21/6428C09K2211/1037C09K2211/1007G01N2021/6443
Inventor 黄薛龙曾炜曹智雄蓝宁
Owner GANNAN MEDICAL UNIV