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Radiotherapy sensitization material based on porous iron-based MOF structure and preparation method and application thereof

A porous iron and iron-based technology, applied in the field of nano-biomedicine, can solve the problems of poor biocompatibility, limited application, biological damage, etc., and achieve the effects of good stability, simple preparation process, and high specific surface area

Inactive Publication Date: 2021-07-27
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, metal nanomaterials with a high atomic number have a strong interaction with high-energy rays, resulting in the generation of scattered photons, photoelectrons, and Auger electrons, which in turn generate ROS and cause biological damage.
However, its poor biocompatibility and single function greatly limit its application.

Method used

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  • Radiotherapy sensitization material based on porous iron-based MOF structure and preparation method and application thereof
  • Radiotherapy sensitization material based on porous iron-based MOF structure and preparation method and application thereof
  • Radiotherapy sensitization material based on porous iron-based MOF structure and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] MIL-101(Fe)-NH 2 Preparation of nanoparticles:

[0049] 0.675g FeCl 3 ·6H 2 O (0.0025mol) and 0.226g 2-aminoterephthalic acid (0.00125mol) were successively loaded into the reaction kettle (lined with polytetrafluoroethylene), and 15mL N,N-dimethylformamide (DMF) was quickly added to In the above-mentioned reaction kettle, seal it after stirring evenly, and react at 110° C. for 24 hours. After the reaction, the product was collected by centrifugation, and the product was washed three times with ethanol and deionized water respectively, and then the washed product was placed in an oven at 40°C for 10 h to obtain the prepared MIL-101(Fe)-NH 2 . MIL-101(Fe)-NH 2 The particle size of the nanoparticles is 80-300nm.

Embodiment 2

[0051] (1) MIL-101(Fe)-NH 2 Preparation of nanoparticles:

[0052] 1.01g Fe(NO 3 )·9H 2 O and 0.226g 2-aminoterephthalic acid are successively loaded into the reaction kettle (polytetrafluoroethylene lining), and 20, 25, and 30mL N,N-dimethylformamide (DMF) are quickly added to the above reaction kettle respectively. , stir evenly and then seal it, and react at 110°C for 24h. After the reaction, the product was collected by centrifugation, and the product was washed three times with ethanol and deionized water respectively, and then the washed product was placed in an oven at 40°C for 10 h to obtain the prepared MIL-101(Fe)-NH 2 . MIL-101(Fe)-NH 2 The size range of the nanoparticles is 80-300nm.

[0053] (2) Radiosensitizing material MIL-101(Fe)-NH based on porous iron-based MOF structure 2 - Preparation of GOx-BSA nanoparticles:

[0054] 0.040g MIL-101(Fe)-NH 2 and 5 mg of GOx were added to 25 mL of water for three times, stirred evenly, added 0.050 g of BSA, stirred...

Embodiment 3

[0057] MIL-101(Fe)-NH 2 - Preparation of BSA:

[0058] Get the synthetic MIL-101(Fe)-NH in embodiment 1 2 Nanoparticles 0.040g, dispersed in 25mL of tertiary water, stirred evenly, added 0.050g BSA, stirred for 24h, centrifuged to collect the product, freeze-dried to obtain MIL-101(Fe)-NH 2 -BSA.

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Abstract

The invention relates to a radiotherapy sensitization material based on a porous iron-based MOF structure and a preparation method and an application thereof. The radiotherapy sensitization material is composed of MIL-101 (Fe)-NH2 nanoparticles of a porous iron-based MOF structure loaded with glucose oxidase, the loading capacity of glucose oxidase in the radiotherapy sensitization material is 19.6 to 42.2 [mu]g / mg; and preferably, the porosity of the MIL-101 (Fe)-NH2 nano particle with the porous iron-based MOF structure is 180 to 2500 m <3> / g.

Description

technical field [0001] The invention relates to a radiotherapy sensitizing material based on a porous iron-based MOF structure and a preparation method and application thereof, belonging to the field of nanobiomedicine. Background technique [0002] Cancer has become the first cause of death in China, and its morbidity and mortality are increasing year by year, and its pathogenesis is complex and changeable. Cancer treatment has become a great challenge in the field of medical research. At present, cancer treatment is still dominated by surgery, chemotherapy and radiotherapy. Among them, radiotherapy, as a non-invasive tumor treatment, is widely used in different types of tumor treatment. However, the effect of low-dose radiation on tumor treatment is very limited, and increasing the radiation dose of radiation will increase its damage to normal organs and tissues and cause complications, making the clinical treatment effect unsatisfactory. Therefore, it is of great resear...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/24A61K47/42A61P35/00
CPCA61K41/0038A61K47/24A61K47/42A61P35/00
Inventor 邵怡然祝迎春黄雍平王云丽王铭
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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