Collagenase inhibitor, preparation method thereof and skin penetrating water containing collagenase inhibitor

A technology of collagenase and inhibitor, which is applied in the field of permeable water, can solve the problems of large molecular weight of hydrolyzed collagen and difficulty reaching the dermis, and achieve the effect of improving skin elasticity, easy raw materials, and mild formula

Pending Publication Date: 2021-07-30
GUANGZHOU KENENG COSMETICS RES CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In view of the existing technology, the molecular weight of hydrolyzed collagen is too large, and it is difficult to penetrate the skin barrier of the human body to reach the dermis; hyaluronic acid cannot essentially slow down the loss of collagen; peptides and retinol have certain irritation and safety risks to the skin etc., the present invention firstly provides a collagenase inhibitor and a preparation method thereof

Method used

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  • Collagenase inhibitor, preparation method thereof and skin penetrating water containing collagenase inhibitor
  • Collagenase inhibitor, preparation method thereof and skin penetrating water containing collagenase inhibitor
  • Collagenase inhibitor, preparation method thereof and skin penetrating water containing collagenase inhibitor

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preparation example Construction

[0043]The preparation method of the collagenase inhibitor of the present invention is not particularly limited, and may be a common method in the art, specifically including the step of mixing the components of the collagenase inhibitor. For example, the wild chrysanthemum extract and the calendula extract are uniformly mixed in a conventional mixing manner.

[0044] Collagenase

[0045] Collagenase belongs to a class of matrix metalloproteinases (Matrix Metalloproteinase, MMPs). Matrix metalloproteinases are a family of endopeptidases whose biological activity depends on zinc ions and has the ability to degrade extracellular matrix (Extra-Cellar Matrix, ECM). The main function of collagenase is to degrade collagen and elastin in the dermis, and its tissue inhibitors (Tissue Inhibitors of Metalloproteinase, TIMPs) specifically inhibit the activity of collagenase by covalently binding to its highly conserved zinc binding site , jointly regulate matrix metabolism and maintai...

Embodiment

[0087] Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention. Those who do not indicate the specific conditions in the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all commercially available conventional products.

[0088] The wild chrysanthemum extract was purchased from: Quzhou Zhanhong Biotechnology Co., Ltd.;

[0089] Calendula extract was purchased from: Quzhou Zhanhong Biotechnology Co., Ltd.

Embodiment 1-5

[0095] Provides wild chrysanthemum flower extract and calendula flower extract as collagenase inhibitors. With calendula extract and wild chrysanthemum extract by mass ratio 3:1 (embodiment 1), 2:1 (embodiment 2), 1:1 (embodiment 3), 1:2 (embodiment 4), After mixing 1:3 (Example 5), the collagenase inhibitor was obtained.

[0096] The collagenase inhibitors of Examples 1-5 were respectively dissolved in 5 groups of deionized water corresponding to the volumes of Comparative Examples 1-5. Examples 1-5 can obtain 5 groups of test solutions corresponding to the concentrations of Comparative Examples 1-5. Wherein, among the collagenase inhibitors, the content (mass %) of the Calendula officinalis extract and the wild chrysanthemum extract are shown in Table 1 below, and the logarithmic mass concentration of the collagenase inhibitor is shown in Table 3 below.

[0097] Table 1

[0098]

[0099] Inhibition of Collagenase Activity Test

[0100] Folin's phenol reagent can be ...

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Abstract

The invention relates to a collagenase inhibitor, a preparation method of the collagenase inhibitor and skin penetrating water containing the collagenase inhibitor. The collagenase inhibitor comprises a wild chrysanthemum flower extract and a calendula extract, and the addition amount of the wild chrysanthemum flower extract is 26.2 to 73.8 percent based on the total mass of the collagenase inhibitor, and the addition amount of the calendula extract is 26.2 to 73.8 percent based on the total mass of the collagenase inhibitor. The collagenase inhibitor of the present invention has an excellent inhibitory effect on the activity of collagenase, and has no side effects on the human body.

Description

technical field [0001] The invention relates to a collagenase inhibitor, a preparation method thereof and a toner containing the collagenase inhibitor, belonging to the field of cosmetics. Background technique [0002] Collagen is mainly produced by fibroblasts in the dermis and is the main component of the dermis. It can maintain the structure of the skin and give the skin toughness and elasticity. The content and distribution of collagen determine the youthfulness of the skin. However, the abnormal reduction of collagen content will cause the thinning of the dermis, loose skin, loss of elasticity, and wrinkles, which will affect people's quality of life. With the deepening of research on collagen, researchers have found that collagenase plays an important role in the homeostasis of skin collagen, and its overexpression and abnormal activation are one of the main causes of skin aging. Therefore, inhibiting the activity of collagenase can block the degradation of skin coll...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/9711A61K8/99A61K8/49A61K8/37A61K8/34A61K8/63A61Q19/08A61Q19/00A61Q19/02
CPCA61K8/9789A61K8/9711A61K8/99A61K8/4946A61K8/375A61K8/345A61K8/63A61Q19/08A61Q19/00A61Q19/02A61K2800/782A61K2800/5922A61K2800/592
Inventor 谢佩佩杨登亮李传茂张楚标曾伟丹张伟杰
Owner GUANGZHOU KENENG COSMETICS RES CO LTD
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