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Yak hide glue/PMVE-MA composite material and preparation method and application thereof

A composite material and yak leather technology, which is applied in the field of yak leather glue/PMVE-MA composite material and its preparation, can solve the problems of resource waste, environmental pollution, and ineffective utilization, and achieve excellent swelling degree and mechanical properties, low The effect of hemolysis rate

Active Publication Date: 2021-08-03
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Yak hide is the waste of meat processing, only a few of them are used to make leather products, most of the yak hide is usually discarded, and the high content of protein in it has not been effectively utilized, resulting in serious waste of resources and environmental pollution. If it can be applied to the field of tissue engineering, it will not only reduce the pollution to the environment, but also make full use of the nutrients in it.

Method used

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  • Yak hide glue/PMVE-MA composite material and preparation method and application thereof
  • Yak hide glue/PMVE-MA composite material and preparation method and application thereof
  • Yak hide glue/PMVE-MA composite material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1, Preparation of Yak Bulp / PMVE-MA Composite Bracket of the Invention

[0040] The formation of yak skin solution (8% w / v) and PMVE-MA solution (1.33% w / v) in 0.5 mol / L acetic acid solution, mixed with 1: 1 ratio (yak leather: PMVE- MA mass ratio 6: 1), magnetic force was stirred at 41 ° C for 3.85 h, and the mixed mixed solution after stirring was poured into a suitable mold, and the freeze-dried, freeze-dried material sample was carried out under -80 ° C for 24 h. 10% HMDI (prepared in isopropyl alcohol) was soaked in a solution for 2 hours, washed twice with isopropyl alcohol, and was naturally widened to be used, and then clean it with pure water three times.

Embodiment 2

[0041] Example 2, Preparation of Yak Bulp / PMVE-MA Composite Bracket of the Invention

[0042]The formulation of yak skin (8% w / v) and PMVE-MA solution (1% w / v) were dissolved with 0.5 mol / L acetic acid solution, and the two solutions were mixed in 1: 1 ratio (yak leather: PMVE- MA mass ratio 8: 1), magnetic force was stirred at 55 ° C for 4 h, and the mixed mixed solution after stirring was poured into a suitable mold, and after crystallizing at -50 ° C for 24 h, crystall dry, freeze-dried material sample in 10 % HMDI (prepared in isopropyl alcohol) was soaked for 3 h after 3 hours, washed twice with isopropyl alcohol, and was naturally widened, and then washed three times with pure water.

Embodiment 3

[0043] Example 3, Preparation of Yak Bulp / PMVE-MA Composite Bracket of the Invention

[0044] The formation of yak skin (8% w / v) and PMVE-MA solution (2% w / v), two solutions were mixed with 0.5 mol / L acetic acid solution, and the two solutions were mixed in 1: 1 ratio (yak leather: PMVE- MA mass ratio 4: 1), magnetic force was stirred at 37 ° C for 1 h, and the mixed solution after stirring was poured into a suitable mold, and after crystallizing at -100 ° C for 24 h, crystall dry, freeze-dried material sample in 10 % HMDI (prepared in isopropyl alcohol) After soaking for 1 h after 1 h, it was cleaned with isopropyl alcohol, and was naturally widened to be used in alcohol, and then washed three times with pure water.

[0045] The beneficial effects of the composite materials of the present invention are demonstrated by experimental examples.

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PUM

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Abstract

The invention provides a yak hide glue / PMVE-MA composite material. The yak hide glue / PMVE-MA composite material is formed by compounding yak hide glue and PMVE-MA according to the mass ratio of (4-8): 1. The yak hide glue / PMVE-MA composite material disclosed by the invention is excellent in swelling degree and mechanical property, the degradation rate can meet the time requirement of implanting a stent material into a body, the microstructure meets the conditions of cell adhesion growth, and the yak hide glue / PMVE-MA composite material has low hemolysis rate and has excellent potential as a tissue engineering stent material.

Description

Technical field [0001] The present invention belongs to the field of composite materials, and specific relates to a yak skin / PMVE-MA composite material and a preparation method thereof. Background technique [0002] In recent years, the composite bracket material has become a research hotspot in the field of medical organization engineering. It has the characteristics of degradability, non-toxicity, good biocompatibility, and good biocompatibility compared to traditional metal and polymer materials. Main raw materials for sexual tissue engineering scaffold materials. Animal gelatin is a natural biomaterial, which has been widely used in tissue engineering. Methylvinyl ether / maleic anhydride copolymer (PMVE-MA) is an FDA-approved acid-amosited acid-amosited polymer, which is biodegradable and low toxicity, which has been applied in research in wound healing. It is used to encapsulate capsule drugs to enhance biological adhesion. Therefore, the gelatin and PMVE-MA are combined ...

Claims

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Application Information

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IPC IPC(8): C08L89/00C08L35/08C08J7/12A61L27/26A61L27/50
CPCC08J7/12A61L27/26A61L27/50C08J2389/00C08J2435/08C08L89/00C08L35/08
Inventor 杨红霞张玉霞杜玉枝肖远灿李岑张明毕宏涛魏立新
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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