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Filling head device for acetylcysteine solution for suction

A technology of acetylcysteine ​​and filling head, which is applied in the field of filling head device for acetylcysteine ​​solution for inhalation, which can solve the problem of increasing the work intensity and difficulty of subsequent light inspection, increasing drug safety risks and production Cost, the needle is easy to touch the inner wall of the bottle mouth, etc., and it is easy to promote and implement, simple in structure, and reduces production costs.

Active Publication Date: 2021-08-06
山西国润制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is because ampoules (91) are usually used for filling, and the needle is easy to touch the inner wall of the bottle mouth during filling, and the liquid drops at the liquid outlet of the needle are easy to stick to the bottle mouth, resulting in The liquid medicine is subjected to high temperature carbonization
The acetylcysteine ​​solution for inhalation produced according to the existing filling process will produce a large number of products containing carbonized black spots, the reject rate is as high as 12%, and the yield rate is lower than the conventional yield rate, which also increases the follow-up light inspection. Work intensity and difficulty, most importantly increased drug safety risks and production costs

Method used

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  • Filling head device for acetylcysteine solution for suction
  • Filling head device for acetylcysteine solution for suction
  • Filling head device for acetylcysteine solution for suction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] See figure 1 , figure 2 with image 3 , a filling head device for acetylcysteine ​​solution for inhalation, comprising a filling needle 10 and a plurality of barriers 20 . The barrier 20 is fixed on the outer wall of the filling needle 10 , and the barrier 20 extends along the axial direction of the filling needle 10 to a position close to the liquid outlet of the filling needle 10 . A plurality of barriers 20 are sequentially arranged at intervals along the circumferential direction of the filling needle 10 . In this embodiment, the filling needle 10 is arranged on the filling equipment, and the filling equipment can drive the filling needle 10 to move up and down to fill the ampoule bottle 91 . The production process of the acetylcysteine ​​solution for inhalation is as follows: (1) Dissolving and dosing according to the process requirements. (2) Insert the filling needle 10 into the ampoule bottle 91 at an insertion height of 4-6mm from the liquid outlet to the ...

Embodiment 2

[0081] Such as Figure 5 As shown, this embodiment is based on the first embodiment, and further defines the filling needle 10 , including: a syringe 11 and a core tube 12 . The core tube 12 is fixed in the syringe 11 , and the lower end of the core tube 12 extends below the lower end of the syringe 11 . The barrier 20 is arranged on the outer wall of the syringe 11 . In this embodiment, the filling needle 10 has a double-layer structure, and the outer syringe 11 can further avoid contact between the core tube 12 and the inner wall of the ampoule bottle 91, thus further increasing the distance between the core tube 12 and the inner wall of the ampoule bottle 91. distance, so that the bottle mouth is relatively clean, and further prevents the medicinal liquid from the liquid outlet of the core tube 12 from sticking to the bottle mouth, and avoids carbonization black spots at the bottle mouth during the subsequent fusing and sealing process.

[0082] Wherein, the liquid medici...

Embodiment 3

[0086] Such as Figure 7 As shown, this embodiment further defines a filling head device for inhaling acetylcysteine ​​solution on the basis of Embodiment 1, including: a fixed frame 40, a lifting arm 50, a filling mounting frame 60, a telescopic arm 70 and residual fluid disposal assembly 80 . The lifting arm 50 is vertically arranged, the fixed end of the lifting arm 50 is fixedly connected with the top of the fixed frame 40 , and the telescopic end of the lifting arm 50 is fixedly connected with the filling installation frame 60 . The filling installation frame 60 is fixedly connected with the filling needle 10 . The filling installation frame 60 is used for installing the filling needle 10 . The telescopic arm 70 is arranged horizontally. The telescopic arm 70 is located below the filling installation frame 60. The fixed end of the telescopic arm 70 is connected to the side wall of the fixed frame 40. The telescopic end of the telescopic arm 70 is fixedly connected to th...

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PUM

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Abstract

The invention discloses a filling head device for an acetylcysteine solution for suction. The filling head device comprises a filling needle and a plurality of partition pieces. The partition pieces are fixedly arranged on the outer wall of the filling needle and extend to the position close to a liquid outlet of the filling needle in the axial direction of the filling needle; and the multiple partition pieces are sequentially arranged in the circumferential direction of the filling needle at intervals. The partition pieces are arranged on the outer wall of the filling needle, the filling needle and the inner wall of an ampoule bottle can be partitioned, the filling needle is prevented from making direct contact with the inner wall of a bottle opening of the ampoule bottle, liquid medicine at a liquid outlet of a needle head of the filling needle can be prevented from being attached to the bottle opening, and therefore carbonized black spots can be prevented from being generated at the bottle opening in the follow-up heat sealing process, the rejection rate is reduced, the yield is improved, the working efficiency of subsequent links is improved, the liquid medicine in the bottle is prevented from being polluted, the safety of the acetylcysteine solution medicine is improved, and the production cost is reduced. The filling needle is simple in structure and easy to popularize and implement.

Description

technical field [0001] The invention belongs to the technical field of medicine filling, in particular to a filling head device for inhaling acetylcysteine ​​solution. Background technique [0002] Acetylcysteine ​​(Acetylcysteine), as a mucolytic agent, has been widely used as an expectorant in the clinical treatment of various respiratory diseases since the 1960s. Its molecular structural formula is as follows: [0003] [0004] Its mechanism of action is that acetylcysteine ​​contains a sulfhydryl group (-SH), which can break the disulfide bond (-S-S) in the polypeptide chain and reduce the viscosity of sputum, so that it is easy to excrete the respiratory tract and stimulate the airway epithelial villi. Exercise promotes mucus clearance. In recent years, it has been found that it has a protective effect on liver cells and is used to treat liver cell damage caused by various reasons. Among them, acetylcysteine ​​has been approved by the US FDA for the treatment of ac...

Claims

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Application Information

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IPC IPC(8): B65B39/00B65B3/00B67C3/26
CPCB65B39/00B65B3/003B67C3/2608
Inventor 杨育平
Owner 山西国润制药有限公司