Preparation method and application of anti-Hp coptis traditional Chinese medicine preparation

A traditional Chinese medicine preparation, Coptis chinensis technology, applied in antibacterial drugs, antineoplastic drugs, medical formulas, etc., can solve the problems of low Hp eradication rate, antibiotic resistance, etc., achieve good effect, eliminate side effects, and heal the stomach and intestines effects of disease

Inactive Publication Date: 2021-08-13
重庆伊士腾生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, anti-H. pylori is mainly treated with triple therapy, but with the use of antibiotics, resistance to antibiotics has developed, and the eradication rate of H.

Method used

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  • Preparation method and application of anti-Hp coptis traditional Chinese medicine preparation
  • Preparation method and application of anti-Hp coptis traditional Chinese medicine preparation
  • Preparation method and application of anti-Hp coptis traditional Chinese medicine preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Preparation of Coptis Rhizoma Extract Ⅰ:

[0033] Weigh 95Kg of Coptidis Rhizoma Tablets, extract 3 times with 5 times the amount of 40% ethanol under reflux, combine the extracts, filter and recover the solvent, concentrate into a thick paste, and obtain Coptidis Rhizoma Extract I, weighing 30Kg; carry out HPLC content analysis on Coptidis Rhizoma Extract I , berberine 17.5%, palmatine 5.1%, coptisine 5.6%, epiberberine 2.5%; HPLC spectrum see attached figure 1 .

[0034] Preparation of Coptis Rhizoma Extract II:

[0035] Weigh 95Kg Coptis chinensis slices, soak for 48 hours with 30 times the amount of 0.1% (V / V) sulfuric acid aqueous solution, and then extract by percolation; the extract is neutralized with lime aqueous solution to pH=1 of the solution, filtered, and the filtrate is concentrated under reduced pressure to Dried to obtain Coptidis extract II, weighing 25.5Kg; HPLC content analysis was carried out on Coptidis extract II, berberine 22.2%, palmatine 6.5%...

Embodiment 2

[0042] Preparation of Coptis Rhizoma Extract Ⅰ:

[0043] Weigh 60Kg of Coptidis Rhizoma Tablets, extract 3 times with 5 times the amount of 70% ethanol under reflux, combine the extracts, filter and recover the solvent, concentrate into a thick paste, and obtain Coptidis Rhizoma Extract I, weighing 18Kg; carry out HPLC content analysis on Coptidis Rhizoma Extract I , berberine 17.8%, palmatine 5.3%, coptisine 5.5%, epiberberine 2.4%.

[0044] Preparation of Coptis Rhizoma Extract II:

[0045] Weigh 60Kg Coptis chinensis slices, soak for 1 hour with 30 times the amount of 2% (V / V) sulfuric acid aqueous solution, and then extract by percolation; the extract is neutralized with lime aqueous solution to pH=2 of the solution, filtered, and the filtrate is concentrated under reduced pressure to Dry to obtain Coptis Rhizoma Extract II, weighing 19Kg; carry out HPLC content analysis to Coptidis Rhizoma Extract II, berberine 18.2%, palmatine 5.3%, coptisine 5.7%, epiberberine 2.5%.

...

Embodiment 3

[0052] Preparation of Coptis Rhizoma Extract Ⅰ:

[0053] Weigh 85Kg Coptis chinensis tablets, extract 3 times with 5 times the amount of 60% ethanol under reflux, combine the extracts, filter and recover the solvent, concentrate into a thick paste, and obtain Coptis chinensis extract I, weighing 25.5Kg; Analysis, berberine 17.6%, palmatine 5.5%, coptisine 5.7%, epiberberine 2.6%.

[0054] Preparation of Coptis Rhizoma Extract II:

[0055] Weigh 85Kg Coptis chinensis slices, soak for 12 hours with 30 times the amount of 1% (V / V) sulfuric acid aqueous solution, and then extract by percolation; the extract is neutralized with lime aqueous solution to pH=4 of the solution, filtered, and the filtrate is concentrated under reduced pressure to Dry to obtain Coptis Rhizoma Extract II, weighing 26.5Kg; carry out HPLC content analysis to Coptidis Rhizoma Extract II, berberine 18.4%, palmatine 5.4%, coptisine 5.5%, epiberberine 2.6%.

[0056] Preparation of Coptis Rhizoma Extract III: ...

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PUM

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Abstract

Aiming at the characteristics of poor taste and safety of an existing Zuojin pill, strong drug resistance of the triple therapy and the like, the invention provides an anti-Hp coptis traditional Chinese medicine preparation which comprises 60-95 parts by weight of coptis extract and 5-40 parts by weight of fructus evodiae extract, and the coptis uextract is one of a coptis extract I, a coptis extract II and a coptis extract III. The invention further provides a preparation method and application of the anti-Hp coptis traditional Chinese medicine preparation. The anti-Hp coptis traditional Chinese medicine preparation effectively eliminates the side effects of the product and improves the safety of the medicine.

Description

technical field [0001] The invention is applied in the technical field of traditional Chinese medicine preparations, and in particular relates to a preparation method and application of an anti-Hp coptis traditional Chinese medicine preparation. Background technique [0002] Coptis chinensis was first recorded in "Shen Nong's Materia Medica" and listed as top grade. Coptis chinensis is bitter in taste, cold in nature, and has the functions of purging fire, detoxifying, clearing away heat, and drying dampness. For dysphoria, confusion, upset and insomnia, hot and humid fullness, vomiting, abdominal pain and diarrhea, conjunctival congestion and swelling, sore tongue, eczema, burns, vomiting blood, epistaxis, etc. A large number of research results show that Coptidis Rhizome has a strong anti-Helicobacter pylori (HP) effect (Xu Yi et al. Study on the antibacterial effect of single and compound Chinese herbal medicines on Helicobacter pylori, Chinese Journal of Integrative Tra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/754A61K45/06A61P31/04A61P35/00A61P1/04A61K36/718
CPCA61K36/718A61K36/754A61K45/06A61P31/04A61P35/00A61P1/04A61K2236/333A61K2236/39A61K2236/53A61K2236/51
Inventor 李学刚叶小利
Owner 重庆伊士腾生物科技有限公司
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