Preparation method and application of anti-Hp coptis traditional Chinese medicine preparation
A traditional Chinese medicine preparation, Coptis chinensis technology, applied in antibacterial drugs, antineoplastic drugs, medical formulas, etc., can solve the problems of low Hp eradication rate, antibiotic resistance, etc., achieve good effect, eliminate side effects, and heal the stomach and intestines effects of disease
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Embodiment 1
[0032] Preparation of Coptis Rhizoma Extract Ⅰ:
[0033] Weigh 95Kg of Coptidis Rhizoma Tablets, extract 3 times with 5 times the amount of 40% ethanol under reflux, combine the extracts, filter and recover the solvent, concentrate into a thick paste, and obtain Coptidis Rhizoma Extract I, weighing 30Kg; carry out HPLC content analysis on Coptidis Rhizoma Extract I , berberine 17.5%, palmatine 5.1%, coptisine 5.6%, epiberberine 2.5%; HPLC spectrum see attached figure 1 .
[0034] Preparation of Coptis Rhizoma Extract II:
[0035] Weigh 95Kg Coptis chinensis slices, soak for 48 hours with 30 times the amount of 0.1% (V / V) sulfuric acid aqueous solution, and then extract by percolation; the extract is neutralized with lime aqueous solution to pH=1 of the solution, filtered, and the filtrate is concentrated under reduced pressure to Dried to obtain Coptidis extract II, weighing 25.5Kg; HPLC content analysis was carried out on Coptidis extract II, berberine 22.2%, palmatine 6.5%...
Embodiment 2
[0042] Preparation of Coptis Rhizoma Extract Ⅰ:
[0043] Weigh 60Kg of Coptidis Rhizoma Tablets, extract 3 times with 5 times the amount of 70% ethanol under reflux, combine the extracts, filter and recover the solvent, concentrate into a thick paste, and obtain Coptidis Rhizoma Extract I, weighing 18Kg; carry out HPLC content analysis on Coptidis Rhizoma Extract I , berberine 17.8%, palmatine 5.3%, coptisine 5.5%, epiberberine 2.4%.
[0044] Preparation of Coptis Rhizoma Extract II:
[0045] Weigh 60Kg Coptis chinensis slices, soak for 1 hour with 30 times the amount of 2% (V / V) sulfuric acid aqueous solution, and then extract by percolation; the extract is neutralized with lime aqueous solution to pH=2 of the solution, filtered, and the filtrate is concentrated under reduced pressure to Dry to obtain Coptis Rhizoma Extract II, weighing 19Kg; carry out HPLC content analysis to Coptidis Rhizoma Extract II, berberine 18.2%, palmatine 5.3%, coptisine 5.7%, epiberberine 2.5%.
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Embodiment 3
[0052] Preparation of Coptis Rhizoma Extract Ⅰ:
[0053] Weigh 85Kg Coptis chinensis tablets, extract 3 times with 5 times the amount of 60% ethanol under reflux, combine the extracts, filter and recover the solvent, concentrate into a thick paste, and obtain Coptis chinensis extract I, weighing 25.5Kg; Analysis, berberine 17.6%, palmatine 5.5%, coptisine 5.7%, epiberberine 2.6%.
[0054] Preparation of Coptis Rhizoma Extract II:
[0055] Weigh 85Kg Coptis chinensis slices, soak for 12 hours with 30 times the amount of 1% (V / V) sulfuric acid aqueous solution, and then extract by percolation; the extract is neutralized with lime aqueous solution to pH=4 of the solution, filtered, and the filtrate is concentrated under reduced pressure to Dry to obtain Coptis Rhizoma Extract II, weighing 26.5Kg; carry out HPLC content analysis to Coptidis Rhizoma Extract II, berberine 18.4%, palmatine 5.4%, coptisine 5.5%, epiberberine 2.6%.
[0056] Preparation of Coptis Rhizoma Extract III: ...
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