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Electrochemical luminescence cleaning solution

A cleaning solution, electrochemical technology, applied in chemiluminescence/bioluminescence, analysis by chemical reaction of materials, scientific instruments, etc., can solve the problems of difficult dispersion, easy volatility, high toxicity, etc. Low toxicity and enhanced luminous intensity

Active Publication Date: 2021-08-24
济南迪曼生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the tripropylamine cleaning solution contains a relatively high concentration of tripropylamine. Tripropylamine has the disadvantages of high toxicity, volatile, insoluble in water and difficult to disperse. Therefore, it is necessary to develop a new environmentally friendly and efficient co-reaction reagent composition.

Method used

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  • Electrochemical luminescence cleaning solution
  • Electrochemical luminescence cleaning solution
  • Electrochemical luminescence cleaning solution

Examples

Experimental program
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Effect test

Embodiment 1

[0033] An electrochemiluminescent cleaning solution, comprising the following components:

[0034] Diethylaminoethanol 5g / L, potassium dihydrogen phosphate 10g / L, phosphoric acid 1g / L, fatty alcohol polyoxyethylene ether 0.1g / L, cetyltrimethylammonium bromide 0.1g / L, 5-chloro -2-Methyl-4-isothiazolin-3-one 0.01g / L;

[0035] The mass percentage of the phosphoric acid is 85%, the degree of polymerization of the fatty alcohol polyoxyethylene ether is 9, and the pH value of the cleaning solution is 6.5.

Embodiment 2

[0037] An electrochemiluminescent cleaning solution, comprising the following components:

[0038] Diethylaminoethanol 50g / L, potassium dihydrogen phosphate 50g / L, phosphoric acid 5g / L, fatty alcohol polyoxyethylene ether 5g / L, cetyltrimethylammonium bromide 5g / L, 5-chloro-2 -Methyl-4-isothiazolin-3-one 0.1g / L;

[0039] The mass percentage of the phosphoric acid is 85%, the degree of polymerization of the fatty alcohol polyoxyethylene ether is 9, and the pH value of the cleaning solution is 7.5.

Embodiment 3

[0041] An electrochemiluminescent cleaning solution, comprising the following components:

[0042] Diethylaminoethanol 10g / L, potassium dihydrogen phosphate 20g / L, phosphoric acid 2g / L, fatty alcohol polyoxyethylene ether 0.5g / L, cetyltrimethylammonium bromide 0.5g / L, 5-chloro -2-Methyl-4-isothiazolin-3-one 0.02g / L;

[0043] The mass percentage of the phosphoric acid is 85%, the degree of polymerization of the fatty alcohol polyoxyethylene ether is 9, and the pH value of the cleaning solution is 6.7.

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Abstract

The invention is applicable to the field of medical instrument in-vitro diagnostic reagents, and provides an electrochemical luminescence cleaning solution which comprises the following components: diethylaminoethanol, monopotassium phosphate, phosphoric acid, fatty alcohol-polyoxyethylene ether, hexadecyl trimethyl ammonium bromide and 5-chloro-2-methyl-4-isothiazolin-3-one. According to the embodiment of the invention, the diethylaminoethanol is used as a co-reaction reagent, compared with tripropylamine, the diethylaminoethanol is high in sensitivity and good in catalytic effect, the reaction can be excited by using a smaller amount of diethylaminoethanol, and the diethylaminoethanol is more environment-friendly, small in toxicity, small in volatility and good in water solubility; and the problems that an existing tripropylamine cleaning solution used as a co-reaction reagent is high in toxicity, easy to volatilize, insoluble in water and difficult to disperse are solved.

Description

technical field [0001] The invention belongs to the field of in vitro diagnostic reagents for medical devices, in particular to an electrochemiluminescence cleaning solution. Background technique [0002] Electrochemiluminescence immunoassay (ECLI). ECLI is a new generation of labeled immunoassay technology following radioimmunoassay, enzyme immunoassay, fluorescence immunoassay, and chemiluminescence immunoassay. ECLI is the product of the combination of electrochemiluminescence (ECL) and immunoassay, and it is a specific chemiluminescent reaction induced by electrochemistry on the electrode surface. As the most advanced marker immunoassay technology at present, it has the advantages of accurate detection, less specimen consumption, high stability, and convenient operation, and is widely used in clinical testing. [0003] Roche Cobas series electrochemiluminescence immunoassay analyzers have high detection sensitivity, wide linear range, and good repeatability of result...

Claims

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Application Information

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IPC IPC(8): G01N21/76G01N33/53G01N33/58
CPCG01N21/76G01N33/5306G01N33/58
Inventor 丁少祥陈杰
Owner 济南迪曼生物科技有限公司
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