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Synergistic preservative compositions, process for preparing the same and method of use thereof

A technology of preservatives and compositions, applied in the field of synergistic preservative compositions, which can solve problems such as inability to protect end-user products

Active Publication Date: 2021-08-24
ISP INVESTMENTS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In addition, the permitted use levels of conventional, traditional and progressive preservatives do not protect end-user products under current regulatory guidelines

Method used

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  • Synergistic preservative compositions, process for preparing the same and method of use thereof
  • Synergistic preservative compositions, process for preparing the same and method of use thereof
  • Synergistic preservative compositions, process for preparing the same and method of use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Example 1: Synergistic effect / efficacy of preservative formulations containing PC (propylene carbonate), CHA (octanoylhydroxamic acid) and IPMP (isopropylmethylphenol).

[0079] Tables 1 to 3 below provide the different synergistic compositions prepared for the purposes of the present invention:

[0080] Table 1: Synergistic composition 1

[0081]

[0082] Table 2: Synergistic composition 2

[0083]

[0084] Table 3: Synergistic composition 3

[0085]

Embodiment 2

[0086] Example 2: Synergistic activity:

[0087] The synergistic activity of PC and (CHA+IPMP) compounds was performed on selected microbial strains. The synergistic effect of these compositions was demonstrated by testing a wide range of concentrations and ratios of the compounds as follows.

[0088] Tryptic Soy Broth (TSB) medium was used for bacterial evaluation and Yeast Malt Broth (YMB) was used for fungal evaluation. An IPMP solution was prepared by mixing 0.25% IPMP with 20% DMSO and water (qs. to 100%). A CHA solution was prepared by mixing 0.5% CHA with 20% DMSO and water (qs. to 100%). Compounds were then added to medium (50 [mu]L) and serially diluted. Add the same amount of PC (eg, 50 μL of a 6.25% solution) to all wells. Add 100 μl of the test bacterial or fungal suspension to a final concentration of about 10 in the double concentrated medium 6 CFU / ml. The inoculated medium was then incubated at 32°C for 2-5 days for bacteria, or 3-7 days at 28°C for fungi....

Embodiment 3

[0102] Embodiment 3: efficacy data

[0103]Efficacy data for synergistic preservative compositions were generated in different products following a 28-day double inoculation challenge trial. Briefly, with Gram-positive bacteria (Staphylococcus aureus 6538), Gram-negative bacteria complex (bacteria complex) (Escherichia coli 8739, Pseudomonas aeruginosa 9027 and Burkholderia cepacia 25416 ) or mold complexes (mold complexes) (C. albicans 10231 and Aspergillus brasiliensis 16404) were inoculated with samples containing synergistic preservative compositions or controls (no preservatives). Bacteria were inoculated on days 0 and 21 to a final concentration of approximately 10^ 6-7 cfu / ml, inoculate the fungal complex on days 0 and 21 to a final concentration of approximately 10^ 5-6 spores / ml. Inoculated samples were plated on days 2, 7, 14, 21 and 28. Recovery media was Lee's agar for bacteria and potato dextrose agar for fungi.

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PUM

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Abstract

Described herein is a synergistic preservative composition used for providing broad spectrum antimicrobial activity comprising: (i) about 0.1 wt. % to about 99.9 wt. % of propylene carbonate; (ii) about 0.1 wt. % to about 99.9 wt. % of one or more organic compounds selected from the group consisting of propanediol, capryl hydroxamic acid, and isopropyl methyl phenol; and (iii) about 0.1 wt. % to 99.0 wt. % of phenoxy ethanol, a preservative compound, and wherein, the composition provides synergy having Synergy Index (SI) value of the total composition from about 0.05 to about 1.0. Also described is a process for preparing said synergistic preservative composition and method of using the same.

Description

technical field [0001] The present application relates to a synergistic preservative composition, in particular to a synergistic preservative composition providing broad-spectrum antibacterial activity, the preservative composition comprising propylene carbonate, one or more organic compounds and at least one preservative compound. Background technique [0002] Preservatives or preservative systems are used in a variety of non-limiting industrial applications including personal care, household, coatings, metalworking fluids, paper, wood, plastics, disinfection, cosmetics, toiletry, pharmaceuticals, food, beverages, oral care, paints or water treatment to overcome microbial contamination problems based on mildew, mildew, fungus and bacteria. [0003] In particular, personal care, pharmaceuticals, food, beverages, nutraceutical products, fragrance products, cosmetics, nutraceuticals, cosmetics, therapeutic, skin care and anti-aging products often incorporate ingredients that c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/22A01N31/02A01N43/28
CPCA01N31/02A01N43/28A01N31/14A01N37/28A01N31/08A01N25/30
Inventor 郭梅燕K·温克瓦斯基N·H·海克米R·普雷马钱德兰瞿欣
Owner ISP INVESTMENTS INC
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